[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570771":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":11,"studyPopulation":27,"armGroups":11,"interventions":28,"overallOfficials":33,"centralContacts":37,"locations":42,"responsibleParty":58,"collaborators":61,"id":64,"slug":11,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":11,"eligibilityCriteria":68,"healthyVolunteers":65,"sex":69,"minAge":11,"maxAge":11,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":11,"briefSummary":74,"conditions":75,"keywords":11,"overallStatus":45,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Shandong University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":15,"otherOutcomes":11},[9,13],{"measure":10,"description":11,"timeFrame":12},"Clearance (L\u002Fh)",null,"Through study completion, an average of 30 days",{"measure":14,"description":11,"timeFrame":12},"Volume of Distribution (L)",[16,19,22],{"measure":17,"description":18,"timeFrame":12},"the ratio of the area under the concentration-time curve from 0 to 24 hours","For time-dependent antimicrobials, the PD target is defined as the time of free drug concentration beyond MIC during the dose interval. For concentration-dependent antimicrobials, the PD target is defined as the ratio of the area under the concentration-time curve from 0 to 24 hours to the MIC.",{"measure":20,"description":21,"timeFrame":12},"erythrocyte sedimentation rate","Clinical treatment outcome",{"measure":23,"description":11,"timeFrame":12},"Adverse events",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":25,"timePerspective":26,"maskingInfo":11},"COHORT","PROSPECTIVE","Patients with suspected\u002Fconfirmed spinal infections who are undergoing anti-infective drug therapy.",[29],{"type":30,"name":31,"description":32,"armGroupLabels":11,"otherNames":11},"DRUG","Anti-Infective Drugs","Anti-infective drugs are administered using the traditional clinical dosing regimen, with no interventions.",[34],{"name":35,"affiliation":5,"role":36},"Wei Zhao, Ph.D","PRINCIPAL_INVESTIGATOR",[38],{"name":35,"role":39,"phone":40,"phoneExt":11,"email":41},"CONTACT","8653188383308","zhao4wei2@hotmail.com",[43],{"facility":44,"status":45,"city":46,"state":11,"zip":11,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Shandong Public Health Clinical Center","RECRUITING","Jinan","China","CN",{"type":50,"coordinates":51},"Point",[52,53],116.99722,36.66833,{"lat":53,"lon":52},[56],{"name":57,"role":39,"phone":11,"phoneExt":11,"email":11},"Qiang Zhang",{"type":36,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Wei Zhao","Head of department of clinical pharmacy and pharmacology",[62],{"name":44,"class":63},"OTHER_GOV","100570771",false,"NCT06711575","Model-informed Individualized Treatment of Anti-Infective Drugs in Patients With Spinal Infections","Inclusion Criteria:\n\n* Patients with suspected\u002Fconfirmed spinal infections who are undergoing anti-infective drug therapy.\n\nExclusion Criteria:\n\n* Pregnant\u002Flactating women.\n* There are other factors that the researchers think are not suitable for inclusion","ALL",{"count":71,"type":72},300,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to describe the population pharmacokinetic characteristics in patients with suspected\u002Fconfirmed spinal infections who are undergoing anti-infective drug therapy, and to evaluate effectiveness and safety of these drugs.",[76],"Infectious Diseases of Spine","2024-11-29",{"date":79,"type":80},"2024-12-02","ACTUAL",{"date":82,"type":80},"2024-10-12",{"date":84,"type":72},"2026-10-01",{"name":5,"class":6},1]