[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643475":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":55,"collaborators":26,"id":58,"slug":26,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":26,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":85,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Sisli Hamidiye Etfal Training and Research Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Opioid-Free Anesthesia Group","EXPERIMENTAL","Participants receive an opioid-free anesthesia protocol consisting of dexmedetomidine infusion and ketamine administration during elective retrograde intrarenal surgery (RIRS) performed under laryngeal mask airway (LMA).",[13],"Drug: Dexmedetomidine-Ketamine Opioid-Free Anesthesia",{"label":15,"type":16,"description":17,"interventionNames":18},"Opioid-Based Anesthesia Group","ACTIVE_COMPARATOR","Participants receive conventional fentanyl-based anesthesia during elective retrograde intrarenal surgery (RIRS) performed under laryngeal mask airway (LMA).",[19],"Drug: Fentanyl-Based Anesthesia",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Dexmedetomidine-Ketamine Opioid-Free Anesthesia","Opioid-free anesthesia protocol using dexmedetomidine infusion and ketamine administration without intraoperative opioid use.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Fentanyl-Based Anesthesia","Conventional opioid-based anesthesia protocol using fentanyl during surgery.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"murat sahin","CONTACT","+905070666680","mrtshn52@gmail.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":26},"Omer Faruk Bilin","+905383975966",[41],{"facility":42,"status":26,"city":43,"state":43,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Mus State Hospital","Muş","49100","Turkey (Türkiye)",{"type":47,"coordinates":48},"Point",[49,50],41.48482,38.73163,{"lat":50,"lon":49},[53],{"name":54,"role":34,"phone":35,"phoneExt":26,"email":36},"MURAT SAHIN",{"type":56,"investigatorFullName":33,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Attending Anesthesiologist","100643475",false,"NCT07636070","Multimodal Opioid-Free Anesthesia in RIRS","Multimodal Opioid-Free Anesthesia in RIRS: A Comparison of Dexmedetomidine-Ketamine Combination Versus Conventional Opioid-Based Protocols","Inclusion Criteria:\n\nAged 18 to 65 years ASA physical status I or II ASA III patients with controlled and stable systemic disease (e.g., well-controlled hypertension or type 2 diabetes without end-organ damage) Scheduled for elective retrograde intrarenal surgery (RIRS) under laryngeal mask airway (LMA) Ability to provide written informed consent\n\nExclusion Criteria:\n\nBMI greater than 40 kg\u002Fm² Chronic opioid use Severe cardiovascular disease (uncontrolled arrhythmia, unstable angina, or ejection fraction below 40%) Significant respiratory disease (FEV1 below 60% predicted or oxygen-dependent COPD) Neuropsychiatric disorders Pregnancy Known allergy to any study drug Anticipated difficult airway (Mallampati III-IV, mouth opening less than 3 cm, or thyromental distance less than 6 cm) Requirement for conversion from LMA to endotracheal intubation Emergency cases Withdrawal of informed consent","ALL","18 Years","65 Years",{"count":68,"type":69},60,"ESTIMATED","INTERVENTIONAL",[72],"NA","The goal of this clinical trial is to evaluate whether a dexmedetomidine-ketamine based opioid-free anesthesia (OFA) protocol can provide effective analgesia compared to conventional fentanyl-based anesthesia in adult patients undergoing elective retrograde intrarenal surgery (RIRS). The main questions it aims to answer are:\n\nDoes opioid-free anesthesia reduce postoperative opioid consumption compared to fentanyl-based anesthesia? Does opioid-free anesthesia result in lower postoperative pain scores?\n\nResearchers will compare the dexmedetomidine-ketamine group to the fentanyl-based anesthesia group to see if opioid-free anesthesia reduces opioid requirements and improves recovery quality.\n\nParticipants will receive either a dexmedetomidine-ketamine based OFA protocol or conventional fentanyl-based anesthesia during surgery and will be monitored for pain, opioid consumption, and recovery outcomes postoperatively.",[75,76,77],"Kidney Stone","Retrograde Intrarenal Surgery (RIRS)","Postoperative Pain",[79,80,81,82,83,84],"Opioid-Free Anesthesia","Dexmedetomidine","Ketamine","Postoperative Analgesia","Multimodal Analgesia","Laryngeal Mask Airway","NOT_YET_RECRUITING","2026-06-04",{"date":88,"type":89},"2026-06-09","ACTUAL",{"date":91,"type":69},"2026-06-01",{"date":93,"type":69},"2026-08-10",{"name":33,"class":6},1]