[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530144":3},{"organization":4,"outcomesModule":7,"designInfo":407,"detailedDescription":406,"studyPopulation":406,"armGroups":413,"interventions":442,"overallOfficials":456,"centralContacts":461,"locations":469,"responsibleParty":494,"collaborators":406,"id":496,"slug":406,"hasResults":497,"nctId":498,"briefTitle":499,"officialTitle":500,"acronym":501,"eligibilityCriteria":502,"healthyVolunteers":497,"sex":503,"minAge":504,"maxAge":406,"enrollmentInfo":505,"targetDuration":406,"studyType":508,"phases":509,"briefSummary":511,"conditions":512,"keywords":515,"overallStatus":519,"whyStopped":406,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":521,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":529},{"fullName":5,"class":6},"ADIR Association","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":406},[9],{"measure":10,"description":11,"timeFrame":12},"Pulmonary compliance","Comparison of global pulmonary compliance (Cglob) under noninvasive ventilation (NIV) and high-flow oxygen therapy (HFO) during acute respiratory failure in diffuse interstitial pneumonia.","During the intervention, after an exposure of 30 minutes to the oxygen therapy device",[14,16,18,20,22,24,27,29,31,33,35,37,40,42,44,46,48,50,53,55,57,59,61,63,66,68,70,72,74,76,79,81,83,85,87,89,92,94,96,98,100,102,105,107,109,111,113,115,117,120,122,124,126,128,130,133,135,137,139,141,143,146,148,150,152,154,156,159,161,163,165,167,169,172,175,177,179,181,183,185,188,190,192,194,196,198,201,203,205,207,209,211,214,216,218,220,222,224,227,229,231,233,235,237,240,242,244,246,248,250,253,255,257,259,261,263,266,268,270,272,274,276,279,281,283,285,287,289,292,294,296,298,300,302,305,307,309,311,313,315,318,320,322,324,326,328,331,333,335,337,339,341,344,346,348,350,352,354,357,359,361,363,365,367,370,372,374,376,378,380,383,385,387,389,391,393,396,398,400,402,404],{"measure":10,"description":15,"timeFrame":12},"Comparison of global pulmonary compliance (Cglob) under NIV and continuous positive airway pressure (CPAP) during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":10,"description":17,"timeFrame":12},"Comparison of global pulmonary compliance (Cglob) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":10,"description":19,"timeFrame":12},"Comparison of global pulmonary compliance (Cglob) under HFO and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":10,"description":21,"timeFrame":12},"Comparison of global pulmonary compliance (Cglob) under NIV and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":10,"description":23,"timeFrame":12},"Comparison of global pulmonary compliance (Cglob) under CPAP and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":25,"description":26,"timeFrame":12},"Tidal volume","Comparison of Tidal volume under CPAP and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":25,"description":28,"timeFrame":12},"Comparison of Tidal volume under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":25,"description":30,"timeFrame":12},"Comparison of Tidal volume under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":25,"description":32,"timeFrame":12},"Comparison of Tidal volume under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":25,"description":34,"timeFrame":12},"Comparison of Tidal volume under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":25,"description":36,"timeFrame":12},"Comparison of Tidal volume under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":38,"description":39,"timeFrame":12},"end-expiratory lung volume","Comparison of end-expiratory lung volume under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":38,"description":41,"timeFrame":12},"Comparison of end-expiratory lung volume under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":38,"description":43,"timeFrame":12},"Comparison of end-expiratory lung volume under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":38,"description":45,"timeFrame":12},"Comparison of end-expiratory lung volume under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":38,"description":47,"timeFrame":12},"Comparison of end-expiratory lung volume under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":38,"description":49,"timeFrame":12},"Comparison of end-expiratory lung volume under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":51,"description":52,"timeFrame":12},"transpulmonary pressure","Comparison of transpulmonary pressure under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":51,"description":54,"timeFrame":12},"Comparison of transpulmonary pressure under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":51,"description":56,"timeFrame":12},"Comparison of transpulmonary pressure under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":51,"description":58,"timeFrame":12},"Comparison of transpulmonary pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":51,"description":60,"timeFrame":12},"Comparison of transpulmonary pressure under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":51,"description":62,"timeFrame":12},"Comparison of transpulmonary pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":64,"description":65,"timeFrame":12},"driving pressure","Comparison of driving pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":64,"description":67,"timeFrame":12},"Comparison of driving pressure under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":64,"description":69,"timeFrame":12},"Comparison of driving pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":64,"description":71,"timeFrame":12},"Comparison