[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635930":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":11,"id":50,"slug":11,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":11,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":11,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":33,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TBS intervention targeting multiple targets (L-DLPFC, L-IPL, R-OFC)","ACTIVE_COMPARATOR",null,[13],"Device: repetitive transcranial magnetic stimulation (rTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","SHAM_COMPARATOR","Same targets, same TBS parameters, coil rotated 180°",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","repetitive transcranial magnetic stimulation (rTMS)","Repetitive transcranial magnetic stimulation (rTMS) is a recently developed neuromodulation technique.",[15,9],[26],{"name":27,"role":28,"phone":29,"phoneExt":11,"email":30},"Huiru Cui, Ph.D","CONTACT","+86 21 34773230","cuihuiru@163.com",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Shanghai","Shanghai Municipality","200030","China",{"type":39,"coordinates":40},"Point",[41,42],121.45806,31.22222,{"lat":42,"lon":41},[45],{"name":46,"role":28,"phone":47,"phoneExt":11,"email":30},"Huiru Cui","86 21 34773230",{"type":49,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100635930",false,"NCT07559084","Multi-target TMS for Schizophrenia Negative Symptoms","Development of a Multi-target Transcranial Magnetic Intervention Technique for Negative Symptoms of Schizophrenia","Inclusion Criteria:\n\n1. Outpatients or inpatients at the Department of Psychiatry, Shanghai Mental Health Center;\n2. Meet the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for first-episode schizophrenia (diagnosed using the Structured Clinical Interview for DSM-5, SCID-5); disease duration less than 5 years at enrollment;\n3. Male or female aged 16-45 years;\n4. Education duration ≥ 9 years;\n5. Stable medication regimen for at least 6 weeks prior to baseline visit and throughout the study period; psychiatric symptoms generally stable within 1 month prior to baseline visit;\n6. Participants and their guardians can understand and sign written informed consent;\n7. Total score on the PANSS Negative Symptom subscale (PANSS-N) \\> 15, and at least one item score ≥ 3.\n\nExclusion Criteria:\n\n1. Current or lifetime psychiatric disorders as determined by SCID-5 assessment;\n2. Severe or unstable physical illnesses, including: neurological disorders (delirium, dementia, stroke, epilepsy, migraine, etc.), congestive heart failure, angina pectoris, myocardial infarction, arrhythmia, hypertension, hyperglycemia, malignant tumors, and immunocompromised conditions;\n3. Alcohol abuse within 30 days prior to the study or alcohol\u002Fdrug dependence within 6 months prior to the study; participation in any clinical trial within 30 days prior to baseline;\n4. Pregnant or breastfeeding women;\n5. Intellectual disability (IQ \\\u003C 70).","ALL","16 Years","45 Years",{"count":60,"type":61},64,"ESTIMATED","INTERVENTIONAL",[64],"NA","This randomized controlled trial (RCT) is the first to evaluate the efficacy and safety of a multi-target TMS protocol targeting the left dorsolateral prefrontal cortex (L-DLPFC), left inferior parietal lobule (L-IPL), and right orbitofrontal cortex (R-OFC) for negative symptoms of schizophrenia.",[67],"SCHIZOPHRENIA 1 (Disorder)",[69,70,71,72,73],"schizophrenia","TMS","repetitive transcranial magnetic stimulation","rTMS","TBS","2026-04-26",{"date":76,"type":77},"2026-04-30","ACTUAL",{"date":79,"type":61},"2026-05-01",{"date":81,"type":61},"2028-01-30",{"name":5,"class":6},1]