[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100486701":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":26,"locations":35,"responsibleParty":70,"collaborators":73,"id":77,"slug":25,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":25,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Columbia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"15-Minute mbNF","ACTIVE_COMPARATOR","Participants receiving mindfulness training and 15-minute session of mbNF",[13],"Other: Mindfulness + fMRI Neurofeedback",{"label":15,"type":10,"description":16,"interventionNames":17},"30-Minute mbNF","Participants receiving mindfulness training and 30-minute session of mbNF",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Mindfulness + fMRI Neurofeedback","Prior to neurofeedback, participants will receive 45 minutes of mindfulness training. Participants will then receive mindfulness-based fMRI neurofeedback targeting the default mode network and frontoparietal control network.",[9,15],[24],"Mindfulness-based Real-time fMRI Neurofeedback",null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Randy P Auerbach, PhD","CONTACT","646-774-5745","rpa2009@cumc.columbia.edu",{"name":33,"role":29,"phone":25,"phoneExt":25,"email":34},"Simryn Molina, BA","simryn.molina@nyspi.columbia.edu",[36,55],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Northeastern University","RECRUITING","Boston","Massachusetts","02115","United States",{"type":44,"coordinates":45},"Point",[46,47],-71.05977,42.35843,{"lat":47,"lon":46},[50,53],{"name":51,"role":29,"phone":25,"phoneExt":25,"email":52},"Susan Whitfield-Gabrieli, PhD","s.whitfield-gabrieli@northeastern.edu",{"name":51,"role":54,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"facility":56,"status":38,"city":57,"state":57,"zip":58,"country":42,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Columbia University Irving Medical Center","New York","10032",{"type":44,"coordinates":60},[61,62],-74.00597,40.71427,{"lat":62,"lon":61},[65,66,68],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},{"name":67,"role":29,"phone":25,"phoneExt":25,"email":25},"Randy P Auerbach",{"name":69,"role":54,"phone":25,"phoneExt":25,"email":25},"Randy Auerbach, PhD",{"type":54,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Randy P. Auerbach, Ph.D., ABPP","Professor",[74],{"name":75,"class":76},"National Institute of Mental Health (NIMH)","NIH","100486701",false,"NCT05617495","Mindfulness-Based fMRI Neurofeedback for Depression","Targeting Adolescent Depression Symptoms Using Network-based Real-time fMRI Neurofeedback and Mindfulness Meditation (NIMH); Mindfulness-Based Real-Time fMRI Neurofeedback for Depression (IRB)","mbNF","Inclusion Criteria:\n\n* Ages 13-18 years-old\n* Written informed assent\u002Fconsent and parental\u002Fguardian permission for 13-17 year-olds or informed consent for 18 year-olds\n* Tanner puberty stage ≥3\n* Meets current diagnostic criteria for MDD\n* English fluency\n\nExclusion Criteria:\n\n* Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorders\n* Substance use disorder, moderate or severe in past 6 months\n* Active suicidal ideation with a specific plan\n* History of seizure disorder\n* Medical or neurological illness (e.g., severe head injury)\n* MRI contraindications\n* Current psychotropic medication use other than antidepressant medication\n* Intelligence quotient (IQ) \\\u003C80.","ALL","13 Years","18 Years",{"count":88,"type":89},90,"ESTIMATED","INTERVENTIONAL",[92],"NA","In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.",[95,96],"Depression in Adolescence","Rumination",[98,99,96,100],"Real-time fMRI Neurofeedback","Mindfulness","Major Depressive Disorder","2026-04-24",{"date":103,"type":104},"2026-04-29","ACTUAL",{"date":106,"type":104},"2024-04-10",{"date":108,"type":89},"2027-06-30",{"name":5,"class":6},2]