of driving pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":64,"description":73,"timeFrame":12},"Comparison of driving pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":64,"description":75,"timeFrame":12},"Comparison of driving pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":77,"description":78,"timeFrame":12},"Global inhomogeneity index","Comparison of Global inhomogeneity index under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":77,"description":80,"timeFrame":12},"Comparison of Global inhomogeneity index under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":77,"description":82,"timeFrame":12},"Comparison of Global inhomogeneity index under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":77,"description":84,"timeFrame":12},"Comparison of Global inhomogeneity index under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":77,"description":86,"timeFrame":12},"Comparison of Global inhomogeneity index under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":77,"description":88,"timeFrame":12},"Comparison of Global inhomogeneity index under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":90,"description":91,"timeFrame":12},"respiratory rate","Comparison of respiratory rate under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":90,"description":93,"timeFrame":12},"Comparison of respiratory rate under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":90,"description":95,"timeFrame":12},"Comparison of respiratory rate under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":90,"description":97,"timeFrame":12},"Comparison of respiratory rate under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":90,"description":99,"timeFrame":12},"Comparison of respiratory rate under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":90,"description":101,"timeFrame":12},"Comparison of respiratory rate under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":103,"description":104,"timeFrame":12},"inspiratory time","Comparison of inspiratory time under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":103,"description":106,"timeFrame":12},"Comparison of inspiratory time under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":103,"description":108,"timeFrame":12},"Comparison of inspiratory time under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":103,"description":110,"timeFrame":12},"Comparison of inspiratory time under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":103,"description":112,"timeFrame":12},"Comparison of inspiratory time under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":103,"description":114,"timeFrame":12},"Comparison of inspiratory time under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":103,"description":116,"timeFrame":12},"Comparison of inspiratory time under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":118,"description":119,"timeFrame":12},"oesophagal pressure swings","Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":118,"description":121,"timeFrame":12},"Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":118,"description":123,"timeFrame":12},"Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":118,"description":125,"timeFrame":12},"Comparison of oesophagal pressure variations between inspiration and expiration under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":118,"description":127,"timeFrame":12},"Comparison of oesophagal pressure variations between inspiration and expiration under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":118,"description":129,"timeFrame":12},"Comparison of oesophagal pressure variations between inspiration and expiration under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":131,"description":132,"timeFrame":12},"transdiaphragmatic pressure variations","Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":131,"description":134,"timeFrame":12},"Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":131,"description":136,"timeFrame":12},"Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":131,"description":138,"timeFrame":12},"Comparison of transdiaphragmatic pressure variations between inspiration and expiration under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":131,"description":140,"timeFrame":12},"Comparison of transdiaphragmatic pressure variations between inspiration and expiration under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":131,"description":142,"timeFrame":12},"Comparison of transdiaphragmatic pressure variations between inspiration and expiration under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":144,"description":145,"timeFrame":12},"transdiaphragmatic pressure time products","Comparison of transdiaphragmatic pressure time products under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":144,"description":147,"timeFrame":12},"Comparison of transdiaphragmatic pressure time products under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":144,"description":149,"timeFrame":12},"Comparison of transdiaphragmatic pressure time products under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":144,"description":151,"timeFrame":12},"Comparison of transdiaphragmatic pressure time products under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":144,"description":153,"timeFrame":12},"Comparison of transdiaphragmatic pressure time products under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":144,"description":155,"timeFrame":12},"Comparison of transdiaphragmatic pressure time products