[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595334":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":32,"responsibleParty":47,"collaborators":10,"id":51,"slug":10,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Helsinki University Central Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Controlled Asthma",null,"Children with asthma without need to intensify asthma treatment",{"label":13,"type":10,"description":14,"interventionNames":10},"Unocontrolled Asthma","Children with asthma and need to intensify their asthma treatment",{"label":16,"type":10,"description":17,"interventionNames":10},"Controlls","Children without asthmatic symptoms and medication",[19],{"name":20,"affiliation":21,"role":22},"Mika Mäkelä, Professor, PhD, MD","HUS","STUDY_CHAIR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Janne Burman, PhD, MD","CONTACT","+358406517912","janne.burman@hus.fi",{"name":30,"role":26,"phone":10,"phoneExt":10,"email":31},"Anssi Koivuselkä, Nurse","anssi.koivuselka@hus.fi",[33],{"facility":34,"status":35,"city":36,"state":10,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"HUS Skin and Allergy Hospital","RECRUITING","Helsinki","00250","Finland",{"type":40,"coordinates":41},"Point",[42,43],24.93545,60.16952,{"lat":43,"lon":42},[46],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Janne Burman","PhD, MD, Pediatric Allergist","100595334",false,"NCT07031102","Methacholine Challenge Test in School Children With\u002FWithout Asthma RISKA","RISKA: Respiratory Irritability With School Kids With\u002FWithout Asthma - Assessment of Methacholine Responsiveness in Pediatric Asthma: A Comparative Study With Healthy Controls","RISKA","Inclusion Criteria: Healthy Controls\n\n* • Aged 7-15 years, both sexes\n\n  * No diagnosis of asthma in childhood\n  * No inhaled asthma medication during the previous 2 years\n  * No wheezing or shortness of breath during the previous 2 years\n  * Written informed consent from the participant and guardian\n\nInclusion Criteria: Children with Asthma\n\n* Aged 7-15 years, both sexes\n* Physician-diagnosed asthma (ICD-10 codes J45.0\u002FJ45.1\u002FJ45.9)\n* Inhaled corticosteroid treatment for at least 6 months\n* Either:\n\n  * Well-controlled asthma (c-ACT\u002FACT score ≥20) and no clinical need to intensify medication, or\n  * Poorly controlled asthma with physician-confirmed need for intensified asthma medication\n\nExclusion Criteria:\n\n* • Premature birth before 32 gestational weeks\n\n  * Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma)\n  * Severe underlying illness such as malignancy\n  * Beta-blocker medication\n  * Active immunological disease",true,"ALL","7 Years","15 Years",{"count":63,"type":64},260,"ESTIMATED","OBSERVATIONAL","The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.",[68,69,70],"Asthma Bronchiale","Lung Function Tests","Bronchial Hyperresponsiveness",[72,73,74,75,76],"Asthma","Lung function test","children","Methacholine challange test","Bronchial provocation test","2025-06-12",{"date":79,"type":80},"2025-06-22","ACTUAL",{"date":82,"type":80},"2024-11-06",{"date":84,"type":64},"2027-12",{"name":5,"class":6},1]