[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503231":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":43,"centralContacts":48,"locations":57,"responsibleParty":75,"collaborators":30,"id":77,"slug":30,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":30,"eligibilityCriteria":81,"healthyVolunteers":78,"sex":82,"minAge":83,"maxAge":30,"enrollmentInfo":84,"targetDuration":30,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":60,"whyStopped":30,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Spaulding Rehabilitation Hospital","OTHER",[8,14,20,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Active rTMS","ACTIVE_COMPARATOR","The participant will receive a session of low frequency rTMS to the contralesional primary motor cortex. Low frequency rTMS stimulation will be applied according to the following parameter: intensity of 80% MT (intensity could be adjusted if not comfortable to the subject), frequency of 1 Hz, 1200 pulses as a single, continuous train lasting 20 minutes.",[13],"Device: Active rTMS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham rTMS","SHAM_COMPARATOR","The investigators will place the coil in the same location, usually used for the active stimulation with the same stimulation parameters. However, the investigators will replace the active coil with a sham coil to ensure no stimulation is provided.",[19],"Device: Sham rTMS",{"label":21,"type":22,"description":23,"interventionNames":24},"Open Placebo","PLACEBO_COMPARATOR","The open placebo will consist of typical prescription medicine bottle of placebo pills with a label clearly marked \"placebo pills\" \"take 2 pills twice daily.\" The placebo pills are made from Microcrystalline Cellulose.",[25],"Dietary Supplement: Open Placebo",{"label":27,"type":28,"description":29,"interventionNames":30},"No Intervention","NO_INTERVENTION","It consists of treatment-as-usual group.",null,[32,36,39],{"type":33,"name":9,"description":34,"armGroupLabels":35,"otherNames":30},"DEVICE","Subjects will undergo repetitive transcranial magnetic stimulation, each session lasting 20 minutes.",[9],{"type":33,"name":15,"description":37,"armGroupLabels":38,"otherNames":30},"Subjects will undergo sham repetitive transcranial magnetic stimulation, each session lasting 20 minutes.",[15],{"type":40,"name":21,"description":41,"armGroupLabels":42,"otherNames":30},"DIETARY_SUPPLEMENT","The open placebo will consist of an inactive substance pill commonly used in clinical trials and given to the subject in a regular pill dispenser.",[21],[44],{"name":45,"affiliation":46,"role":47},"Felipe Fregni, MD, PhD, MPH","Spaulding Rehabilitation Hospital\u002FHarvard Medical School","PRINCIPAL_INVESTIGATOR",[49,53],{"name":45,"role":50,"phone":51,"phoneExt":30,"email":52},"CONTACT","6179526156","fregni.felipe@mgh.harvard.edu",{"name":54,"role":50,"phone":55,"phoneExt":30,"email":56},"Elly Pichardo, MD","6179526154","epichardo@partners.org",[58],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Spaulding Hospital Cambridge","RECRUITING","Cambridge","Massachusetts","02138","United States",{"type":66,"coordinates":67},"Point",[68,69],-71.10561,42.3751,{"lat":69,"lon":68},[72,74],{"name":54,"role":50,"phone":73,"phoneExt":30,"email":56},"617-952-6158",{"name":45,"role":47,"phone":30,"phoneExt":30,"email":30},{"type":47,"investigatorFullName":45,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Director of Spaulding Neuromodulation Center","100503231",false,"NCT05832567","Mechanisms of Open and Hidden Placebo in Stroke Recovery","Inclusion Criteria:\n\n1. Adults with hemiparesis due to chronic stroke\n2. Stroke duration of 6 months or more\n3. Fugl-Meyer scale upper extremity motor assessment score of \\> 11 and ≤ 56\n4. Pre-stroke disability (defined as a score of \\\u003C 3 on the Modified Rankin Scale)\n5. Age 18 or older\n\nExclusion Criteria:\n\n1. Stroke of anterior cerebral artery territory with prefrontal lesion and stroke-related decreased EEG power in the prefrontal cortex\n2. Unable to understand instructions\n3. TMS contraindications: electronic hardware in close contact to the discharging coil such as cochlear implant, internal pulse generator or medical pump\n4. Concurrent unstable medical conditions\n5. A score of 24 or higher on the Hamilton Depression Rating Scale (HDRS)\n6. Joint or paretic extremity pain likely to interfere with assessments\n7. Pregnancy","ALL","18 Years",{"count":85,"type":86},56,"ESTIMATED","INTERVENTIONAL",[89],"NA","This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.",[92,93],"Stroke","Hemiparesis",[95,96],"stroke","placebo","2025-09-15",{"date":99,"type":100},"2025-09-17","ACTUAL",{"date":102,"type":100},"2023-09-11",{"date":104,"type":86},"2026-06-30",{"name":5,"class":6},1]