[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611577":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":22,"centralContacts":26,"locations":31,"responsibleParty":49,"collaborators":10,"id":52,"slug":10,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":10,"overallStatus":69,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Post-menopausal females using menopausal hormone therapy",null,"Post menopausal females taking a clinically prescribed menopausal hormone therapy (i.e. pill, patch, etc.)",[13],"Drug: Menopausal Hormone Therapy",{"label":15,"type":10,"description":10,"interventionNames":10},"Post-menopausal females not using menopausal hormone therapy",[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DRUG","Menopausal Hormone Therapy","Taken in accordance with standard clinical practice, administered for a minimum duration of eight weeks.",[9],[23],{"name":24,"affiliation":5,"role":25},"Joshua Bock, Ph.D.","PRINCIPAL_INVESTIGATOR",[27],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","507-422-0768","bock.joshua@mayo.edu",[32],{"facility":33,"status":10,"city":34,"state":35,"zip":36,"country":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Mayo Clinic in Rochester","Rochester","Minnesota","55905","United States",{"type":39,"coordinates":40},"Point",[41,42],-92.4699,44.02163,{"lat":42,"lon":41},[45,48],{"name":46,"role":28,"phone":47,"phoneExt":10,"email":30},"Joshua Bock, PhD","(507) 422-0768",{"name":46,"role":25,"phone":10,"phoneExt":10,"email":10},{"type":25,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Joshua M. Bock","Principal Investigator","100611577",false,"NCT07242391","Menopausal Hormone Therapy And Left Ventricular Function","Menopausal Hormone Therapy And Neural Control Of Left Ventricular Function","Inclusion Criteria\n\n• \\>45-60\\\u003C years of age\n\nExclusion Criteria\n\n* Male sex\n* Females between STRAW+10 stages -5 and 0\n* PMF in STRAW+10 stage +2\n* PMF using oral hormone therapy\n* Females who entered menopause due to a surgical procedure or in response to pharmacotherapy (e.g., gonadotrophin releasing hormone agonists or chemotherapy)\n* Heart disease such as hypertropic cardiomyopathy, congenital abnormalities, chronic heart failure, valve disease, and a history of myocardial infarction\n* Medications that impact the central nervous system including selective serotonin reuptake inhibitors, anxiolytics, sedatives, anticholinergic agents, dopamine, amphetamines, or wake-promoting agents (e.g., modafinil). Other medications will be evaluated on an individual basis by the PI.\n* Cardiovascular medications is also an exclusion criterion which includes those acting on the renin-angiotensin-aldosterone axis, adrenergic receptor antagonists, diuretics, nitrates, and calcium channel antagonists. Other medications will be evaluated on an individual basis by the PI.\n* Pregnancy\n* COPD\n* Diabetes\n* CKD\n* Raynaud's phenomenon\n* Sleep disorders\n* Shift workers\n* BMI ≥40.0kg\u002Fm2\n* Use of nicotine-containing products within the two years preceding study visits\n* Active cancer treatment","FEMALE","45 Years","60 Years",{"count":62,"type":63},50,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to compare left ventricular stroke volume and heart rate responses to bursts of SNA between PMF using, and not using, MHT.",[67,68],"Menopause","Left Ventricular Dysfunction","NOT_YET_RECRUITING","2026-04-22",{"date":72,"type":73},"2026-04-23","ACTUAL",{"date":75,"type":63},"2026-07",{"date":77,"type":63},"2027-12",{"name":5,"class":6},1]