under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":157,"description":158,"timeFrame":12},"oesophagal pressure time products","Comparison of oesophagal pressure time products under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":157,"description":160,"timeFrame":12},"Comparison of oesophagal pressure time products under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":157,"description":162,"timeFrame":12},"Comparison of oesophagal pressure time products under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":157,"description":164,"timeFrame":12},"Comparison of oesophagal pressure time products under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":157,"description":166,"timeFrame":12},"Comparison of oesophagal pressure time products under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":157,"description":168,"timeFrame":12},"Comparison of oesophagal pressure time products under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":170,"description":171,"timeFrame":12},"ultrasound diaphragmatic strain.","Comparison of ultrasound diaphragmatic strain under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":173,"description":174,"timeFrame":12},"diaphragmatic thickening fraction","Comparison of diaphragmatic thickening fraction under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":173,"description":176,"timeFrame":12},"Comparison of diaphragmatic thickening fraction under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":173,"description":178,"timeFrame":12},"Comparison of diaphragmatic thickening fraction under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":173,"description":180,"timeFrame":12},"Comparison of diaphragmatic thickening fraction under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":173,"description":182,"timeFrame":12},"Comparison of diaphragmatic thickening fraction under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":173,"description":184,"timeFrame":12},"Comparison of diaphragmatic thickening fraction under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":186,"description":187,"timeFrame":12},"peak inspiratory flow","Comparison of peak inspiratory flow under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":186,"description":189,"timeFrame":12},"Comparison of peak inspiratory flow under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":186,"description":191,"timeFrame":12},"Comparison of peak inspiratory flow under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":186,"description":193,"timeFrame":12},"Comparison of peak inspiratory flow under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":186,"description":195,"timeFrame":12},"Comparison of peak inspiratory flow under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":186,"description":197,"timeFrame":12},"Comparison of peak inspiratory flow under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":199,"description":200,"timeFrame":12},"peak expiratory flow","Comparison of peak expiratory flow under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":199,"description":202,"timeFrame":12},"Comparison of peak expiratory flow under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":199,"description":204,"timeFrame":12},"Comparison of peak expiratory flow under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":199,"description":206,"timeFrame":12},"Comparison of peak expiratory flow under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":199,"description":208,"timeFrame":12},"Comparison of peak expiratory flow under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":199,"description":210,"timeFrame":12},"Comparison of peak expiratory flow under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":212,"description":213,"timeFrame":12},"Systolic arterial pressures","Comparison of Systolic arterial pressures under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":212,"description":215,"timeFrame":12},"Comparison of Systolic arterial pressures under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":212,"description":217,"timeFrame":12},"Comparison of Systolic arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":212,"description":219,"timeFrame":12},"Comparison of Systolic arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":212,"description":221,"timeFrame":12},"Comparison of Systolic arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":212,"description":223,"timeFrame":12},"Comparison of Systolic arterial pressures under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":225,"description":226,"timeFrame":12},"Diastolic arterial pressures","Comparison of Diastolic arterial pressures under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":225,"description":228,"timeFrame":12},"Comparison of Diastolic arterial pressures under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":225,"description":230,"timeFrame":12},"Comparison of Diastolic arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":225,"description":232,"timeFrame":12},"Comparison of Diastolic arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":225,"description":234,"timeFrame":12},"Comparison of Diastolic arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":225,"description":236,"timeFrame":12},"Comparison of Diastolic arterial pressures under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":238,"description":239,"timeFrame":12},"Mean arterial pressure","Comparison of Mean arterial pressures under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":238,"description":241,"timeFrame":12},"Comparison of Mean arterial pressures