Health Trials

Multitarget Strategy for Primary Podocytopathies

ConditionNephrotic Syndrome
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

About this trial

The goal of this clinical trial is to verify whether a cell culture system can be used to evaluate the presence of a factor capable of causing proteinuria in the serum of patients with primary podocytopathies. This system will also be used to evaluate the in vitro efficacy of a combined therapy for the treatment of this disorder.

Researchers will compare samples from patients with primary podocytopathies with those obtained from healthy subjects and patients with other renal disorders.

Participants will be asked to visit the clinic at regular intervals for up to 36 months, and to provide blood and urine samples (and a sample of the discarded plasmapheresis effluent in case the procedure is performed).

Eligibility criteria

Qualifiers

Signature of informed consent for study participation

Patients with primary podocytopathies (with a histological diagnosis of FSGS or MCD) showing clinical and/or histological evidence of post-transplant recurrence.

Patients with primary podocytopathies (with a histological diagnosis of FSGS or MCD) without clinical and/or histological evidence of post-transplant recurrence.

Patients with primary podocytopathies in their native kidneys in an active clinical phase of the disease.

Disqualifiers

Subjects affected by primary podocytopathies or other glomerulonephritides in clinical remission or with ESRD (eGFR < 15 ml/min) and/or on renal replacement therapy

Individuals unable to understand and consent to the study procedures

Any clinical condition that, according to the investigator's judgment, could compromise patient safety during study participation

Trial design

Treatments tested in this trial

  • Biologic fluid sampling

Treatment groups

No treatment groups listed

Locations

2
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico20122, Milan Italy
Fondazione IRCCS Policlinico San Matteo Pavia Italy

Sponsors and collaborators

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Lead sponsor

Fondazione Regionale per la Ricerca Biomedica

Collaborator

Source ClinicalTrials.gov