[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100392707":3},{"organization":4,"outcomesModule":7,"designInfo":42,"detailedDescription":45,"studyPopulation":46,"armGroups":47,"interventions":53,"overallOfficials":59,"centralContacts":64,"locations":72,"responsibleParty":89,"collaborators":41,"id":92,"slug":41,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":93,"sex":99,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":41,"studyType":105,"phases":41,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":75,"whyStopped":41,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"University Hospital, Bonn","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":41},[9],{"measure":10,"description":11,"timeFrame":12},"Survival","death, liver transplantation","up to 10 years",[14,17,20,23,26,29,32,35,38],{"measure":15,"description":16,"timeFrame":12},"Ascites","Evaluation of amount of ascites according to the Child-Score (0=none;1=moderate\u002Ftreatable; 2=severe\u002Frefractory)",{"measure":18,"description":19,"timeFrame":12},"Hepatic Encephalopathy (HE)","Evaluation of the grade according to the West Haven Criteria (Grade 0 (no HE) - Grade 4 (hepatic coma))",{"measure":21,"description":22,"timeFrame":12},"Variceal Bleeding","Assessment of presence of variceal bleeding",{"measure":24,"description":25,"timeFrame":12},"Liver Failure","defined as Bilirubin level ≥ 12mg\u002Fdl",{"measure":27,"description":28,"timeFrame":12},"Acute-on-Chronic Liver Failure (ACLF)","Presence of ACLF according to the EASL-Chronic liver Failure Consortium (CLIF)-criteria",{"measure":30,"description":31,"timeFrame":12},"Organ Failures","Assessment of Organ failures according to CLIF-Sequential Organ Failure Assessment (SOFA) Score (Score 6 (best) to 18 (worst))",{"measure":33,"description":34,"timeFrame":12},"Kidney Failure","Assessment of AKI according to KDIGO definition",{"measure":36,"description":37,"timeFrame":12},"Sarcopenia","Assessment of sarcopenia according to EASL-guideline definition",{"measure":39,"description":40,"timeFrame":12},"post-surgical survival","Assessment of post-surgical survival",null,{"allocation":41,"interventionModel":41,"interventionModelDescription":41,"primaryPurpose":41,"observationalModel":43,"timePerspective":44,"maskingInfo":41},"COHORT","PROSPECTIVE","NEPTUN consists of liver cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Internal Medicine I, University of Bonn, Germany and receiving a structured routine evaluation and follow up program. The diagnosis of cirrhosis was based on clinical, hemodynamic and biochemical parameters, and ultrasound and\u002For biopsy criteria.","All patients receiving TIPS according to guidelines",[48],{"label":49,"type":41,"description":50,"interventionNames":51},"Prospective","Prospective cohort that received TIPS from 05\u002F12\u002F2020 onwards",[52],"Device: TIPS procedure",[54],{"type":55,"name":56,"description":57,"armGroupLabels":58,"otherNames":41},"DEVICE","TIPS procedure","Implantation of TIPS for portal hypertension",[49],[60],{"name":61,"affiliation":62,"role":63},"Michael Praktiknjo, MD","University of Bonn","PRINCIPAL_INVESTIGATOR",[65,69],{"name":61,"role":66,"phone":67,"phoneExt":41,"email":68},"CONTACT","+49(0)228-287 15770","michael.praktiknjo@ukbonn.de",{"name":70,"role":66,"phone":67,"phoneExt":41,"email":71},"Johannes Chang, MD","johannes.chang@ukbonn.de",[73],{"facility":74,"status":75,"city":76,"state":41,"zip":41,"country":77,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":85},"University Hospital Bonn","RECRUITING","Bonn","Germany","DE",{"type":80,"coordinates":81},"Point",[82,83],7.09549,50.73438,{"lat":83,"lon":82},[86,88],{"name":61,"role":66,"phone":87,"phoneExt":41,"email":68},"+49228 28715770",{"name":70,"role":66,"phone":87,"phoneExt":41,"email":71},{"type":63,"investigatorFullName":90,"investigatorTitle":91,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Michael Praktiknjo","Principal Investigator","100392707",false,"NCT04393519","Non-invasive Evaluation Program for TIPS and Follow Up Network 2 (NEPTUN2)","Non-invasive Evaluation of Prognostic Parameters for Patients With Transjugular Intrahepatic Portosystemic Shunt (TIPS) Using a Structured Follow up Protocol 2","NEPTUN2","Inclusion Criteria:\n\n* Insertion of TIPS according to guidelines\n\nExclusion Criteria:\n\n* Contraindication for TIPS","ALL","18 Years","100 Years",{"count":103,"type":104},1000,"ESTIMATED","OBSERVATIONAL","Evaluation of non-invasive prognostic parameters in patients receiving transjugular intrahepatic portosystemic shunt (TIPS) for complications of portal hypertension. Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.",[108],"Portal Hypertension",[110,111,112,113,114,115,116,117],"transjugular intrahepatic portosystemic shunt (TIPS)","non-invasive assessments","Transthoracic echocardiography (TTE) with Speckle-tracking","Computer tomography scan (CT-scan)","Magnetic resonance imaging (MRI)","Circulating biomarkers","Electroencephalography (EEG)","Elastography","2021-10-04",{"date":120,"type":121},"2021-10-05","ACTUAL",{"date":123,"type":121},"2020-05-12",{"date":125,"type":104},"2030-12-31",{"name":5,"class":6},1]