[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611698":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":16,"locations":22,"responsibleParty":36,"collaborators":7,"id":40,"slug":7,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":7,"eligibilityCriteria":45,"healthyVolunteers":41,"sex":46,"minAge":47,"maxAge":7,"enrollmentInfo":48,"targetDuration":51,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":7,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},{"fullName":5,"class":6},"Shanghai Pulmonary Hospital, Shanghai, China","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"longitudinal changes in multi-omics profiling of peripheral blood","This study investigates the associations between longitudinal changes in multi-omics profiling of peripheral blood-including cell-free DNA, single-cell transcriptomics, proteomics, and metabolomics-and the development of acute lung allograft dysfunction(ALAD) and chronic lung allograft dysfunction(CLAD) in lung transplant recipients at various postoperative time points.",[13],{"name":14,"affiliation":5,"role":15},"Chang Chen, MD,PHD","PRINCIPAL_INVESTIGATOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":7,"email":21},"Junqi Wu","CONTACT","+8615618977421","wujunqi@tongji.edu.cn",[23],{"facility":24,"status":25,"city":26,"state":7,"zip":7,"country":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Shanghai Pulmonary Hospital","RECRUITING","Shanghai","China",{"type":29,"coordinates":30},"Point",[31,32],121.45806,31.22222,{"lat":32,"lon":31},[35],{"name":18,"role":19,"phone":20,"phoneExt":7,"email":21},{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"SPONSOR_INVESTIGATOR","Chang Chen","Professor","100611698",false,"NCT07243964","Multi-Omics-Based Prediction of Allograft Dysfunction After Lung Transplantation","Multi-Omics-Based Prediction of Allograft Dysfunction After Lung Transplantation: A Prospective, Multicenter Cohort Study","Inclusion Criteria:\n\n1. Recipients aged ≥18 years undergoing single or double lung transplantation;\n2. Postoperative recipients capable of understanding and providing written informed consent, and willing to comply with scheduled follow-ups and sample collections as required by the study;\n3. Postoperative recipients clinically assessed as stable and eligible for routine follow-up and hematological examinations;\n4. Recipients able to undergo dynamic pulmonary function monitoring during follow-up;\n5. No planned participation in other interventional trials during the study period that may impact immune function or pulmonary function;\n6. Retransplant patients will be considered as a new transplant event and may be included in the analysis.\n\nExclusion Criteria:\n\n1. History of active malignancy or presence of untreated malignancy within 5 years prior to transplantation;\n2. Presence of active systemic infection or significant immune rejection;\n3. Female patients who are pregnant or lactating;\n4. Any other condition deemed by the investigator to be inappropriate for inclusion .","ALL","18 Years",{"count":49,"type":50},244,"ESTIMATED","2 Years","OBSERVATIONAL","By establishing a prospective, multicenter lung transplantation clinical cohort, this study aims to systematically evaluate the utility of cfDNA fragmentomics, peripheral blood single-cell sequencing, and proteomics in monitoring and predicting graft dysfunction after lung transplantation, and to develop a multi-omics predictive model for early identification, dynamic monitoring, and mechanistic investigation of acute lung allograft dysfunction (ALAD) and chronic lung allograft dysfunction (CLAD).",[55],"Lung Diseases","2025-11-21",{"date":58,"type":59},"2025-11-24","ACTUAL",{"date":61,"type":59},"2025-11-01",{"date":63,"type":50},"2030-03-01",{"name":38,"class":6},1]