[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100546847":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":39,"responsibleParty":153,"collaborators":155,"id":167,"slug":21,"hasResults":168,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":168,"sex":173,"minAge":174,"maxAge":21,"enrollmentInfo":175,"targetDuration":21,"studyType":178,"phases":179,"briefSummary":181,"conditions":182,"keywords":185,"overallStatus":42,"whyStopped":21,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":199},{"fullName":5,"class":6},"Imperial College London","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with stable angina","EXPERIMENTAL","Patients who:\n\n1. Are symptomatic with angina\n2. Have anatomically severe multi-vessel coronary artery disease\n3. Have physiological evidence of myocardial ischaemia",[13,14],"Procedure: Percutaneous coronary intervention (PCI)","Diagnostic Test: Symptom assessment during experimentally induced ischaemia",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"PROCEDURE","Percutaneous coronary intervention (PCI)","Coronary artery stenting for stable angina",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"DIAGNOSTIC_TEST","Symptom assessment during experimentally induced ischaemia","Transient experimental balloon occlusion across coronary stenosis to determine the symptoms conferred by ischaemia at this stenosis.",[9],[28],{"name":29,"affiliation":5,"role":30},"Rasha Al-Lamee, PhD MRCP","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Shayna Chotai, MBBS 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Trust",{"type":46,"coordinates":97},[86,87],{"lat":87,"lon":86},[100],{"name":101,"role":34,"phone":21,"phoneExt":21,"email":102},"Tushar Kotecha","tushar.kotecha@nhs.net",{"facility":104,"status":42,"city":83,"state":21,"zip":21,"country":44,"cosmosGeoPoint":105,"geoPoint":107,"contacts":108},"St Georges University Hospital",{"type":46,"coordinates":106},[86,87],{"lat":87,"lon":86},[109],{"name":110,"role":34,"phone":21,"phoneExt":21,"email":111},"Rupert Williams","rupertwilliams@nhs.net",{"facility":113,"status":42,"city":114,"state":21,"zip":115,"country":44,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Nottingham City Hospital","Nottingham","NG5 1PB",{"type":46,"coordinates":117},[118,119],-1.15047,52.9536,{"lat":119,"lon":118},[122],{"name":123,"role":34,"phone":124,"phoneExt":21,"email":125},"Andrew Vanezis","0115 969 1169","andrew.vanezis@nhs.net",{"facility":127,"status":128,"city":129,"state":21,"zip":21,"country":44,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Portsmouth Hospitals University NHS Trust","NOT_YET_RECRUITING","Portsmouth",{"type":46,"coordinates":131},[132,133],-1.09125,50.79899,{"lat":133,"lon":132},[136],{"name":137,"role":34,"phone":21,"phoneExt":21,"email":138},"Peter Haworth","peter.haworth@porthosp.nhs.uk",{"facility":140,"status":42,"city":141,"state":21,"zip":142,"country":44,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"University Hospital Southampton","Southampton","SO16 6YD",{"type":46,"coordinates":144},[145,146],-1.40428,50.90395,{"lat":146,"lon":145},[149],{"name":150,"role":34,"phone":151,"phoneExt":21,"email":152},"Nick Curzen","023 8077 7222","nick.curzen@uhs.nhs.uk",{"type":154,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR",[156,159,161,163,165],{"name":157,"class":158},"Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust","OTHER_GOV",{"name":160,"class":6},"Mid and South Essex NHS Foundation Trust",{"name":162,"class":6},"Imperial College Healthcare NHS Trust",{"name":164,"class":6},"St George's Healthcare NHS Trust",{"name":166,"class":6},"Royal Free Hospital NHS Foundation Trust","100546847",false,"NCT06400290","Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina","ORBITA-MOON","Inclusion Criteria:\n\n* Eligibility for PCI due to angina\n* Anatomical evidence of significant multi-vessel coronary stenosis defined by either:\n\n  1. ≥70% stenosis in two or more coronary arteries of ≥2.5mm visual diameter stenosis, on invasive coronary angiography (ICA)\n  2. Severe stenosis in ≥2 coronary arteries of ≥ 2.5mm visual diameter stenosis, on CTCA\n* Physiological evidence of ischaemia with a positive test corresponding to the coronary arteries to be stented, on at least one of the following:\n\n  * dobutamine stress echocardiogram\n  * cardiac MRI\n  * myocardial perfusion study\n  * invasive metrics of coronary physiology\n\nExclusion Criteria:\n\n* Recent acute coronary syndrome\n* Previous coronary artery by-pass graft surgery (CABG)\n* Significant left main stem disease\n* Chronic total occlusion in the target artery(s)\n* Moderate to severe valvular disease\n* Moderate to severe left ventricular impairment\n* Contraindication to PCI or a drug-eluting stents\n* Contraindication to antiplatelet therapy\n* Contraindication to adenosine\n* Pregnant\n* Inability to consent","ALL","18 Years",{"count":176,"type":177},60,"ESTIMATED","INTERVENTIONAL",[180],"NA","ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 60 patients with multi-vessel coronary artery disease.",[183,184],"Stable Angina","Multivessel Coronary Artery Disease",[186,187,188,189],"Angina","Multi-vessel coronary artery disease","Symptoms","Placebo-controlled symptom assessment","2025-06-05",{"date":192,"type":193},"2025-06-06","ACTUAL",{"date":195,"type":193},"2024-06-13",{"date":197,"type":177},"2027-04",{"name":5,"class":6},9]