[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606830":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":46,"collaborators":10,"id":48,"slug":10,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Volunteers",null,"Single group design",[13],"Device: transcranial magnetic stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","transcranial magnetic stimulation","Subjects will receive a series of 60 10s trains that will be presented over the course of the \\~3.5 min session. Each train will consist of 2 s of stimulation with an 8 s ITI. During the 2 s of stimulation, 10, 50 Hz bursts will be repeated at intervals of 200 ms (5 Hz). iTBS will be administered at 100% of the motor threshold (MT).",[9],[21],{"name":22,"affiliation":5,"role":23},"Nicholas Balderston, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","12157463058","nicholas.balderston@pennmedicine.upenn.edu",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Philadelphia","Pennsylvania","19104","United States",{"type":37,"coordinates":38},"Point",[39,40],-75.16362,39.95238,{"lat":40,"lon":39},[43],{"name":44,"role":26,"phone":45,"phoneExt":10,"email":28},"Nicholas l Balderston, PhD","215-746-3058",{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100606830",false,"NCT07180654","Menstrual Cycle TMS Plasticity Pilot","Pilot Study on Menstrual Cycle-Related Hormonal Effects on Motor Cortex Plasticity Assessed by TMS in Healthy Young Adults","Inclusion Criteria:\n\n* Able to give their consent\n* If female, must have menstrual cycles of normal frequency, regularity, and duration.\n\nExclusion Criteria:\n\n* Non-English speaking\n* Any medical condition that increases risk for TMS\n* History of seizure\n* History of epilepsy\n* Increased risk of seizure for any reason",true,"ALL","20 Years","40 Years",{"count":59,"type":60},100,"ESTIMATED","OBSERVATIONAL","Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females.\n\nAim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS response.\n\nAim 3: Examine associations between serum hormone levels and TMS-induced plasticity within and between sexes.",[64],"Cortical Activation",[17,66,67],"cortical excitability","hormones","2026-01-07",{"date":70,"type":71},"2026-01-09","ACTUAL",{"date":73,"type":71},"2025-12-15",{"date":75,"type":60},"2028-10-31",{"name":5,"class":6},1]