[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596479":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":17,"armGroups":18,"interventions":24,"overallOfficials":13,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":13,"id":54,"slug":13,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":13,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":13,"studyType":66,"phases":13,"briefSummary":67,"conditions":68,"keywords":13,"overallStatus":70,"whyStopped":13,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Skye Biologics Holdings, LLC","INDUSTRY",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Graft Maturation via MRI","The signal to noise ratio will be calculated at the proximal, mid-substance, and distal positions of the graft","From 4.5 months post surgery until 12 months or graft maturation.",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","Subject who received primary ACL surgery at Houston Methodist Sugar Land.",[19],{"label":20,"type":13,"description":21,"interventionNames":22},"ACL Reconstruction with Allograft","Subjects who have undergone ACL reconstruction with allograft",[23],"Diagnostic Test: MRI",[25],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":13},"DIAGNOSTIC_TEST","MRI","MRI to assess graft maturation",[20],[31],{"name":32,"role":33,"phone":34,"phoneExt":13,"email":35},"Kyle Borque, MD","CONTACT","281-690-4678","kaborque@houstonmethodist.org",[37],{"facility":38,"status":13,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Houston Methodist Sugar Land","Sugar Land","Texas","77479","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-95.63495,29.61968,{"lat":48,"lon":47},[51],{"name":32,"role":33,"phone":34,"phoneExt":13,"email":35},{"type":53,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100596479",false,"NCT07046000","MRI Evaluation of Graft Maturation Following ACL Reconstruction","Magnetic Resonance Imaging (MRI) Evaluation of Graft Maturation Following Anterior Cruciate Ligament (ACL) Reconstruction With a Connective Tissue Allograft","Inclusion Criteria:\n\n* ACL tear and reconstruction; no other knee ligaments needing reconstruction\n* Primary (first-time) ACL tear in the affected knee\n* ACL injury occurred less than 12 months before ACL reconstruction\n* Have no contraindications or allergies to the treatment administered\n* Have current imaging studies (plain radiographs and MRI exams within the past 12 months) of the knee to rule out other etiologic diagnoses\n* Patient underwent ACL reconstruction with a Bone-Patellar Tendon-Bone (BTB) graft harvested from the same knee (ipsilateral autograft) with the Active Matrix tissue\n* Able and willing to comply with the post-operative study follow-up schedule\n\nExclusion Criteria:\n\n* Prior surgery on the index knee within 12 months of enrollment\n* Steroid injection into the index knee within 6 weeks of enrollment\n* Chronic ACL tear whereas the injury occurred more than 12 months ago\n* Multiligamentous injuries whereas any ligament (MCL, PCL, or PLC) in addition to the ACL needs to be reconstructed\n* Patient underwent ACL reconstruction with a hamstring tendon, Achilles tendon or quadriceps tendon graft (any graft other than a patellar tendon BTB)\n* Contraindication to MRI (eg, implanted devices incompatible with MRI).\n* Chrondral lesion of the knee that requires treatment during ACL reconstruction surgery\n* History of advanced osteoarthritis of the knee or patella-femoral joint; KL grade III or higher\n* History of malignant tumor and osseous metastatic disease,\n* History of chronic pain disorders (i.e., fibromyalgia),\n* Current substance abuse (drug or alcohol), by the investigator's judgment,\n* Females who are pregnant, nursing or breastfeeding, or who intend to become pregnant during participation in the study.\n* Currently participating in, or have been recently exited from (within 30 days from enrollment in this study), or plan to enroll in another clinical study for a bone allograft or drug that may impact participation or outcomes of this study,\n* Currently involved in any injury litigation or workers compensation claims,\n* Has a condition, disorder or other factor that, in the investigator's opinion, would interfere with study participation.","ALL","14 Years","50 Years",{"count":64,"type":65},10,"ESTIMATED","OBSERVATIONAL","Post-surgical ACL Graft maturation will be assessed at 4.5, 6, 7.5, 9, 10.5, and 12 months with MRI.",[69],"ACL Tears","NOT_YET_RECRUITING","2026-04-23",{"date":73,"type":74},"2026-04-24","ACTUAL",{"date":76,"type":65},"2026-08-01",{"date":78,"type":65},"2028-02",{"name":5,"class":6},1]