[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100537503":3},{"organization":4,"outcomesModule":7,"designInfo":73,"detailedDescription":72,"studyPopulation":72,"armGroups":81,"interventions":92,"overallOfficials":98,"centralContacts":103,"locations":108,"responsibleParty":124,"collaborators":72,"id":127,"slug":72,"hasResults":128,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":72,"eligibilityCriteria":132,"healthyVolunteers":128,"sex":133,"minAge":134,"maxAge":72,"enrollmentInfo":135,"targetDuration":72,"studyType":138,"phases":139,"briefSummary":141,"conditions":142,"keywords":72,"overallStatus":145,"whyStopped":72,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":155},{"fullName":5,"class":6},"Nanjing University of Traditional Chinese Medicine","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":31,"otherOutcomes":72},[9,13,16,19,22,25,28],{"measure":10,"description":11,"timeFrame":12},"Respiratory mechanics indicators 1","Oxygenation index(P\u002FF)","Day 0、day 7",{"measure":14,"description":15,"timeFrame":12},"Respiratory mechanics indicators 2","Respiratory rate(RR)",{"measure":17,"description":18,"timeFrame":12},"Respiratory mechanics indicators 3","Driving pressure(DP)",{"measure":20,"description":21,"timeFrame":12},"Respiratory mechanics indicators 4","Positive end expiratory pressure(PEEP)",{"measure":23,"description":24,"timeFrame":12},"Respiratory mechanics indicators 5","Mechanical ventilation days(MV days)",{"measure":26,"description":27,"timeFrame":12},"Respiratory mechanics indicators 6","Mechanical ventilation free days(MV free days)",{"measure":29,"description":30,"timeFrame":12},"Respiratory mechanics indicators 7","Extubation situation",[32,35,38,41,44,47,51,54,57,61,65,69],{"measure":33,"description":34,"timeFrame":12},"Sedation and analgesia","RASS score",{"measure":36,"description":37,"timeFrame":12},"Sedative drug use","The dose and duration of sedative medication will be recorded.",{"measure":39,"description":40,"timeFrame":12},"Analgesic drug use","The dose and duration of analgesic medication will be recorded.",{"measure":42,"description":43,"timeFrame":12},"Inflammatory factors","IL-1β、IL-6、IL-2、IL-4、IL-5、IL-8、IL-10、IL-17、IL-12、 IFN-γ、IFN-α、TNF-α.",{"measure":45,"description":46,"timeFrame":12},"CD4、CD8、CD4\u002FCD8","Flow cytometry will be used to detect serum CD4, CD8 and CD4\u002FCD8 levels.",{"measure":48,"description":49,"timeFrame":50},"Vasoactive drugs applications","The duration of vasoactive drug use will be recorded.","Day 0 to day 7",{"measure":52,"description":53,"timeFrame":50},"CRRT applications","The duration of continuous renal replacement therapy will be recorded.",{"measure":55,"description":56,"timeFrame":50},"ECMO applications","The duration of extracorporeal membrane oxygenation will be recorded.",{"measure":58,"description":59,"timeFrame":60},"All-cause mortality to day 28","The prognosis of patients on the 28th days will be counted.","Up to 28 days",{"measure":62,"description":63,"timeFrame":64},"All-cause mortality to day 60","The prognosis of patients on the 60th days will be counted.","Up to 60 days",{"measure":66,"description":67,"timeFrame":68},"ICU-free days","The prognosis of patients ICU length of stay will be counted.","2 year",{"measure":70,"description":71,"timeFrame":68},"Hospital-free days","The prognosis of patients total length of stay will be counted.",null,{"allocation":74,"interventionModel":75,"interventionModelDescription":72,"primaryPurpose":76,"observationalModel":72,"timePerspective":72,"maskingInfo":77},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":78,"maskingDescription":72,"whoMasked":79},"SINGLE",[80],"INVESTIGATOR",[82,88],{"label":83,"type":84,"description":85,"interventionNames":86},"Experimental group","EXPERIMENTAL","Experimental group: Sterile stainless steel needle electroacupuncture treatment was applied, and the acupuncture points were as follows: bilateral Zusanli (ST36), Neiguan (PC6), Hegu (LI4), Shaoshang (LU11), and Feng Long (ST40). 