MRS Measurement of Glutamate and GABA Metabolism in Brain
ConditionNormal Physiology
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorNational Institute of Mental Health (NIMH)
About this trial
This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of \[13\]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA).
Eligibility criteria
Qualifiers
18-65 years of age
Able to give written informed consent
Healthy based on medical history and physical exam
Enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
Disqualifiers
Any current Axis 1 diagnosis
Clinically significant laboratory abnormalities
Positive HIV test
Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
Trial design
Treatments tested in this trial
- 3T and 7T device
Treatment groups
200 Participants
are divided into 1 treatment groupLocations
1National Institutes of Health Clinical Center20892, BethesdaMaryland, United States
Sponsors and collaborators
National Institute of Mental Health (NIMH)
Lead sponsor
Source ClinicalTrials.gov