Microvascular inflammation in kidney allografts has been widely reappraised in the recent update of Banff classification. There is a critical need to better understand the pathophysiological mechanisms associated with the various phenotypes of microvascular inflammation that are observed in kidney transplants, particularly in order to develop targeted therapeutic approaches.
None
Inadequate biopsy according to the Banff classification
Missing data for Banff lesion scores, donor-specific antibody status, C4d staining
Biopsies showing histological signs of ischemia-reperfusion
Combined transplantation and kidney transplantation after a non-kidney solid organ transplantation
Adult kidney transplant recipients of all sexes (self-determined) recruited in Europe and United States, who had a kidney allograft biopsy with or without lesions of microvascular inflammation (adequate biopsies without missing data for Banff lesion scores, donor-specific antibody status, and C4d staining), according to the international Banff 2022 classification.
Cohort
Prospective
No intervention
Other interventionNo intervention
RNA-based molecular signatures assessed using bulk and spatial transcriptomics
Probability of graft survival based on outcome data
Probability of patient survival on outcome data
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