Health Trials

About this trial

The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects.

The main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations?

Participants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.

Eligibility criteria

Qualifiers

None

Disqualifiers

No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis

No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment

No self-reported current chronic pain, or acute pain within three months of the study period

No current migraine disorder (i.e., 15 headache days or more in 1 month)

Trial design

Treatments tested in this trial

  • Session A: Positive Placebo + Active tTIS
  • Session B: Positive Placebo + Sham tTIS
  • Session C: Negative Placebo + Active tTIS
  • Session D: Negative Placebo + Sham tTIS
  • Session E: On-Placebo + Sham tTIS
  • Session F: Off-Placebo + Sham tTIS

Treatment groups

196 Participants
are divided into 6 treatment groups

6

Treatment groups

See each treatment group below.

Locations

1
Dartmouth College, Department of Psychological and Brain Sciences03755, HanoverNew Hampshire, United States

Sponsors and collaborators

Trustees of Dartmouth College

Lead sponsor

Source ClinicalTrials.gov