[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498790":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":27,"studyPopulation":28,"armGroups":29,"interventions":35,"overallOfficials":23,"centralContacts":23,"locations":39,"responsibleParty":66,"collaborators":68,"id":71,"slug":23,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":23,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":23,"studyType":83,"phases":23,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":41,"whyStopped":23,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Istituti Clinici Scientifici Maugeri SpA","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Behavioral performance 1: Decision-making skills","Participants' decision-making performance will be assessed in terms of \"loss aversion\" (i.e., the overweighting of potential losses compared with gains), after removing the potential confounding effect of risk aversion","MRI-acquisition day 1",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Behavioral performance 2: Executive functioning skills","Participants' executive performance will be assessed in terms of well-know metrics such as selective attention and inhibitory control, measured with the Stroop Task and the Stop-Signal-Task, respectively.",{"measure":18,"description":19,"timeFrame":12},"Brain activity underlying decision-making and executive performance","Standard pipelines and pre-processing of fMRI task-related data will be used to detect regional changes of brain activity associated with individual differences in decision-making and executive performance.",{"measure":21,"description":22,"timeFrame":12},"Brain structure related to decision-making and executive performance","Standard pipelines and pre-processing of MRI T1-weighted data will be used to detect patterns of GM volume\u002Fdensity and structural connectivity associated with individual differences in decision-making and executive performance.",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":25,"timePerspective":26,"maskingInfo":23},"COHORT","CROSS_SECTIONAL","The fast growth of Decision Neuroscience is contributing to unveil the cognitive processes underlying choices and their neural bases. The results obtained so far show that decision-making involves neural mechanisms underpinning a complex balance between automatic appetitive or aversive drives generated by subcortical structures, and processes of executive control centered in fronto-parietal brain networks. While the role of meso-limbic structures in reinforcement learning have been widely investigated, it is much less clear to what extent are choices shaped by a) individual differences in executive skills; b) contextual factors potentially interfering with such skills, such as knowing that the outcome of those choices will impact only on one's own vs. another's welfare. This a critical gap, since executive abilities are known to decline even in physiological ageing, thus potentially interfering with the quality of choices. On this ground, this single center non-interventional fMRI study aims to provide novel insights into the relationship between executive and decision-making skills, and their possible changes with ageing, in 150 healthy individuals. This goal will be pursued by combining a behavioral assessment of decision-making and executive skills with a multimodal fMRI session including data concerning a) brain activity associated with decision-making and executive functioning in social vs. non-social contexts, b) brain structural morphometry (grey-matter volume\u002Fdensity), and c) brain structural connectivity (diffusion weighted imaging). The behavioral assessment will involve the main metric of decision-making (e.g., risk aversion, loss aversion, delay discounting) and executive functioning (e.g., selective attention and inhibitory control). MRI data will unveil the neural bases of individual differences in decision-making and executive performance in terms of performance-related patterns of brain activity, structure and connectivity. Results will provide an useful baseline for investigating alterations of decision-making and executive functioning, and of their neural bases, in pathological conditions.","150 healty individuals, aged 18-60 years, sampled from the general population",[30],{"label":31,"type":23,"description":32,"interventionNames":33},"All healthy participants","All healthy participants will undergo behavioral assessment and fMRI",[34],"Other: No intervention",[36],{"type":6,"name":37,"description":37,"armGroupLabels":38,"otherNames":23},"No intervention",[31],[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Pavia","Ita","27100","Italy","IT",{"type":48,"coordinates":49},"Point",[50,51],9.15917,45.19205,{"lat":51,"lon":50},[54,59,63],{"name":55,"role":56,"phone":57,"phoneExt":23,"email":58},"Nicola Canessa, Canessa","CONTACT","+390382375845","nicola.canessa@icsmaugeri.it",{"name":60,"role":56,"phone":61,"phoneExt":23,"email":62},"Tiziana Bachetti","+390382593210","tiziana.bachetti@icsmaugeri.it",{"name":64,"role":65,"phone":23,"phoneExt":23,"email":23},"Nicola Canessa, PhD","PRINCIPAL_INVESTIGATOR",{"type":67,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[69],{"name":70,"class":6},"Istituto Universitario di Studi Superiori Pavia","100498790",false,"NCT05774834","Neural Bases of Decision-making in Healthy Individuals","A Non-interventional Functional Magnetic Resonance Imaging (fMRI) Study on the Neural Bases of Decision-making in Healthy Individuals","Inclusion Criteria:\n\n* Healthy participants, as determined by screening assessments and principal investigator judgment\n* The participant must be able to comply with study requirements as judged by the principal investigator\n\nExclusion Criteria:\n\n* Any history of alcohol and\u002For drug abuse, addiction or suspicion of regular consumption of drugs of abuse\n* Use of any psychoactive medication, or medications known to have effect on central nervous system (CNS) or blood flow\n* Any contraindications for magnetic resonance imaging (MRI) scans or any brain\u002Fhead abnormalities restricting MRI eligibility","ALL","18 Years","60 Years",{"count":81,"type":82},150,"ESTIMATED","OBSERVATIONAL","The goal of this single center non-interventional fMRI study is to assess the neural bases of decision-making and executive functioning in healthy individuals,and whether\u002Fhow their responsiveness is modulated by ageing. The main questions it aims to answer are:\n\n1. are there specific neural correlates for ageing effects on executive functioning (particularly inhibitory control) and decision-making?\n2. Is there a relationship, at the behavioral and neural levels, between ageing-related changes in executive functioning and decision-making?\n\nHealthy participants will be recruited for\n\n1. a behavioral assessment including multiple tests of decision-making and executive functioning\u002Finhibitory control;\n2. a fMRI session to collect data concerning a) brain activity associated with decision-making and executive functioning, b) brain structural morphometriy (grey-matter volume\u002Fdensity), and c) brain structural connectivity (diffusion weighted imaging).\n\nResults will provide an useful baseline for investigating alterations of decision-making and executive functioning, and of their neural bases, in pathological conditions.",[86],"Healthy Volunteers",[88,89,90,91],"decision-making","executive functioning","fMRI","ageing","2026-05-04",{"date":94,"type":95},"2026-05-08","ACTUAL",{"date":97,"type":95},"2018-11-10",{"date":99,"type":82},"2027-10-31",{"name":5,"class":6},1]