[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100436511":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":75,"collaborators":79,"id":82,"slug":10,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":10,"eligibilityCriteria":87,"healthyVolunteers":83,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":94,"studyType":95,"phases":10,"briefSummary":96,"conditions":97,"keywords":103,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Neuraxial analgesia exposure",null,"For mothers who accept neuraxial labor analgesia, epidural analgesia or combined spinal-epidural analgesia will be provided according to routine practice of each study center.",[13],"Procedure: Neuraxial labor analgesia",{"label":15,"type":10,"description":16,"interventionNames":17},"No neuraxial analgesia exposure","For patients who do not accept neuraxial labor analgesia, analgesics will be prescribed by obstetricians according to routine practice.",[18],"Procedure: No neuraxial labor analgesia",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Neuraxial labor analgesia","Epidural or combined spinal-epidural labor analgesia will be performed according to the routine practice of each study center.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"No neuraxial labor analgesia","Neuraxial analgesia will not be performed. Analgesics will be prescribed by the obstetricians according to routine practice.",[15],[30],{"name":31,"affiliation":5,"role":32},"Dong-Xin Wang, MD,PHD","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","86-13910731903","wangdongxin@hotmail.com",{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},"Ting Ding, MD","86-13718803529","athenading01@hotmail.com",[43,62],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Beijing","Beijing Municipality","100034","China",{"type":50,"coordinates":51},"Point",[52,53],116.39723,39.9075,{"lat":53,"lon":52},[56,59],{"name":57,"role":35,"phone":58,"phoneExt":10,"email":37},"Dong-Xin Wang, MD, PHD","+8610-83572784",{"name":39,"role":35,"phone":60,"phoneExt":10,"email":61},"13718803529","athena_d@sina.com",{"facility":63,"status":44,"city":64,"state":65,"zip":66,"country":48,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Shenzhen Maternity and Child Healthcare Hospital","Shenzhen","Guangdong","518100",{"type":50,"coordinates":68},[69,70],114.0683,22.54554,{"lat":70,"lon":69},[73],{"name":74,"role":35,"phone":10,"phoneExt":10,"email":10},"Yuantao Li, MD",{"type":76,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Dong-Xin Wang","Professor and Chairman, Department of Anesthesiology and Critical Care Medicine",[80],{"name":81,"class":6},"Shenzhen Maternity & Child Healthcare Hospital","100436511",false,"NCT04964206","Neuraxial Labor Analgesia and Offspring Neurodevelopment","Impact of Maternal Neuraxial Labor Analgesia on Offspring Neurodevelopment. A Multicenter, Prospective, Longitudinal Cohort Study","Inclusion Criteria:\n\n1. Primiparae between 18 and 35 years of age with term single cephalic pregnancy;\n2. Undergo regular prenatal examination in the study centers;\n3. Preparing to deliver vaginally.\n\nExclusion Criteria:\n\n1. History of psychiatric diseases (indicate those that are diagnosed before or during pregnancy by psychiatrists);\n2. History of diseases involving the hypothalamic-pituitary-adrenal axis;\n3. Presence of contraindications to epidural analgesia, which includes: (1) History of infectious disease of the central nervous system (poliomyelitis, cerebrospinal meningitis, encephalitis, etc.); (2) History of spinal or intra-spinal disease (trauma or surgery of spinal column, intra-spinal canal mass, etc.); (3) Systemic infection (sepsis); (4) Skin or soft tissue infection at the site of epidural puncture; (5) Coagulopathy.\n4. Presence of contraindications to vaginal delivery;\n5. Other reasons that are considered unsuitable for study participation.","FEMALE","18 Years","35 Years",{"count":92,"type":93},4645,"ESTIMATED","24 Months","OBSERVATIONAL","How perinatal factors affect the long-term development of children has always been an issue of much concern. This study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring neurodevelopment.",[98,99,100,101,102],"Pregnant Women","Labor Pain","Analgesia, Epidural","Infants","Neurodevelopmental Disorders",[104,105,106,101,107],"Pregnant women","Labor pain","Neuraxial labour analgesia","Neurodevelopmental disorders","2026-06-05",{"date":110,"type":111},"2026-06-09","ACTUAL",{"date":113,"type":111},"2022-10-14",{"date":115,"type":93},"2028-12",{"name":77,"class":6},2]