Mechanical Ventilation on Hippocampus
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBeijing Sanbo Brain Hospital
About this trial
Ventilator-associated brain injury (VABI) frequently occurs in ICU patients. Although animal studies indicate the hippocampus as a key target of VABI, its relevance in human patients remains uncertain. In this study, the investigators aim to monitor hippocampal EEG activity during the weaning process of patients off mechanical ventilation, and also exploring the coupling between breathing patterns and hippocampal activity.
Eligibility criteria
Qualifiers
Age: ≥ 18 years
ASA: I - II
w/ electrode inside hippocampus (≥ 1 contacts)
Singed consent form
Disqualifiers
Seizure occurrence ≤ 36 hours before op.
Structural brain damage
History of using: opioids, enzyme-inducing medications, sleep aids, or excessive alcohol consumption
History of mechanical ventilation (>24h)
Trial design
Treatments tested in this trial
- Mechanical ventilation
Treatment groups
No treatment groups listed
Locations
1Beijing Sanbo Brain Hospital, Capital Medical University100090, BeijingBeijing Municipality, China
Sponsors and collaborators
Beijing Sanbo Brain Hospital
Lead sponsor
Source ClinicalTrials.gov