[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490235":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":32,"responsibleParty":48,"collaborators":50,"id":63,"slug":10,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":10,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":10,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Haukeland University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with obsessive-compulsive, social anxiety or panic disorder",null,"Patients with obsessive-compulsive disorder. The MRI substudy will also include patients with social anxiety or panic disorder",[13],"Behavioral: Bergen 4-Day Treatment (B4DT)",{"label":15,"type":10,"description":16,"interventionNames":10},"For MRI substudy: Healthy controls","Healthy controls demographically matched to the patient group on age, sex and years of education",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"BEHAVIORAL","Bergen 4-Day Treatment (B4DT)","A concentrated and exposure-based psychological treatment over four consecutive days",[9],[24],{"name":25,"affiliation":5,"role":26},"Bjarne Hansen, PhD","PRINCIPAL_INVESTIGATOR",[28],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","+4792090765","bjarne.kristian.aaslie.hansen@helse-bergen.no",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Bergen Center for Brain Plasticity","RECRUITING","Bergen","Vestland","5009","Norway",{"type":41,"coordinates":42},"Point",[43,44],5.32415,60.39299,{"lat":44,"lon":43},[47],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[51,53,55,57,59,61],{"name":52,"class":6},"University of Oslo",{"name":54,"class":6},"Amsterdam UMC, location VUmc",{"name":56,"class":6},"University of North Carolina, Chapel Hill",{"name":58,"class":6},"Harvard Medical School (HMS and HSDM)",{"name":60,"class":6},"University of Bergen",{"name":62,"class":6},"Oslo University Hospital","100490235",false,"NCT05663489","Neurobiological Markers of Treatment Response for Anxiety and OCD","Inclusion Criteria:\n\n* Diagnosed with obsessive-compulsive disorder, panic disorder or social anxiety disorder using DSM-5 criteria\n* Referred to National Clinic for 4-Day Treatment, Haukeland University Hospital, Bergen, Norway\n* Consented to participate in the \"Kvalitetsregister for konsentrerte behandlingsformat\"\n\nExclusion Criteria:\n\n* Suicidal, ongoing mania, primary eating disorder, intellectual disability, ongoing psychosis, ongoing substance abuse\n\nFor MRI substudy:\n\nInclusion Criteria:\n\n\\- For the healthy controls, no previous or current psychiatric disorders as detected by the Mini International Neuropsychiatric Interview (MINI)\n\nExclusion Criteria:\n\n\\- MRI incompatibility (e.g. pregnancy, metal implants)",true,"ALL","16 Years",{"count":72,"type":73},500,"ESTIMATED","OBSERVATIONAL","Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided. International guidelines recommend cognitive behavioral therapy (CBT) as the first-line treatment, and research has shown that CBT can be delivered over a concentrated period of time. The Bergen 4-Day Treatment (B4DT) is an exposure-based treatment which is delivered over four consecutive days. B4DT has been shown to induce rapid and long-lasting remission in around 70% of patients. This provides a platform for studying psychological and neurobiological changes associated with treatment response and non-response. The present study will investigate longitudinal changes in psychological measures and DNA methylation in patients who receive the B4DT, as well as a subset will also undergo multimodal brain imaging.",[77,78,79],"Obsessive-Compulsive Disorder","Social Anxiety Disorder","Panic Disorder",[81,82,83],"MRI","epigenetics","genetics","2022-12-15",{"date":86,"type":87},"2022-12-23","ACTUAL",{"date":89,"type":87},"2018-03-23",{"date":91,"type":73},"2027-12-11",{"name":5,"class":6},1]