[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563966":3},{"organization":4,"outcomesModule":7,"designInfo":35,"detailedDescription":43,"studyPopulation":34,"armGroups":44,"interventions":54,"overallOfficials":63,"centralContacts":67,"locations":75,"responsibleParty":90,"collaborators":93,"id":101,"slug":34,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":107,"sex":108,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":34,"studyType":114,"phases":115,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":77,"whyStopped":34,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"University of Copenhagen","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":34},[9],{"measure":10,"description":11,"timeFrame":12},"Ketone Bodies","To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on circulating ketone body concentrations.","During both individual test days",[14,17,20,23,26,28,31],{"measure":15,"description":16,"timeFrame":12},"Resting metabolic rate","To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on resting metabolic rate.",{"measure":18,"description":19,"timeFrame":12},"Respiratory exchange ratio","To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on respiratory exchange ratio.",{"measure":21,"description":22,"timeFrame":12},"Vasodilator Function","To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on vasodilator function.",{"measure":24,"description":25,"timeFrame":12},"Fatty Acid Composition","To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on fatty acid composition.",{"measure":27,"description":11,"timeFrame":12},"Metabolites",{"measure":29,"description":30,"timeFrame":12},"Hepatokines","To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on circulating hepatokine concentrations.",{"measure":32,"description":33,"timeFrame":12},"Beta cell function","To measure the effect of Medium-Chain Fatty Acid (MCFA) and Long-Chain Fatty Acid (LCFA) on Beta cell function.",null,{"allocation":36,"interventionModel":37,"interventionModelDescription":34,"primaryPurpose":38,"observationalModel":34,"timePerspective":34,"maskingInfo":39},"RANDOMIZED","CROSSOVER","BASIC_SCIENCE",{"masking":40,"maskingDescription":34,"whoMasked":41},"SINGLE",[42],"PARTICIPANT","Male and female MCADD patients and healthy individuals will be included in this study which is a randomized intervention study in a cross over design consisting of two separate test days.\n\nThe study involves two test days of four hours each, during which the participants ingests either medium-chain fatty acids (MCFA) or long-chain fatty acids (LCFA) in the form of triacylglycerol oils. The order of fatty acid oils ingested is determined by randomization.",[45,51],{"label":46,"type":47,"description":34,"interventionNames":48},"Healthy Participants","EXPERIMENTAL",[49,50],"Other: Medium-Chain Fatty Acid (MCFA)","Other: Long-Chain Fatty Acid (LCFA)",{"label":52,"type":47,"description":34,"interventionNames":53},"MCADD Patients",[49,50],[55,59],{"type":6,"name":56,"description":57,"armGroupLabels":58,"otherNames":34},"Medium-Chain Fatty Acid (MCFA)","The participants will consume Medium-Chain Fatty Acid (MCFA) followed by Long-Chain Fatty Acid (LCFA)",[46,52],{"type":6,"name":60,"description":61,"armGroupLabels":62,"otherNames":34},"Long-Chain Fatty Acid (LCFA)","The participants will consume Long-Chain Fatty Acid (LCFA) followed by Medium-Chain Fatty Acid (MCFA).",[46,52],[64],{"name":65,"affiliation":5,"role":66},"Andreas M Fritzen, Associate Professor","PRINCIPAL_INVESTIGATOR",[68,73],{"name":69,"role":70,"phone":71,"phoneExt":34,"email":72},"Kasper S Jørgensen, PhD student","CONTACT","+4523473023","kaspersuhr@sund.ku.dk",{"name":65,"role":70,"phone":34,"phoneExt":34,"email":74},"amfritzen@sund.ku.dk",[76],{"facility":5,"status":77,"city":78,"state":34,"zip":34,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":87},"RECRUITING","Copenhagen","Denmark","DK",{"type":82,"coordinates":83},"Point",[84,85],12.56553,55.67594,{"lat":85,"lon":84},[88],{"name":65,"role":70,"phone":89,"phoneExt":34,"email":74},"+45 42 63 33 59",{"type":66,"investigatorFullName":91,"investigatorTitle":92,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Andreas Mæchel Fritzen","Associate Professor",[94,97,99],{"name":95,"class":96},"Copenhagen Neuromuscular Center","UNKNOWN",{"name":98,"class":96},"Center of Inherited Metabolic Diseases, Copenhagen University Hospital Rigshospitalet",{"name":100,"class":96},"Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark","100563966",false,"NCT06623032","Metabolic Effects of Medium-Chain Fatty Acids in Patients With Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals","MEMCADD","Inclusion Criteria MCADD patients:\n\n* Male or female\n* Age between 18-80 years old\n* Diagnosed Medium-chain acyl-CoA dehydrogenase deficiency (MCADD\n\nInclusion Criteria Healthy Participants:\n\n* Male or female\n* Age between 18-80 years old\n\nExclusion Criteria both MCADD patients and healthy participants:\n\n* Diabetes\n* Kidney- or liver disease\n* Use of beta blockers or diuretics\n* Pregnant, lactating or planning to become pregnant within the study period\n* Regular intake of substantial amounts of coconut oil, palm kernel oil or any other source abundant in MCFA\n* Ongoing cancer treatment\n* Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption\n* Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible",true,"ALL","18 Years","80 Years",{"count":112,"type":113},30,"ESTIMATED","INTERVENTIONAL",[116],"NA","The aim of this project is to investigate the physiological effects of intake of long-chain fatty acids (LCFA) and medium-chain fatty acids (MCFA) in patients with Medium-Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) and healthy individuals",[119],"Medium-chain Acyl-CoA Dehydrogenase Deficiency",[121,122,123,56,60],"MCADD","Lipid metabolism","Ketone bodies","2026-03-09",{"date":126,"type":127},"2026-03-10","ACTUAL",{"date":129,"type":127},"2024-10-18",{"date":131,"type":113},"2027-09",{"name":5,"class":6},1]