[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547318":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":32,"responsibleParty":46,"collaborators":48,"id":54,"slug":10,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"First Affiliated Hospital of Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"DoC patients",null,"patients with disorders of consciousness",[13],"Diagnostic Test: micro-movement; electroencephalogram; MRI",{"label":15,"type":10,"description":16,"interventionNames":17},"healthy controls","healthy participants matched by gender and age",[13],[19],{"type":20,"name":21,"description":21,"armGroupLabels":22,"otherNames":10},"DIAGNOSTIC_TEST","micro-movement; electroencephalogram; MRI",[9,15],[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Zhuolin He","CONTACT","15990049962","hezhuolin@zju.edu.cn",{"name":30,"role":26,"phone":10,"phoneExt":10,"email":31},"Benyan Luo","luobenyan@zju.edu.cn",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"cosmosGeoPoint":10,"geoPoint":10,"contacts":40},"First Affiliated Hospital,Zhejiang University","RECRUITING","Hanzhou","Zhejiang","310003","China",[41,43],{"name":42,"role":26,"phone":27,"phoneExt":10,"email":28},"Zhuolin He, BA",{"name":44,"role":45,"phone":10,"phoneExt":10,"email":10},"Benyan Luo, PhD","PRINCIPAL_INVESTIGATOR",{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[49,52],{"name":50,"class":51},"Hangzhou Mingzhou Brain Rehabilitation Hospital","UNKNOWN",{"name":53,"class":51},"Zhejiang Provincial Armed Police Corps Hospital","100547318",false,"NCT06406413","Micro-movements in Patients With Prolonged Disorders of Consciousness","Study of Micro-movements in Patients With Prolonged Disorders of Consciousness","Inclusion Criteria:\n\n1. Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;\n2. Aged between 18 and 80 years;\n3. Stable vital signs;\n4. Voluntary participation of family members with signed informed consent;\n5. Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs.\n\nExclusion Criteria:\n\n1. Locked-in syndrome;\n2. Contraindications for EEG examination;\n3. Contraindications for MRI scanning, such as the presence of internal metallic implants;\n4. Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.",true,"ALL","18 Years","80 Years",{"count":65,"type":66},179,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness. The main questions it aims to answer are:\n\nUse the neuropsychological paradigm model to monitor micro-movements, assess the patient's remaining level of consciousness and accurately classify it; screen out patients with cognitive-motor dissociation to improve the prognosis of cognitive function; explore the remaining brain function of patients with chronic disorders of consciousness and promote relevant study of neural mechanisms.\n\nParticipants will be subjected to consciousness assessment by CRS-r scale, and their micro-movement changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.",[70],"Consciousness Disorders",[72,73,74,75,76],"disorders of consciousness","consciousness disorders","micro-movement","consciousness","Multidimensional paradigm stimulation","2026-01-13",{"date":79,"type":80},"2026-01-14","ACTUAL",{"date":82,"type":80},"2024-05-01",{"date":84,"type":66},"2026-12",{"name":5,"class":6},1]