[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576454":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":11,"locations":17,"responsibleParty":107,"collaborators":111,"id":122,"slug":10,"hasResults":123,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":123,"sex":129,"minAge":130,"maxAge":10,"enrollmentInfo":131,"targetDuration":10,"studyType":134,"phases":10,"briefSummary":135,"conditions":136,"keywords":140,"overallStatus":20,"whyStopped":10,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":154},{"fullName":5,"class":6},"Erasmus Medical Center","OTHER",[8],{"label":9,"type":10,"description":9,"interventionNames":10},"Heart failure patients visiting the outpatient clinic",null,[12],{"name":13,"role":14,"phone":15,"phoneExt":10,"email":16},"Isabella Kardys, Prof.","CONTACT","+31650032051","i.kardys@erasmusmc.nl",[18,38,54,65,82,94],{"facility":19,"status":20,"city":21,"state":22,"zip":23,"country":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Noordwest Ziekenhuisgroep","RECRUITING","Alkmaar","North Holland","1815JD","Netherlands",{"type":26,"coordinates":27},"Point",[28,29],4.74861,52.63167,{"lat":29,"lon":28},[32,35],{"name":33,"role":14,"phone":10,"phoneExt":10,"email":34},"Sanneke de Boer, Dr","spm.de.boer@nwz.nl",{"name":36,"role":14,"phone":10,"phoneExt":10,"email":37},"Mylene Loncq de Jong, MD","m.loncqdejong@nwz.nl",{"facility":39,"status":20,"city":40,"state":22,"zip":41,"country":24,"cosmosGeoPoint":42,"geoPoint":46,"contacts":47},"Amsterdam UMC","Amsterdam","1081HV",{"type":26,"coordinates":43},[44,45],4.88969,52.37403,{"lat":45,"lon":44},[48,51],{"name":49,"role":14,"phone":10,"phoneExt":10,"email":50},"Louis L Handoko, Dr.","ml.handoko@amsterdamumc.nl",{"name":52,"role":14,"phone":10,"phoneExt":10,"email":53},"Mylene M 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BSc","s.tiebout@franciscus.nl",{"facility":83,"status":20,"city":67,"state":68,"zip":84,"country":24,"cosmosGeoPoint":85,"geoPoint":87,"contacts":88},"Erasmus MC","3015GD",{"type":26,"coordinates":86},[72,73],{"lat":73,"lon":72},[89,91],{"name":90,"role":14,"phone":15,"phoneExt":10,"email":16},"Isabella Kardys, Professor",{"name":92,"role":14,"phone":10,"phoneExt":10,"email":93},"Jasper Brugts, Professor","j.brugts@erasmusmc.nl",{"facility":95,"status":20,"city":67,"state":68,"zip":96,"country":24,"cosmosGeoPoint":97,"geoPoint":99,"contacts":100},"Ikazia Ziekenhuis","3083AN",{"type":26,"coordinates":98},[72,73],{"lat":73,"lon":72},[101,104],{"name":102,"role":14,"phone":10,"phoneExt":10,"email":103},"Mireille Emans, Dr.","memans@cardiologieopzuid.nl",{"name":105,"role":14,"phone":10,"phoneExt":10,"email":106},"Jose De Mira, MD","j.m.de.mira@ikazia.nl",{"type":108,"investigatorFullName":109,"investigatorTitle":110,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Isabella Kardys","Prof. dr., MD PhD",[112,114,116,119,121],{"name":113,"class":6},"Ikazia Hospital, Rotterdam",{"name":115,"class":6},"Franciscus Gasthuis & Vlietland (Hospital)",{"name":117,"class":118},"OLVG","NETWORK",{"name":120,"class":6},"Universitair Ziekenhuis Brussel",{"name":19,"class":6},"100576454",false,"NCT06785506","Multiple-biomarker Approach for Individualized Treatment of Heart Failure with Preserved Ejection Fraction","A Dynamic, Multiple-biomarker Approach Aiming for Individualized Treatment of Heart Failure with Preserved Ejection Fraction (ADAPT-HFpEF)","ADAPT-HFpEF","Inclusion Criteria:\n\n* Age of 18 years or older\n* Capable of understanding and signing informed consent\n* A diagnosis of HFpEF according to the HFA-PEFF diagnostic algorithm of the ESC or\u002Fand a high (90%) probability of HFpEF according to the H2FPEF score, i.e. a score of 6 or higher.\n\nExclusion Criteria:\n\n* History of LVEF ≤40%\n* Scheduled for surgery or intervention for both coronary and non-coronary indication within 6 months of inclusion\n* Impaired renal function, defined as eGFR \\\u003C 20 mL\u002Fmin\u002F1.73 m2 (CKD-EPI) or requiring dialysis at the time of screening\n* Acute or chronic liver disease, defined by serum levels of transaminases or alkaline phosphatase more than three times the upper limit of normal at screening\n* COPD Gold stage IV\n* Congenital heart disease\n* Pregnancy\n* Coexistent condition with life expectancy of \\\u003C1 year\n* Unlikely to appear at all scheduled follow-up visits\n* Linguistic barrier","ALL","18 Years",{"count":132,"type":133},200,"ESTIMATED","OBSERVATIONAL","The primary objective is to investigate the association between temporal evolutions of blood biomarkers and clinical adverse events, in order to produce a dynamic, individual, and accurate prediction model for patients with HFpEF.\n\nMoreover several secondary objectives will be investigated.",[137,138,139],"Heart Failure with Preserved Ejection Fraction","Heart Failure, Diastolic","Chronic Heart Failure",[141,142,143,144],"HFpEF","Heart failure","preserved ejection fraction","biomarkers","2025-01-20",{"date":147,"type":148},"2025-01-21","ACTUAL",{"date":150,"type":148},"2022-11-25",{"date":152,"type":133},"2026-09-01",{"name":5,"class":6},6]