[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490050":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":57,"centralContacts":63,"locations":70,"responsibleParty":92,"collaborators":94,"id":100,"slug":68,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":101,"sex":107,"minAge":108,"maxAge":68,"enrollmentInfo":109,"targetDuration":68,"studyType":112,"phases":113,"briefSummary":115,"conditions":116,"keywords":122,"overallStatus":73,"whyStopped":68,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"Hebrew SeniorLife","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"tACS(AG) + tDCS(PFC) combo active","EXPERIMENTAL","Participants (Ps) will undergo 20min of daily home-based tACS active + tDCS active intervention over the left angular gyrus and prefrontal cortex for 4 weeks by their trained caregiver\u002Fadministrators (As).",[13],"Device: Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active)",{"label":15,"type":16,"description":17,"interventionNames":18},"tACS(AG) active + tDCS(PFC) sham","ACTIVE_COMPARATOR","Participants (Ps) will undergo 20min of daily home-based tACS active + tDCS sham intervention over the left angular gyrus and prefrontal cortex for 4 weeks by their trained caregiver\u002Fadministrators (As).",[19],"Device: Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham)",{"label":21,"type":16,"description":22,"interventionNames":23},"tACS(AG) sham + tDCS(PFC) active","Participants (Ps) will undergo 20min of daily home-based tACS sham + tDCS active intervention over the left angular gyrus and prefrontal cortex for 4 weeks by their trained caregiver\u002Fadministrators (As).",[24],"Device: Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (active)",{"label":26,"type":27,"description":28,"interventionNames":29},"tACS(AG) sham + tDCS(PFC) sham","SHAM_COMPARATOR","Participants (Ps) will undergo 20min of daily home-based tACS sham + tDCS sham intervention over the left angular gyrus and prefrontal cortex for 4 weeks by their trained caregiver\u002Fadministrators (As).",[30],"Device: Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham)",[32,39,45,51],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"DEVICE","Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active)","Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator to the left angular gyrus and prefrontal cortex.",[9],[38],"Transcranial electrical stimulation (tES)",{"type":33,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham)","A sham transcranial electrical stimulation (tES) will be administered to the participant in their home by their caregiver administrator to the left angular gyrus and prefrontal cortex. It will physically mimic active stimulation.",[26],[44],"Transcranial electrical stimulation (sham condition)",{"type":33,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham)","Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator. Active tACS to the left angular gyrus and sham tDCS to the prefrontal cortex.",[15],[50],"tACS active; tDCS sham",{"type":33,"name":52,"description":53,"armGroupLabels":54,"otherNames":55},"Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (active)","Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator. Sham tACS to the left angular gyrus and active tDCS to the prefrontal cortex.",[21],[56],"tACS sham; tDCS active",[58,61],{"name":59,"affiliation":5,"role":60},"Alvaro Pascual-Leone, MD; PhD","PRINCIPAL_INVESTIGATOR",{"name":62,"affiliation":5,"role":60},"Brad Manor, PhD",[64],{"name":65,"role":66,"phone":67,"phoneExt":68,"email":69},"HomeStim Study","CONTACT","617-971-5416",null,"homestim@hsl.harvard.edu",[71],{"facility":72,"status":73,"city":74,"state":75,"zip":76,"country":77,"cosmosGeoPoint":78,"geoPoint":83,"contacts":84},"Hinda and Arthur Marcus Institute for Aging Research","RECRUITING","Boston","Massachusetts","02131","United States",{"type":79,"coordinates":80},"Point",[81,82],-71.05977,42.35843,{"lat":82,"lon":81},[85,86,88,91],{"name":59,"role":66,"phone":67,"phoneExt":68,"email":69},{"name":87,"role":66,"phone":68,"phoneExt":68,"email":68},"PhD",{"name":89,"role":90,"phone":68,"phoneExt":68,"email":68},"Davide Cappon, PhD","SUB_INVESTIGATOR",{"name":62,"role":60,"phone":68,"phoneExt":68,"email":68},{"type":93,"investigatorFullName":68,"investigatorTitle":68,"investigatorAffiliation":68,"oldNameTitle":68,"oldOrganization":68},"SPONSOR",[95,97],{"name":96,"class":6},"BrightFocus Foundation",{"name":98,"class":99},"National Institute on Aging (NIA)","NIH","100490050",false,"NCT05661084","Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia","Multifocal Transcranial Current Stimulation for Cognitive and Motor Dysfunction in Dementia","ACDCStim","Inclusion Criteria:\n\nParticipants (Ps)\n\n* willing and capable to give informed consent for the participation in the study after it has been thoroughly explained\n* able and willing to comply with all study requirements\n* an informed consent form was signed\n* able to read, write, and communicate in English\n\nCaregiver\u002FAdministrators (As)\n\n* at least 18 years of age\n* able to read, write, and communicate in English\n* self-reported computer proficiency and willingness to learn how to use tES as defined by \"yes\" answers to the questions \"Do you feel comfortable using a computer?\" and \"Are you willing to be the primary caregiver for a participant and learn how to administer tES?\"\n* stated availability during weekdays throughout the study period to administer tES to the Ps\n\nExclusion Criteria:\n\nParticipants (Ps)\n\n* major psychiatric co-morbidity including major depressive disorder, schizophrenia or psychosis\n* blindness or other disabilities that prevent task performance\n* contraindications to tES, as recorded on a standardized screening questionnaire, which include a reported seizure within the past two years, use of neuroactive drugs, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, etc.)\n* the presence of any active dermatological condition, such as eczema, on the scalp a score of 18 or less on the Montreal Cognitive Assessment (MoCA) during the in-person screen\n* an inability to understand study procedures following review of the Informed Consent form\n* Understanding will be assessed by asking the participant to answer the following three questions: 1) What is the purpose of this study? 2) What are the risks of study involvement? 3) If you decide to participate, are you allowed to withdraw from the study at any time? Answers will be recorded by study personnel on the \"Assessment of Protocol Understanding\" form. Insufficient understanding will be defined by one or more incorrect answers, as determined at the discretion of the investigator\n\nCaregiver\u002FAdministrators (As)\n\n* mild cognitive impairment defined by a MoCA score ≤26 during the in-person screen\n* insufficient understanding of study procedures following review of the Informed Consent form\n* Understanding will be assessed by asking the participant to answer the following three questions: 1) What is the purpose of this study? 2) What are the risks of study involvement? 3) If you decide to participate, are you allowed to withdraw from the study at any time? Answers will be recorded by study personnel on the \"Assessment of Protocol Understanding\" form. Insufficient understanding will be defined by one or more incorrect answers, as determined at the discretion of the investigator.\n* poor eyesight, severe arthritis in the hands, pain, deformity or other condition that interferes with successful administration of tES","ALL","55 Years",{"count":110,"type":111},144,"ESTIMATED","INTERVENTIONAL",[114],"NA","This project aims to examine the efficacy of remote, caregiver-led tES\u002Fbrain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild dementia.",[117,118,119,120,121],"Dementia","Memory Loss","Alzheimer Disease","Executive Dysfunction","Mobility Limitation",[123,117,124,125,126,127,128,129],"Alzheimer's Disease","Memory","Brain Stimulation","transcranial alternating current stimulation (tACS)","transcranial direct current stimulation (tDCS)","Executive function","instrumental activities of daily living (IADL)","2026-01-08",{"date":132,"type":133},"2026-01-12","ACTUAL",{"date":135,"type":133},"2023-01-24",{"date":137,"type":111},"2027-08-31",{"name":5,"class":6},1]