under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":238,"description":243,"timeFrame":12},"Comparison of Mean arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":238,"description":245,"timeFrame":12},"Comparison of Mean arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":238,"description":247,"timeFrame":12},"Comparison of Mean arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":238,"description":249,"timeFrame":12},"Comparison of Mean arterial pressures under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":251,"description":252,"timeFrame":12},"systolic pulmonary arterial pressure","Comparison of systolic pulmonary arterial pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":251,"description":254,"timeFrame":12},"Comparison of systolic pulmonary arterial pressure under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":251,"description":256,"timeFrame":12},"Comparison of systolic pulmonary arterial pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":251,"description":258,"timeFrame":12},"Comparison of systolic pulmonary arterial pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":251,"description":260,"timeFrame":12},"Comparison of systolic pulmonary arterial pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":251,"description":262,"timeFrame":12},"Comparison of systolic pulmonary arterial pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":264,"description":265,"timeFrame":12},"tricuspid annular plane systolic excursion","Comparison of tricuspid annular plane systolic excursion under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":264,"description":267,"timeFrame":12},"Comparison of tricuspid annular plane systolic excursion under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":264,"description":269,"timeFrame":12},"Comparison of tricuspid annular plane systolic excursion under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":264,"description":271,"timeFrame":12},"Comparison of tricuspid annular plane systolic excursion under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":264,"description":273,"timeFrame":12},"Comparison of tricuspid annular plane systolic excursion under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":264,"description":275,"timeFrame":12},"Comparison of tricuspid annular plane systolic excursion under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":277,"description":278,"timeFrame":12},"right ventricular strain","Comparison of right ventricular strain under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":277,"description":280,"timeFrame":12},"Comparison of right ventricular strain under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":277,"description":282,"timeFrame":12},"Comparison of right ventricular strain under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":277,"description":284,"timeFrame":12},"Comparison of right ventricular strain under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":277,"description":286,"timeFrame":12},"Comparison of right ventricular strain under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":277,"description":288,"timeFrame":12},"Comparison of right ventricular strain under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":290,"description":291,"timeFrame":12},"left ventricular ejection fraction","Comparison of left ventricular ejection fraction under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":290,"description":293,"timeFrame":12},"Comparison of left ventricular ejection fraction under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":290,"description":295,"timeFrame":12},"Comparison of left ventricular ejection fraction under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":290,"description":297,"timeFrame":12},"Comparison of left ventricular ejection fraction under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":290,"description":299,"timeFrame":12},"Comparison of left ventricular ejection fraction under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":290,"description":301,"timeFrame":12},"Comparison of left ventricular ejection fraction under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":303,"description":304,"timeFrame":12},"E\u002FE' ratio","Comparison of E\u002FE' ratio under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":303,"description":306,"timeFrame":12},"Comparison of E\u002FE' ratio under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":303,"description":308,"timeFrame":12},"Comparison of E\u002FE' ratio under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":303,"description":310,"timeFrame":12},"Comparison of E\u002FE' ratio under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":303,"description":312,"timeFrame":12},"Comparison of E\u002FE' ratio under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":303,"description":314,"timeFrame":12},"Comparison of E\u002FE' ratio under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":316,"description":317,"timeFrame":12},"right auricular pressure","Comparison of right auricular pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":316,"description":319,"timeFrame":12},"Comparison of right auricular pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":316,"description":321,"timeFrame":12},"Comparison of right auricular pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":316,"description":323,"timeFrame":12},"Comparison of right auricular pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":316,"description":325,"timeFrame":12},"Comparison of right auricular pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":316,"description":327,"timeFrame":12},"Comparison of right auricular pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":329,"description":330,"timeFrame":12},"cardiac output","Comparison of cardiac output under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":329,"description":332,"timeFrame":12},"Comparison of cardiac output under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":329,"description":334,"timeFrame":12},"Comparison of cardiac output under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":329,"description":336,"timeFrame":12},"Comparison of cardiac output under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":329,"description":338,"timeFrame":12},"Comparison of cardiac output under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":329,"description":340,"timeFrame":12},"Comparison of cardiac output under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":342,"description":343,"timeFrame":12},"heart rate","Comparison of heart rate under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":342,"description":345,"timeFrame":12},"Comparison of heart rate under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":342,"description":347,"timeFrame":12},"Comparison of heart rate under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":342,"description":349,"timeFrame":12},"Comparison of heart rate under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":342,"description":351,"timeFrame":12},"Comparison of heart rate under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":342,"description":353,"timeFrame":12},"Comparison of heart rate under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":355,"description":356,"timeFrame":12},"Pulsed oxymetry","Comparison of pulsed oxymetry under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":355,"description":358,"timeFrame":12},"Comparison of pulsed oxymetry under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":355,"description":360,"timeFrame":12},"Comparison of pulsed oxymetry under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":355,"description":362,"timeFrame":12},"Comparison of pulsed oxymetry under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":355,"description":364,"timeFrame":12},"Comparison of pulsed oxymetry under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":355,"description":366,"timeFrame":12},"Comparison of pulsed oxymetry under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":368,"description":369,"timeFrame":12},"transcutaneous carbon dioxide pressure","Comparison of transcutaneous carbon dioxide pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":368,"description":371,"timeFrame":12},"Comparison of transcutaneous carbon dioxide pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":368,"description":373,"timeFrame":12},"Comparison of transcutaneous carbon dioxide pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":368,"description":375,"timeFrame":12},"Comparison of transcutaneous carbon dioxide pressure under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":368,"description":377,"timeFrame":12},"Comparison of transcutaneous carbon dioxide pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":368,"description":379,"timeFrame":12},"Comparison of transcutaneous carbon dioxide pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":381,"description":382,"timeFrame":12},"Dyspnea","Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":381,"description":384,"timeFrame":12},"Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":381,"description":386,"timeFrame":12},"Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":381,"description":388,"timeFrame":12},"Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":381,"description":390,"timeFrame":12},"Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":381,"description":392,"timeFrame":12},"Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":394,"description":395,"timeFrame":12},"Comparison of Comfort","Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":394,"description":397,"timeFrame":12},"Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":394,"description":399,"timeFrame":12},"Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":394,"description":401,"timeFrame":12},"Visual comfort scale (from 0 to 10, 10 is maximal confort) under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":394,"description":403,"timeFrame":12},"Visual comfort scale (from 0 to 10, 10 is maximal confort) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.",{"measure":394,"description":405,"timeFrame":12},"Visual comfort scale (from 0 to 10, 10 is maximal confort) under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.",null,{"allocation":408,"interventionModel":409,"interventionModelDescription":406,"primaryPurpose":410,"observationalModel":406,"timePerspective":406,"maskingInfo":411},"RANDOMIZED","CROSSOVER","TREATMENT",{"masking":412,"maskingDescription":406,"whoMasked":406},"NONE",[414,422,426,430,434,438],{"label":415,"type":416,"description":417,"interventionNames":418},"NIV + CPAP + HFO","EXPERIMENTAL","The patient will be placed under noninvasive mechanical ventilation during 30 min, then continuous positive airway pressure during 30 min and then nasal high-flow oxygen during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.",[419,420,421],"Device: Noninvasive mechanical ventilation","Device: Nasal high-flow oxygen therapy","Device: Continuous positive airway pressure",{"label":423,"type":416,"description":424,"interventionNames":425},"NIV + HFO + CPAP","The patient will be placed under noninvasive mechanical ventilation during 30 min, then nasal high-flow oxygen during 30 min and then continuous positive airway pressure during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.",[419,420,421],{"label":427,"type":416,"description":428,"interventionNames":429},"CPAP + NIV + HFO","The patient will be placed under continuous positive airway pressure during 30 min, then noninvasive mechanical ventilation during 30 min and then nasal high-flow oxygen during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.",[419,420,421],{"label":431,"type":416,"description":432,"interventionNames":433},"CPAP + HFO + NIV","The patient will be placed under continuous positive airway pressure during 30 min, then nasal high-flow oxygen during 30 min and then noninvasive mechanical ventilation during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.",[419,420,421],{"label":435,"type":416,"description":436,"interventionNames":437},"HFO + CPAP + NIV","The patient will be placed under nasal high-flow oxygen during 30 min, then continuous positive airway pressure during 30 min and then noninvasive mechanical ventilation during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.",[419,420,421],{"label":439,"type":416,"description":440,"interventionNames":441},"HFO + NIV + CPAP","The patient will be placed under nasal high-flow oxygen during 30 min, then noninvasive mechanical ventilation during 30 min and then continuous positive airway pressure during 30 min. Each period will be separated by a washout period of maximum 30 min under oxygen with a non-rebreathing mask.",[419,420,421],[443,448,452],{"type":444,"name":445,"description":446,"armGroupLabels":447,"otherNames":406},"DEVICE","Noninvasive mechanical ventilation","Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.",[431,427,435,439,415,423],{"type":444,"name":449,"description":450,"armGroupLabels":451,"otherNames":406},"Nasal high-flow oxygen therapy","Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.",[431,427,435,439,415,423],{"type":444,"name":453,"description":454,"armGroupLabels":455,"otherNames":406},"Continuous positive airway pressure","Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.",[431,427,435,439,415,423],[457],{"name":458,"affiliation":459,"role":460},"Elise ARTAUD-MACARI, MD","University Hospital, Rouen","PRINCIPAL_INVESTIGATOR",[462,466],{"name":458,"role":463,"phone":464,"phoneExt":406,"email":465},"CONTACT","+33232885992","elise.artaud-macari@chu-rouen.fr",{"name":467,"role":463,"phone":464,"phoneExt":406,"email":468},"Maryline LEFORT","mlefort@adir-hautenormandie.com",[470],{"facility":5,"status":406,"city":471,"state":406,"zip":472,"country":473,"countryCode":474,"cosmosGeoPoint":475,"geoPoint":480,"contacts":481},"Rouen","76000","France","FR",{"type":476,"coordinates":477},"Point",[478,479],1.09932,49.44313,{"lat":479,"lon":478},[482,483,486,488,490,492],{"name":458,"role":463,"phone":464,"phoneExt":406,"email":465},{"name":484,"role":485,"phone":406,"phoneExt":406,"email":406},"David DEBEAUMONT, MD","SUB_INVESTIGATOR",{"name":487,"role":485,"phone":406,"phoneExt":406,"email":406},"Christophe GIRAULT, MD",{"name":489,"role":485,"phone":406,"phoneExt":406,"email":406},"Antoine CUVELIER, MD, PHD",{"name":491,"role":485,"phone":406,"phoneExt":406,"email":406},"Pierre Alexandre ROGER, MD",{"name":493,"role":485,"phone":406,"phoneExt":406,"email":406},"Gurvan LEBOUAR, MD",{"type":495,"investigatorFullName":406,"investigatorTitle":406,"investigatorAffiliation":406,"oldNameTitle":406,"oldOrganization":406},"SPONSOR","100530144",false,"NCT06182956","NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases","Evaluation of Physiological Effects of Noninvasive Mechanical Ventilation and High-flow Oxygen Therapy for Acute Exacerbations of Interstitial Lung Diseases","IRAPIDPhysio","Inclusion criteria:\n\n* Age \\> 18 yrs\n* Hospitalization in intensive care unit\n* Acute exacerbation of a previously\u002Fpresently documented diffuse (fibrotic) interstitial lung disease\n* Dyspnea majoration since at least 1 month\n* Alveolar or ground-glass opacities on CT-scan that are superposed to interstitial lung disease and not explained by left heart failure or volume overload\n* Hypoxemia requiring oxygen flows \\> 6 L\u002Fmin\n\nExclusion criteria:\n\n* Contraindication to noninvasive ventilation or high-flow oxygen therapy\n* Immediate indication to endotracheal intubation or hemodynamic assistance\n* Body mass index \\> 40\n* Presence of a pacemaker or an implantable defibrillator\n* Presence of cutaneous lesions where Pulmovista® belt should be placed\n* Moribund patient\n* Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception\n* Protected adult patient (tutorship or curatorship)\n* Patient deprived of liberty by court or administrative decision\n* No possibility to install nasogastric tube\n* Endotracheal or tracheostomy tube requirement during the study\n* Hemodynamic assistance requirement during the study","ALL","18 Years",{"count":506,"type":507},18,"ESTIMATED","INTERVENTIONAL",[510],"NA","The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during acute respiratory failure in diffuse interstitial pneumonia.",[513,514],"Interstitial Lung Disease","Acute Respiratory Failure",[445,449,516,517,518],"Respiratory work","Hemodynamics","Diaphragm","NOT_YET_RECRUITING","2023-12-13",{"date":522,"type":523},"2023-12-27","ACTUAL",{"date":525,"type":507},"2024-01-01",{"date":527,"type":507},"2026-12-31",{"name":5,"class":6},1]