This prospective study aims to compare functional abnormalities detected using myocardial perfusion SPECT imaging (MPI SPECT) with the extent and severity of anatomical findings on coronary computed tomography angiography (coronary CTA). Additionally, the investigators aim to enhance the diagnostic value of MPI SPECT by quantifying myocardial blood flow and utilizing myocardial flow reserve calculated from dynamic SPECT images.
50 patients with suspected coronary artery disease are anticipated to be enrolled. Pharmacological stress and rest-phase dynamic and static MPI SPECT following an additional coronary CTA scan are to be performed. The obtained multimodality imaging data (functional and anatomical parameters) are planned to be compared and subjected to statistical analysis. The results of this study are expected to improve risk assessment for patients with moderate cardiovascular risk and enhance the diagnostic performance of MPI SPECT.
suspected coronary artery disease
referred to coronary CTA or SPECT MPI by the patient's physician
agrees to the other imaging modality that was not indicated by their physician (coronary CTA or SPECT MPI)
suitable for informed consent
moderate or severe aortic valve stenosis
atrial fibrillation
pregnancy or breastfeeding
history of coronary artery bypass graft implantation
Semmelweis University
Lead sponsor