[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100509991":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":34,"responsibleParty":91,"collaborators":94,"id":99,"slug":12,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":100,"sex":106,"minAge":107,"maxAge":12,"enrollmentInfo":108,"targetDuration":12,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":12,"overallStatus":37,"whyStopped":12,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"University Hospital, Geneva","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Moderate alcohol consumption","NO_INTERVENTION","1 standard unit a day for 3 months",null,{"label":14,"type":6,"description":15,"interventionNames":16},"Abstinence","No alcohol beverages for 3 months",[17],"Behavioral: Alcohol consumption",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"BEHAVIORAL","Alcohol consumption","After written consent, patients will enter a run-in period of 2 weeks where they will be asked not to drink any alcohol beverage. Patients with a successful run-in period will be randomized on a 1:1 basis stratified by baseline LVEF (\\\u003C50% vs. ≥50%), sex and study site. 110 patients will be assigned to moderate alcohol consumption (1 standard unit a day), and 110 patients to abstinence (no alcohol beverages) for 3 months. We will perform a first echocardiography at randomization and a second at 3 months' follow-up.",[14],[25],{"name":26,"affiliation":27,"role":28},"Baris Gencer, MD","CHUV","PRINCIPAL_INVESTIGATOR",[30],{"name":26,"role":31,"phone":32,"phoneExt":12,"email":33},"CONTACT","+41 79 556 59 60","baris.gencer@chuv.ch",[35,51,65,78],{"facility":36,"status":37,"city":38,"state":38,"zip":39,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Universitätsspital Basel","RECRUITING","Basel","4031","Switzerland",{"type":42,"coordinates":43},"Point",[44,45],7.57327,47.55839,{"lat":45,"lon":44},[48],{"name":49,"role":31,"phone":12,"phoneExt":12,"email":50},"Christian Müller, Prof Dr","Christian.Mueller@usb.ch",{"facility":52,"status":37,"city":53,"state":54,"zip":55,"country":40,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Inselspital","Bern","Canton of Bern","3010",{"type":42,"coordinates":57},[58,59],7.44744,46.94809,{"lat":59,"lon":58},[62],{"name":63,"role":31,"phone":12,"phoneExt":12,"email":64},"Lorenz Raber","lorenz.raeber@insel.ch",{"facility":66,"status":37,"city":67,"state":68,"zip":69,"country":40,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Centre hospitalier universitaire vaudois","Lausanne","Canton of Vaud","1005",{"type":42,"coordinates":71},[72,73],6.63282,46.516,{"lat":73,"lon":72},[76],{"name":77,"role":31,"phone":12,"phoneExt":12,"email":33},"Baris Gencer",{"facility":79,"status":37,"city":80,"state":12,"zip":81,"country":40,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Hôpitaux Universitaires de Genève","Geneva","1205",{"type":42,"coordinates":83},[84,85],6.14569,46.20222,{"lat":85,"lon":84},[88],{"name":89,"role":31,"phone":12,"phoneExt":12,"email":90},"François Mach","francois.mach@hug.ch",{"type":92,"investigatorFullName":77,"investigatorTitle":93,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"SPONSOR_INVESTIGATOR","Principal Investigator",[95,97],{"name":96,"class":6},"University of Bern",{"name":98,"class":6},"Swiss National Science Foundation","100509991",false,"NCT05920629","Moderate Alcohol Consumption and Heart Function in Patients With a Recent Myocardial Infarction","Moderate Alcohol Consumption and Heart Function in Patients With a Recent Myocardial Infarction: a Multicentre Randomized Controlled Trial","Moderate","Inclusion Criteria:\n\n* Hospitalization for acute ST-elevation MI (STEMI) or non ST-elevation MI (NSTEMI) within 365 days prior to screening\n* Men and women aged ≥18 years who are capable and willing to provide consent\n* ECG ischemic changes, such as persistent or dynamic ST-segment deviation\n* Evidence of positive high-sensitive troponin\n* Confirmation of coronary heart disease aetiology by angiography\n* Capacity to complete study visits with strict adherence to the protocol assignment\n* Self-reported average alcohol consumption of between 1 and 28 standard units per week in the 12 months prior to the index hospitalization.\n\nExclusion Criteria:\n\n* High alcohol consumption, defined as an average of \\>28 alcoholic standard units\u002Fweek in the 12 months prior to the index hospitalization\n* Alcohol use disorder (AUDIT score \\>20 at screening)\n* History of alcohol or substance abuse\n* Naïve to alcohol consumption\n* Light alcohol consumption (\\\u003C1 standard units by week)\n* Prior severe heart failure (NYHA III-IV)\n* Severe LV dysfunction at screening (\\\u003C30%)\n* History of gastric ulcer or gastro-intestinal bleeding\n* Serious chronic liver disease or liver test elevation (\\> 3 times upper limit normal range)\n* Personal history of any colon or liver cancer\n* Any active malignancy (less than 5 years or ongoing treatment)\n* Estimated glomerular filtration rate 15 ml\u002Fmin\u002F1.73m² or end-stage renal disease\n* Any medication (investigator's discretion) making study participation impractical or precluding required follow-up\n* History of organ transplant\n* Participation in another trial testing intervention on similar CV outcomes (investigator's discretion)\n* Any medical, geographic, or social factor making study participation impractical or precluding required follow-up.\n* Pregnant, breastfeeding or planning to become pregnant within 12 months.","ALL","18 Years",{"count":109,"type":110},220,"ESTIMATED","INTERVENTIONAL",[113],"NA","A total of 220 patients (110 per arm) who report moderate alcohol consumption between 1 and 28 standard units (1 standard unit = \\~10 grams) per week in the 12 months prior to hospital admission will be planned for randomization, using a 1:1 ratio to pursue moderate alcohol consumption (1 standard unit per day for women and 2 standard units per day for men) or abstinence (except for one drink on predefined\u002Fagreed special occasions) for a total duration of 3 months. An echocardiography will be performed at baseline and 3 months to assess changes in systolic cardiac function (LVEF) for the primary endpoint. A core laboratory team blinded to assignment will perform data interpretation.",[116],"Myocardial Infarction","2026-04-22",{"date":119,"type":120},"2026-04-28","ACTUAL",{"date":122,"type":120},"2023-06-01",{"date":124,"type":110},"2026-04-30",{"name":77,"class":6},4]