[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100468653":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":29,"responsibleParty":47,"collaborators":10,"id":49,"slug":10,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Banaras Hindu University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Head neck cancer",null,"Histologically diagnosed cases of head and neck cancer",[13],"Other: Next generation Sequencing",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Next generation Sequencing","Next generation sequencing for 161 genes",[9],[20],{"name":21,"affiliation":22,"role":23},"Manoj Pandey, MS, PhD","Professor","PRINCIPAL_INVESTIGATOR",[25],{"name":21,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","9336363640","manojpandey66@gmail.com",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Varanasi","Uttar Pradesh","221005","India",{"type":37,"coordinates":38},"Point",[39,40],83.01041,25.31668,{"lat":40,"lon":39},[43],{"name":44,"role":26,"phone":45,"phoneExt":10,"email":46},"Keshav Murthy, MS","9035424293","keshav.murthy.bmcri@gmail.com",{"type":23,"investigatorFullName":48,"investigatorTitle":22,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Manoj Pandey","100468653",false,"NCT05382585","Newer Therapeutic Targets in Head and Neck Cancers","A Cohort Study to Identify Newer Therapeutic Targets in Head and Neck Cancers","Inclusion Criteria:\n\n* Histologically proven cases of primary head and neck cancers.\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Pregnant and lactating women\n* Multiple cancers or patients with cancer of other sites.","ALL","18 Years","100 Years",{"count":59,"type":60},200,"ESTIMATED","OBSERVATIONAL","Based on the recently identified mutations in HNSCCs, the major pathologic pathways implicated in the tumorigenesis of HNSCC include dysregulation of four processes:\n\n1. cellular survival and proliferation (e.g., TP53, EGFR, MET, and PIK3CA);\n2. cell-cycle control (e.g., CDKN2A and CCND1);\n3. cellular differentiation (e.g., NOTCH1); and\n4. Adhesion and invasion signaling (e.g., FAT1).7 TP53, EGFR, PIK3CA, CDKN2A, CCND1, and MET participate in several common signaling pathways.\n\nAlterations of these genes are most frequently seen in alcohol and tobacco-related HNSCC. However their role in prognostication and selection of therapeutics is not known",[64,65],"Head Neck Cancer","Oral Cancer",[67,68],"Next generation sequencing","predictive biomarker","2024-08-09",{"date":71,"type":72},"2024-08-13","ACTUAL",{"date":74,"type":72},"2017-04-01",{"date":76,"type":60},"2027-12-31",{"name":5,"class":6},1]