[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616487":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":33,"responsibleParty":96,"collaborators":98,"id":107,"slug":18,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":114,"sex":115,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":18,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":129,"overallStatus":134,"whyStopped":18,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":144},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ALA-PDT Group","EXPERIMENTAL","ALA-PDT administered every 7-14 days for a total of 3-6 sessions.",[13],"Procedure: ALA-PDT",{"label":15,"type":16,"description":17,"interventionNames":18},"Observation Group","NO_INTERVENTION","Observation and follow-up",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","ALA-PDT","Photosensitizer is applied to the cervical canal and cervix, followed by light irradiation, repeated every 7-14 days for 3-6 sessions.",[9],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Xiaoyun Wang, Doctor","CONTACT","+86 0571-87783759","doctorwangxy@zju.edu.cn",{"name":32,"role":28,"phone":18,"phoneExt":18,"email":18},"Jianwei Zhou, Professor",[34,51,60,70,83],{"facility":35,"status":18,"city":36,"state":37,"zip":38,"country":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Women's Hospital School Of Medicine Zhejiang University","Hangzhou","Zhejiang","310000","China",{"type":41,"coordinates":42},"Point",[43,44],120.16142,30.29365,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":18,"email":50},"Ying Li, Doctor","13705815380","17550215@qq.com",{"facility":52,"status":18,"city":36,"state":37,"zip":18,"country":39,"cosmosGeoPoint":53,"geoPoint":55,"contacts":56},"First People's Hospital of Hangzhou",{"type":41,"coordinates":54},[43,44],{"lat":44,"lon":43},[57],{"name":58,"role":28,"phone":59,"phoneExt":18,"email":18},"Hongkai Shang, Doctor","15990032799",{"facility":61,"status":18,"city":36,"state":37,"zip":18,"country":39,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},"Hangzhou Linping District first People's Hospital",{"type":41,"coordinates":63},[43,44],{"lat":44,"lon":43},[66],{"name":67,"role":28,"phone":68,"phoneExt":18,"email":69},"Lifang You, Doctor","18958174527","y20042668@sina.com",{"facility":71,"status":18,"city":72,"state":37,"zip":38,"country":39,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"First Affiliated Hospital of Ningbo University","Ningbo",{"type":41,"coordinates":74},[75,76],121.54945,29.87819,{"lat":76,"lon":75},[79],{"name":80,"role":28,"phone":81,"phoneExt":18,"email":82},"Juanjuan Shi, Doctor","138 8449 6502","bessalice0707@163.com",{"facility":84,"status":18,"city":85,"state":37,"zip":38,"country":39,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Shaoxing People's Hospital","Shaoxing",{"type":41,"coordinates":87},[88,89],120.57864,30.00237,{"lat":89,"lon":88},[92],{"name":93,"role":28,"phone":94,"phoneExt":18,"email":95},"Huaqin Pang","13625757126","hqpang@163.com",{"type":97,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[99,100,101,103,104],{"name":35,"class":6},{"name":52,"class":6},{"name":71,"class":102},"NETWORK",{"name":84,"class":6},{"name":105,"class":106},"Linping First People's Hospital","UNKNOWN","100616487",false,"NCT07306247","Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16\u002F18 Infection","Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical Low-grade Squamous Intraepithelial Lesions With HPV16\u002F18 Infection","PDT for LSIL","Inclusion Criteria:\n\n1. Female, 20-60 years, understands study procedures and consents to participate;\n2. HPV 16 or 18 positive;\n3. Colposcopy-guided cervical biopsy within 3 months showing LSIL;\n4. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Cytology showing ASC-H, HSIL, AGC, or AIS; or evidence of malignant cells on cytology\u002Fhistology, or suspicion of malignancy or invasive cancer;\n2. Colposcopy findings suggestive of invasive cancer or lesion extension to the vaginal wall;\n3. Severe pelvic, cervical, or other gynecological inflammatory conditions identified clinically;\n4. Undiagnosed vaginal bleeding;\n5. Active allergic disease, porphyria, or history of allergy to the study drug or structurally similar agents;\n6. Severe cardiovascular, neurological, psychiatric, endocrine, hepatic, or hematologic disorders; known immunodeficiency; long-term glucocorticoid or immunosuppressant use; active autoimmune disease; or other malignancies;\n7. Pregnant or breastfeeding women;\n8. History of hysterectomy, cervical cancer treatment, or cervical excision\u002Fablation within 6 months (e.g., conization, LEEP, laser);\n9. Use of interferon or antiviral therapy within 3 months;\n10. Any other condition deemed unsuitable for participation by the investigator.",true,"FEMALE","20 Years","60 Years",{"count":119,"type":120},225,"ESTIMATED","INTERVENTIONAL",[123],"NA","This multicenter, prospective trial assesses ALA-PDT versus observation for efficacy and safety in treating cervical LSIL with HPV16\u002F18 infection.",[126,127,128],"HPV-16\u002F18","Photodynamic Therapy (PDT)","LSIL, Low Grade Squamous Intraepithelial Lesion",[130,131,132,133],"cervical low-grade squamous intraepithelial lesions","aminolevulinic acid-mediated photodynamic therapy","efficacy","human papillomavirus","NOT_YET_RECRUITING","2025-12-14",{"date":137,"type":138},"2025-12-29","ACTUAL",{"date":140,"type":120},"2026-01",{"date":142,"type":120},"2027-12",{"name":5,"class":6},5]