1 time a day, 30 minutes each time, for 7 days.",[87],"Device: Acupuncture needles",{"label":89,"type":90,"description":91,"interventionNames":72},"Control group","NO_INTERVENTION","Control group: Placebo needles were applied, and the acupuncture points were as follows: bilateral Zusanli (ST36), Neiguan (PC6), Hegu (LI4), Shaoshang (LU11), and Feng Long (ST40). 1 time a day, 30 minutes each time, for 7 days.",[93],{"type":94,"name":95,"description":96,"armGroupLabels":97,"otherNames":72},"DEVICE","Acupuncture needles","1. Experimental group: Sterile stainless steel needle electroacupuncture treatment was applied, and the acupuncture points were as follows: bilateral Zusanli (ST36), Neiguan (PC6), Hegu (LI4), Shaoshang (LU11), and Feng Long (ST40). 1 time a day, 30 minutes each time, for 7 days.\n2. Control group: Placebo needles were applied, and the acupuncture points were as follows: bilateral Zusanli (ST36), Neiguan (PC6), Hegu (LI4), Shaoshang (LU11), and Feng Long (ST40). 1 time a day, 30 minutes each time, for 7 days.",[83],[99],{"name":100,"affiliation":101,"role":102},"Jun Lu, Doctor","Jiangsu Province Hospital of Traditional Chinese Medicine","PRINCIPAL_INVESTIGATOR",[104],{"name":100,"role":105,"phone":106,"phoneExt":72,"email":107},"CONTACT","+86 13813865758","lujun@njucm.edu.cn",[109],{"facility":110,"status":72,"city":111,"state":112,"zip":113,"country":114,"countryCode":115,"cosmosGeoPoint":116,"geoPoint":121,"contacts":122},"Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine","Nanjing","Jiangsu","210029","China","CN",{"type":117,"coordinates":118},"Point",[119,120],118.77778,32.06167,{"lat":120,"lon":119},[123],{"name":100,"role":105,"phone":106,"phoneExt":72,"email":107},{"type":102,"investigatorFullName":125,"investigatorTitle":126,"investigatorAffiliation":5,"oldNameTitle":72,"oldOrganization":72},"Jun Lu, MD","Director","100537503",false,"NCT06278675","Multiple Study of Electroaccpuncture in ARDS","A Multicenter Clinical Study on the Effect of Electroacupuncture on the Mechanical Ventilation Strategy in Patients With Sepsis-related ARDS","Inclusion Criteria:\n\n* Meet the diagnostic criteria of the Surviving Sepsis Campaign: Updated International Guidelines for the Treatment of Sepsis and Septic Shock 2021\n* Meet the diagnostic criteria of the European Society of Critical Care Medicine (ESICM) Guidelines for Acute Respiratory Distress Syndrome: Definition, Phenotype and Respiratory Support Strategies\n* Age \\>18 years\n* Expected duration of mechanical ventilation\\>48 hours\n* Expected ICU stay of more than 7 days\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Participated in other clinical trials\n* Pregnant, lactating or miscarriage\n* Patients with disseminated tumors or tumors receiving chemotherapy and other special treatments\n* Alcohol abuse\n* Severe cardiovascular, brain, liver, kidney, psychiatric diseases, diabetes, multiple system atrophy, cauda equina injury or myelopathy\n* Systolic blood pressure \\\u003C 90mmHg within 2 hours before the start of the study\n* Severe burns or severe skin diseases\n* Pacemaker placement, metal allergy or severe needle sickness\n* Abnormal coagulation function","ALL","18 Years",{"count":136,"type":137},264,"ESTIMATED","INTERVENTIONAL",[140],"NA","In order to clarify the clinical efficacy of electroacupuncture on inhibiting systemic inflammatory response, improving respiratory mechanics parameters and prognosis in patients with sepsis-related ARDS.",[143,144],"Acute Respiratory Distress Syndrome","Sepsis","NOT_YET_RECRUITING","2024-04-22",{"date":148,"type":149},"2024-04-23","ACTUAL",{"date":151,"type":137},"2024-05-10",{"date":153,"type":137},"2026-12-31",{"name":5,"class":6},1]