[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607797":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":21,"id":59,"slug":21,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":21,"enrollmentInfo":68,"targetDuration":21,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":21,"overallStatus":77,"whyStopped":21,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"French Cardiology Society","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ultrasound localization microscopy","EXPERIMENTAL","The research protocol is integrated into the patient's routine preoperative visit. During this visit, the patient undergoes echocardiography and Doppler ultrasound of the supra-aortic trunks combined with transcranial Doppler. The use of microbubbles (SonoVue®) as a contrast agent is common in cases of poor visualization. We propose to add dedicated ultrasound localization microscopy sequences coupled with SonoVue® injection during this examination in order to image the circle of Willis and the coronary arteries.",[13,14],"Device: Ultrasound localization microscopy, circle of Willis","Device: Ultrasound localization microscopy, coronary arteries",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DEVICE","Ultrasound localization microscopy, circle of Willis","Ultrasound localization microscopy sequences coupled with SonoVue® injection of the circle of Willis before carotid endarterectomy",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Ultrasound localization microscopy, coronary arteries","ultrasound localization microscopy sequences coupled with SonoVue® injection of coronary arteries before carotid endarterectomy",[9],[27,31],{"name":28,"affiliation":29,"role":30},"Guillaume GOUDOT, MD","APHP, Georges Pompidou European Hospital, France","STUDY_CHAIR",{"name":32,"affiliation":33,"role":34},"Clément PAPADACCI, PhD","Institut National de la Santé Et de la Recherche Médicale, France","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":21,"email":40},"Tessa BERGOT, MSc","CONTACT","+33 1 44 90 70 33","tessa.bergot@sfcardio.fr",[42],{"facility":43,"status":21,"city":44,"state":21,"zip":45,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Georges Pompidou European Hospital","Paris","75015","France",{"type":48,"coordinates":49},"Point",[50,51],2.3488,48.85341,{"lat":51,"lon":50},[54],{"name":28,"role":38,"phone":55,"phoneExt":21,"email":56},"+33 1 56 09 30 51","guillaume.goudot@aphp.fr",{"type":58,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100607797",false,"NCT07193225","Microflow3D - Non-invasive Mapping of Coronary Arteries and the Cerebral Vascular Network Using 3D Ultrasound Localization Microscopy in Patients With Atherosclerosis Prior to Carotid Endarterectomy Surgery","Non-invasive Mapping of Coronary Arteries and the Cerebral Vascular Network Using 3D Ultrasound Localization Microscopy in Patients With Atherosclerosis Prior to Carotid Endarterectomy Surgery - Microflow3D","Microflow3D","Inclusion Criteria:\n\n* Patients with asymptomatic carotid stenosis, without recent stroke, and scheduled for carotid endarterectomy within the next 30 days.\n* Age ≥ 18 years.\n* Beneficiary of a social security system or equivalent coverage.\n* Signed informed consent.\n* Patients already enrolled in another biomedical research study may also participate in this study.\n\nExclusion Criteria:\n\n* Contraindication to the use of the ultrasound contrast agent SonoVue®: known hypersensitivity to the active substance or to any of the following excipients: Macrogol 4000; Distearoylphosphatidylcholine; Sodium dipalmitoylphosphatidylglycerol; Palmitic acid.\n* Allergy to ultrasound gel.\n* Refusal or inability (linguistic or psychological) to sign the informed consent form.\n* Subject to legal protection measures, such as guardianship (in accordance with Article L1122-2 of the French Public Health Code).\n* Pregnant or breastfeeding women cannot participate in this study.","ALL","18 Years",{"count":69,"type":70},37,"ESTIMATED","INTERVENTIONAL",[73],"NA","There is a need to simplify the assessment of coronary and cerebral vascular networks in patients selected for carotid endarterectomy in order to prevent potential complications during and after surgery. A non-invasive, non-ionizing 3 dimension mapping of these networks would provide a remarkable benefit for patients.",[76],"Carotid Atherosclerosis","NOT_YET_RECRUITING","2025-09-18",{"date":80,"type":81},"2025-09-25","ACTUAL",{"date":83,"type":70},"2025-11-01",{"date":85,"type":70},"2027-11-30",{"name":5,"class":6},1]