New Heart Imaging Techniques to Evaluate Possible Heart Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-100
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
About this trial
Background:
\- Imaging tests, such as magnetic resonance imaging (MRI), can provide information about heart and blood vessels. The tests let doctors can see the amount of blood vessel narrowing and vessel wall thickness. This information may help diagnose and treat heart disease and other conditions that lead to heart attacks. Better MRI methods are needed to improve heart disease diagnosis, especially by avoiding the use of radiation. Researchers are testing new techniques to improve the quality of heart MRI, compared with more complex studies like catheterization or angiography.
Objectives:
\- To compare heart MRI techniques with other tests used to diagnose heart disease.
Eligibility:
\- People at least 18 years of age who either have or may have heart disease, or are healthy volunteers.
Design:
* Participants will be screened with a physical exam, medical history, and blood tests. * They will have an angiography to study the inside of blood vessels. This test is an x-ray study of the blood vessels. It will be done either separately or as part of a set of tests to diagnose possible heart disease. * Participants will have at least one and up to five MRI scans. The scans will involve different methods of studying the heart and blood vessels. Participants may also have a computed tomography scan to confirm the findings of an MRI scan. * No treatment will be provided as part of this protocol.
Eligibility criteria
Qualifiers
Subjects with or without history of cardiovascular diseases and with various degrees of cardiovascular risk factor. Subjects with known or suspected atherosclerotic disease based on clinical findings or documented by angiography (conventional, CTA or MRA), or Doppler ultrasound. And, healthy volunteers and subjects with known or suspected diseases affecting the thoracic organs, abdominal organs, and other organs affected by metabolic diseases such as body fat and muscles. Subjects at risk for atherosclerosis including: smoking, obesity, hyperlipidemia, low levels of high density lipoproteins (<50 mg/dl for women and <40 mg/dl for men), hypertension, family history (early onset atherosclerosis <55 year old in male and < 65 year old in female who is first degree relative), and diabetes mellitus or metabolic syndrome.
Subject must be willing to participate in the protocol.
Subject age greater than 18 years old.
Subject must be able to provide informed consent.
Disqualifiers
Implanted cardiac pacemaker or defibrillator
Cochlear Implants
Ocular foreign body (e.g. metal shavings)
Embedded shrapnel fragments
Trial design
Treatments tested in this trial
- MR Imaging Techniques - 1
- MR Imaging Techniques - 2
- MR Imaging Techniques - 3
- MR Imaging Techniques - 4
Treatment groups
4,000 Participants
are divided into 4 treatment groupsLocations
1National Institutes of Health Clinical Center20892, BethesdaMaryland, United States
Sponsors and collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Lead sponsor
Source ClinicalTrials.gov