[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598110":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":41,"centralContacts":51,"locations":59,"responsibleParty":82,"collaborators":84,"id":87,"slug":32,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":32,"eligibilityCriteria":91,"healthyVolunteers":88,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":32,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":62,"whyStopped":32,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Chulalongkorn University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Personalized intervention group","EXPERIMENTAL","Participants will receive personalised repetitive transcranial magnetic stimulation mixed reality.",[13],"Device: Personalized rTMS",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard intervention group","ACTIVE_COMPARATOR","Participants will receive standard repetitive transcranial magnetic stimulation plus mixed reality.",[19],"Device: Standard rTMS",{"label":21,"type":22,"description":23,"interventionNames":24},"Sham group","SHAM_COMPARATOR","Participants will receive sham repetitive transcranial magnetic stimulation mixed reality.",[25],"Device: Sham rTMS",[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Personalized rTMS","Personalized repetitive transcranial magnetic stimulation (TMS) together with mixed-reality (MR) exercise",[9],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Standard rTMS","Standard repetitive transcranial magnetic stimulation (TMS) together with mixed-reality (MR) exercise",[15],{"type":28,"name":38,"description":39,"armGroupLabels":40,"otherNames":32},"Sham rTMS","Sham rTMS together with mixed-reality (MR) exercise",[21],[42,45,48],{"name":43,"affiliation":5,"role":44},"Jakkrit Amornvit, MD","PRINCIPAL_INVESTIGATOR",{"name":46,"affiliation":47,"role":44},"Phunsuk Kantha, PT.,PhD","Mahidol University",{"name":49,"affiliation":50,"role":44},"Kulvara Lapanan, PT","Chulalongkorn University and Neuroscience Resesarch Australia",[52,56],{"name":43,"role":53,"phone":54,"phoneExt":32,"email":55},"CONTACT","Thailand: 88-951-9195","jakkrit.a@chula.ac.th",{"name":46,"role":53,"phone":57,"phoneExt":32,"email":58},"Thailand: 93-295-1646","phunsuk.kan@mahidol.ac.th",[60],{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"King Chulalongkorn Memorial hospital, The Thai Red Cross Society","RECRUITING","Bangkok","Pathumwan","10330","Thailand",{"type":68,"coordinates":69},"Point",[70,71],100.50144,13.75398,{"lat":71,"lon":70},[74,76,81],{"name":43,"role":53,"phone":75,"phoneExt":32,"email":55},"+66622169338",{"name":77,"role":53,"phone":78,"phoneExt":79,"email":80},"Phuettha Sangrut, MSc","6622564000","80722","phuettha.s@chulahospital.org",{"name":43,"role":44,"phone":32,"phoneExt":32,"email":32},{"type":83,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[85],{"name":86,"class":6},"King Chulalongkorn Memorial Hospital","100598110",false,"NCT07067229","Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease","Inclusion Criteria:\n\n* Participants aged between 18 and 80 years\n* Diagnosed with any type of motor neuron disease (MND)\n* Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3\n\nExclusion Criteria:\n\n* History of other neurological disorders, such as stroke\n* Use of ventilatory support\n* Severe dementia","ALL","18 Years","80 Years",{"count":96,"type":97},100,"ESTIMATED","INTERVENTIONAL",[100],"NA","Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.",[103],"ALS (Amyotrophic Lateral Sclerosis)",[105,106,107,108],"Amyotrophic Lateral Sclerosis","Transcranial Magnetic Stimulation","Intervention","Augmented Reality","2025-09-21",{"date":111,"type":112},"2025-09-25","ACTUAL",{"date":114,"type":112},"2025-08-01",{"date":116,"type":97},"2027-12-30",{"name":5,"class":6},1]