[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462840":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":52,"collaborators":20,"id":54,"slug":20,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":20,"enrollmentInfo":63,"targetDuration":20,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"blood sampling","EXPERIMENTAL","blood sample (2 tubes of 7.5 mL of blood = 15 mL) during the preoperative check-up on the day of the ultrasound-bronchoscopy in order to compare the sensitivity of the analysis of free circulating DNA present in the supernatant of pulmonary nodules less than 20 mm samples taken under ultrasound-bronchoscopy to that present in the plasma",[13],"Biological: Blood samples",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BIOLOGICAL","Blood samples","Patients will be taken from an additional blood sample (2 tubes of 7.5 mL of blood = 15 mL) during the preoperative check-up on the day of the ultrasound-bronchoscopy in order to compare the sensitivity of the analysis of free circulating DNA present in the supernatant of pulmonary nodules less than 20 mm samples taken under ultrasound-bronchoscopy to that present in the plasma.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Valentin HELUAIN, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":29,"email":30},"CONTACT","+33567771439","+33","heluain.v@chu-toulouse.fr",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Toulouse University Hospital","RECRUITING","Toulouse","Occitanie","31300","France",{"type":40,"coordinates":41},"Point",[42,43],1.44367,43.60426,{"lat":43,"lon":42},[46,50],{"name":47,"role":27,"phone":48,"phoneExt":20,"email":49},"Sandra BERNARD, PM","+33561778573","bernard.s@chu-toulouse.fr",{"name":51,"role":24,"phone":20,"phoneExt":20,"email":20},"Valentin HELUAIN",{"type":53,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100462840",false,"NCT05306912","Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules","Molecular Analysis of Endoscopic Cytology Samples Supernatant in Pulmonary Nodules (Cancer Or Benign Endoscopy) (KOBE)","KOBE","Inclusion Criteria:\n\n* rEBUS bronchoscopy planned for one, two or three ≤ 20 mm nodule\n* World Health Organization (WHO) Performance status 0-3\n* Informed signed consent\n* Patient affiliated or beneficiary of a social security scheme (Social Security or Universal Medical Coverage).\n\nExclusion Criteria:\n\n* Lung cancer diagnosed before the date of the procedure\n* Lung cancer strongly suspected due to mediastinal or extra thoracic lesions\n* Patient under State Medical Assistance\n* Patient deprived of liberty on administrative or judicial decision, or patient under guardianship, curators or safeguard of justice","ALL","18 Years",{"count":64,"type":65},60,"ESTIMATED","INTERVENTIONAL",[68],"NA","Lung cancer screening is based on low dose CT scan (LDCT), a highly sensitive but poorly specific tool.\n\nComplementary specific approaches are thus strongly needed, among which cell-free DNA (cfDNA) genotyping has been proven highly specific but of low sensitivity (25 to 50% for stage I diseases) due to inconstant tumor shed. Tumor biopsy is thus often required and radial endobronchial ultrasound (rEBUS) bronchoscopy is a minimally invasive approach (\\\u003C3% complications) but of limited sensitivity in cases of nodules \\\u003C 20 mm.\n\nThe investigators hypothesized that methylation analysis on cfDNA floating in supernatant derived from rEBUS specimens could improve rEBUS sensitivity",[71,72],"Lung Cancer","Lung; Node",[74,75,76,77,78,79,80],"Circulating free DNA","Methylation","Lung cancer","screening","lung nodule","radial EBUS","endobronchial ultrasound","2026-04-28",{"date":83,"type":84},"2026-04-29","ACTUAL",{"date":86,"type":84},"2022-04-08",{"date":88,"type":65},"2026-12",{"name":5,"class":6},1]