[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591434":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":122,"collaborators":124,"id":134,"slug":26,"hasResults":135,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":26,"eligibilityCriteria":139,"healthyVolunteers":140,"sex":141,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":26,"studyType":147,"phases":148,"briefSummary":150,"conditions":151,"keywords":26,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":162},{"fullName":5,"class":6},"a2 Milk Company Ltd.","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"a2 UHT Milk","ACTIVE_COMPARATOR","containing A2 type β-casein only (A1PF)",[13],"Other: a2 UHT milk",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional UHT milk","PLACEBO_COMPARATOR","containing both A1 and A2 type β-caseins (CON)",[19],"Other: Conventional UHT Milk",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"OTHER","a2 UHT milk","Pregnant women in this arm will drink a2 UHT Milk twice a day, 200ml each time, until study completion. Their infants will be fed with the mother's breastmilk exclusively.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional UHT Milk","Pregnant women in this arm will drink conventional UHT Milk twice a day, 200ml each time, until study completion. Their infants will be fed with the mother's breastmilk exclusively.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Fen Xie","CONTACT","86 510 88682959","jndxfygcp@163.com",[38,56,70,85,93,107],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Foshan Maternity & Child Healthcare Hospital","RECRUITING","Foshan","Guangdong","528000","China",{"type":46,"coordinates":47},"Point",[48,49],113.13148,23.02677,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":55},"Yao Fu","+86-757-22978072","124166604@qq.com",{"facility":57,"status":40,"city":58,"state":42,"zip":59,"country":44,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Panyu Maternal and Child Care Service Centre of Guangzhou","Guangzhou","511400",{"type":46,"coordinates":61},[62,63],113.25,23.11667,{"lat":63,"lon":62},[66],{"name":67,"role":34,"phone":68,"phoneExt":26,"email":69},"Guoliang He","+86 20 3915 9963","pyfygcp@163.com",{"facility":71,"status":40,"city":72,"state":73,"zip":74,"country":44,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Wuxi Maternal and Child Health Hospital","Wuxi","Jiangsu","214002",{"type":46,"coordinates":76},[77,78],120.28857,31.56887,{"lat":78,"lon":77},[81],{"name":82,"role":34,"phone":83,"phoneExt":26,"email":84},"Yan Sun","+86-510-68004318","wxfuyou@126.com",{"facility":86,"status":40,"city":72,"state":73,"zip":87,"country":44,"cosmosGeoPoint":88,"geoPoint":90,"contacts":91},"Affiliated hospital of Jiangnan University","214122",{"type":46,"coordinates":89},[77,78],{"lat":78,"lon":77},[92],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"facility":94,"status":40,"city":95,"state":73,"zip":96,"country":44,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Xuzhou Maternal and Child Health Hospital","Xuzhou","221009",{"type":46,"coordinates":98},[99,100],117.28386,34.20442,{"lat":100,"lon":99},[103],{"name":104,"role":34,"phone":105,"phoneExt":26,"email":106},"Shuai Zhao","+85 516 8390 7537","xfirb@163.com",{"facility":108,"status":40,"city":109,"state":110,"zip":111,"country":44,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"First People's Hospital of Chengdu","Chengdu","Sichuan","610041",{"type":46,"coordinates":113},[114,115],104.06667,30.66667,{"lat":115,"lon":114},[118],{"name":119,"role":34,"phone":120,"phoneExt":26,"email":121},"Juan Zhou","+86 28 85223984","cdsyyyll@163.com",{"type":123,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[125,128,130,132],{"name":126,"class":127},"Edanz Inc","UNKNOWN",{"name":129,"class":127},"Cyanth (Wuxi) Health Technology Co. Ltd.",{"name":131,"class":127},"Affilicated Hospital of Jiangnan University",{"name":133,"class":127},"Guangzhou Trials Medical","100591434",false,"NCT06980376","Milk Free From A1-Type β-Casein on Inflammation, Gastrointestinal Tolerance, and Pregnancy Outcomes","Effects of Milk Free From A1-Type β-Casein on Inflammation, Gastrointestinal Tolerance, and Pregnancy Outcomes: A Multi-Centre, Randomised, Open-Label, Prospective Study","Inclusion Criteria:\n\n* 20-35 years of age\n* Recruited at \\\u003C12 weeks of gestation\n* Intention to deliver at study site hospital\n* Singleton pregnancy\n* Able and willing to consume milk during pregnancy\n* Agree not to participate in another interventional clinical study during the present study\n\nExclusion Criteria:\n\n* Body mass index ≥ 35 at enrolment\n* Cow's milk intolerance or allergy\n* Significant systemic disorder (e.g., cardiac, respiratory, endocrinological, hemato-logic, or GI); pre-pregnancy diabetes, hypertension, or other medical conditions that preclude participation per the investigator's judgement\n* Taking any prescribed chronic medications\n* Participation in another clinical trial\n* Investigator uncertainty about the willingness or ability of the participant to comply with the protocol requirements\n* Taking probiotics at screening or two weeks before enrolment\n* Receiving any vaccine at screening or two weeks before enrolment",true,"FEMALE","20 Years","35 Years",{"count":145,"type":146},100,"ESTIMATED","INTERVENTIONAL",[149],"NA","The aim of the study is to compare the effects of conventional Ultra High Temperature (UHT) milk containing both A1 and A2 type β-caseins (CON) with a2 UHT Milk containing A2 type β-casein only (A1PF) on inflammation, tolerance, and GI symptoms in pregnant women as well as infants' birth outcomes from 12 weeks' gestation up to 40 days post-birth.",[152],"Healthy Pregnant Women","2026-02-04",{"date":155,"type":156},"2026-02-06","ACTUAL",{"date":158,"type":156},"2025-08-25",{"date":160,"type":146},"2026-09",{"name":5,"class":6},6]