The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness. The main questions it aims to answer are:
Use the neuropsychological paradigm model to monitor micro-movements, assess the patient's remaining level of consciousness and accurately classify it; screen out patients with cognitive-motor dissociation to improve the prognosis of cognitive function; explore the remaining brain function of patients with chronic disorders of consciousness and promote relevant study of neural mechanisms.
Participants will be subjected to consciousness assessment by CRS-r scale, and their micro-movement changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.
Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;
Aged between 18 and 80 years;
Stable vital signs;
Voluntary participation of family members with signed informed consent;
Locked-in syndrome;
Contraindications for EEG examination;
Contraindications for MRI scanning, such as the presence of internal metallic implants;
Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.
First Affiliated Hospital of Zhejiang University
Lead sponsor
Hangzhou Mingzhou Brain Rehabilitation Hospital
Collaborator
Zhejiang Provincial Armed Police Corps Hospital
Collaborator