[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542155":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":17,"locations":25,"responsibleParty":54,"collaborators":57,"id":74,"slug":7,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":7,"maxAge":7,"enrollmentInfo":82,"targetDuration":7,"studyType":85,"phases":7,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":28,"whyStopped":7,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Monash University","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Venepuncture","A single blood draw at the time of presentation to clinic or whilst an inpatient.",[14],{"name":15,"affiliation":5,"role":16},"Prof. Amy Brodtmann, MBBS, FRACP, PhD, FANZAN","PRINCIPAL_INVESTIGATOR",[18,22],{"name":15,"role":19,"phone":20,"phoneExt":7,"email":21},"CONTACT","03 9094 9540","amy.brodtmann@monash.edu",{"name":23,"role":19,"phone":7,"phoneExt":7,"email":24},"Svetlana Ivanic, BSc(Hons)","svetlana.ivanic@monash.edu",[26,42],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Box Hill Hospital","RECRUITING","Box Hill","Victoria","3128","Australia",{"type":34,"coordinates":35},"Point",[36,37],145.12545,-37.81887,{"lat":37,"lon":36},[40],{"name":41,"role":19,"phone":7,"phoneExt":7,"email":24},"Svetlana Ivanic",{"facility":43,"status":28,"city":44,"state":30,"zip":45,"country":32,"cosmosGeoPoint":46,"geoPoint":50,"contacts":51},"Wantirna Health","Wantirna","3152",{"type":34,"coordinates":47},[48,49],145.21667,-37.85,{"lat":49,"lon":48},[52],{"name":53,"role":19,"phone":7,"phoneExt":7,"email":7},"Sarah Shue",{"type":16,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Amy Brodtmann","Professor",[58,60,62,64,66,68,71],{"name":59,"class":6},"Eastern Health",{"name":61,"class":6},"University of Melbourne",{"name":63,"class":6},"Wake Forest University",{"name":65,"class":6},"Deakin University",{"name":67,"class":6},"The Florey Institute of Neuroscience and Mental Health",{"name":69,"class":70},"Invitae Corporation","INDUSTRY",{"name":72,"class":73},"Redenlab","UNKNOWN","100542155",false,"NCT06339190","Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis","A Blood Test for Dementia? A Cohort Study to Assess the Diagnostic Utility of Plasma Neurofilament Light Chain Protein in All-cause Dementia","NAVAIDD","Inclusion Criteria:\n\n* All patients presenting to Eastern Health services with a cognitive complaint or potential neurodegenerative disorder\n\nExclusion Criteria:\n\n* Prognosis \\\u003C12 months\n* No cognitive complaint\n* Patients not involved within the single healthcare network","ALL",{"count":83,"type":84},1000,"ESTIMATED","OBSERVATIONAL","This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests.\n\nParticipants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months.\n\nIndividuals at risk of a Fronto-temporal dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.",[88,89],"Neurodegenerative Diseases","Dementia",[91,89,92,93,94,95,96],"Alzheimer's disease","Neurofilament light chain","Speech","Neurodegeneration","Biomarker","Health care disparity","2025-05-29",{"date":99,"type":100},"2025-05-30","ACTUAL",{"date":102,"type":100},"2021-08-01",{"date":104,"type":84},"2027-12",{"name":5,"class":6},2]