[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616488":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":103,"collaborators":105,"id":114,"slug":26,"hasResults":115,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":120,"sex":121,"minAge":122,"maxAge":123,"enrollmentInfo":124,"targetDuration":26,"studyType":127,"phases":128,"briefSummary":130,"conditions":131,"keywords":136,"overallStatus":142,"whyStopped":26,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":152},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ALA-PDT Group","EXPERIMENTAL","ALA-PDT treatment for cervical lesions 6 to 9 times",[13],"Procedure: ALA-PDT",{"label":15,"type":16,"description":17,"interventionNames":18},"LEEP Group","ACTIVE_COMPARATOR","LEEP surgery for cervical lesions",[19],"Procedure: LEEP surgery",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","ALA-PDT","Apply 20% ALA gel for 3 hours, followed by red light irradiation, repeated every 7-14 days for a total of 6-9 sessions.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"LEEP surgery","After anesthesia, cervical iodine staining was performed, followed by LEEP.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Xiaoyun Wang, Doctor","CONTACT","15168479997","doctorwangxy@zju.edu.cn",[38,55,65,76,89],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Women's Hospital School Of Medicine Zhejiang University","Hangzhou","Zhejiang","310000","China",{"type":45,"coordinates":46},"Point",[47,48],120.16142,30.29365,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":53,"phoneExt":26,"email":54},"Ying Li","13705815380","17550215@qq.com",{"facility":56,"status":26,"city":40,"state":41,"zip":26,"country":43,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"First People's Hospital of Hangzhou",{"type":45,"coordinates":58},[47,48],{"lat":48,"lon":47},[61],{"name":62,"role":34,"phone":63,"phoneExt":26,"email":64},"Hongkai Shang, Doctor","15990032799","806520681@qq.com",{"facility":66,"status":26,"city":40,"state":41,"zip":26,"country":43,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},"Hangzhou Linping District first People's Hospital",{"type":45,"coordinates":68},[47,48],{"lat":48,"lon":47},[71,75],{"name":72,"role":34,"phone":73,"phoneExt":26,"email":74},"Lifang You","18958174527","y20042668@sina.com",{"name":26,"role":34,"phone":26,"phoneExt":26,"email":74},{"facility":77,"status":26,"city":78,"state":41,"zip":26,"country":43,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"First Affiliated Hospital of Ningbo University","Ningbo",{"type":45,"coordinates":80},[81,82],121.54945,29.87819,{"lat":82,"lon":81},[85],{"name":86,"role":34,"phone":87,"phoneExt":26,"email":88},"Juanjuan Shi","138 8449 6502","bessalice0707@163.com",{"facility":90,"status":26,"city":91,"state":41,"zip":26,"country":43,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Shaoxing People's Hospital","Shaoxing",{"type":45,"coordinates":93},[94,95],120.57864,30.00237,{"lat":95,"lon":94},[98,102],{"name":99,"role":34,"phone":100,"phoneExt":26,"email":101},"Huaqin Pang","13625757126","hqpang@163.com",{"name":26,"role":34,"phone":26,"phoneExt":26,"email":101},{"type":104,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[106,107,108,110,111],{"name":39,"class":6},{"name":56,"class":6},{"name":77,"class":109},"NETWORK",{"name":90,"class":6},{"name":112,"class":113},"Linping First People's Hospital","UNKNOWN","100616488",false,"NCT07306260","Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL\u002FCIN2","PDT for CIN2","Inclusion Criteria:\n\n1. Female, 25-60 years, understands study procedures and consents to participate;\n2. Colposcopy-guided cervical biopsy within 3 months showing HSIL\u002FCIN2;\n3. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Cytology showing ASC-H, HSIL, AGC, or AIS; or evidence of malignant cells on cytology\u002Fhistology, or suspicion of malignancy or invasive cancer;\n2. Colposcopy findings suggestive of invasive cancer or lesion extension to the vaginal wall;\n3. Severe pelvic, cervical, or other gynecological inflammatory conditions identified clinically;\n4. Undiagnosed vaginal bleeding;\n5. Active allergic disease, porphyria, or history of allergy to the study drug or structurally similar agents;\n6. Severe cardiovascular, neurological, psychiatric, endocrine, hepatic, or hematologic disorders; known immunodeficiency; long-term glucocorticoid or immunosuppressant use; active autoimmune disease; or other malignancies;\n7. Pregnant or breastfeeding women;\n8. History of hysterectomy, cervical cancer treatment, or cervical excision\u002Fablation within 6 months (e.g., conization, LEEP, laser);\n9. Use of interferon or antiviral therapy within 3 months;\n10. Any other condition deemed unsuitable for participation by the investigator.",true,"FEMALE","25 Years","65 Years",{"count":125,"type":126},560,"ESTIMATED","INTERVENTIONAL",[129],"NA","This study evaluates the efficacy and safety of ALA-PDT versus LEEP in treating cervical HSIL\u002FCIN2, aiming to demonstrate non-inferiority in clinical efficacy.",[132,133,134,135],"HSIL, High Grade Squamous Intraepithelial Lesion","CIN 2","HPV (Human Papillomavirus)-Associated","Photodynamic Therapy (PDT)",[137,138,139,140,141],"photodynamic therapy","High Grade Squamous Intraepithelial Lesion","human papillomavirus","loop electrosurgical excision procedure","efficacy","NOT_YET_RECRUITING","2025-12-14",{"date":145,"type":146},"2025-12-29","ACTUAL",{"date":148,"type":126},"2026-01",{"date":150,"type":126},"2027-12",{"name":5,"class":6},5]