[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567523":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":31,"locations":41,"responsibleParty":60,"collaborators":25,"id":64,"slug":25,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":25,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":25,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"IRCCS Ospedale San Raffaele","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1","EXPERIMENTAL","AAD therapy",[13],"Drug: Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine)",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2","Re-Do ablation procedure",[18],"Procedure: Re-Do ventricular tachycardia ablation",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Re-Do ventricular tachycardia ablation","1\\. Programmed ventricular stimulation (PVS); 2. Mapping during Sinus Rhythm (SR) or right ventricular pacing in pacing dependent patients; 3. Late Potentials identification; 4. VT(s) induction with diastolic pathway mapping when possible; 5. Catheter Ablation in SR or, at the operator's discretion, in VT if tolerated by the patient; 6. If VT is not inducible or the diastolic pathway is not mappable, a substrate ablation approach will be performed. 7. PVS is repeatedly attempting to reinduce VT after completing; 8. Endpoint: non-inducibility of any VT.",[15],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"DRUG","Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine)","The patients with a positive NIPS already on antiarrhythmic drugs (AAD) before the index procedure will re-start the original antiarrhythmic therapy. Patients who were not on AAD will start a new drug at the operator's discretion (amiodarone, sotalol, or mexiletine) according to clinical practice.",[9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},"Andrea Radinovic, MD","CONTACT","+39 0226436316","radinovic.andrea@hsr.it",{"name":38,"role":34,"phone":39,"phoneExt":25,"email":40},"Anna Montagna, PhD","+39 0226437489","montagna.anna@hsr.it",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":46,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"San Raffaele Hospital, Arrhythmology and Electrophysiology unit","RECRUITING","Milan","Italy","20132",{"type":49,"coordinates":50},"Point",[51,52],9.18951,45.46427,{"lat":52,"lon":51},[55,59],{"name":56,"role":34,"phone":57,"phoneExt":25,"email":58},"Paolo Della Bella, MD","+39 0226436247","dellabella.paolo@hsr.it",{"name":33,"role":34,"phone":25,"phoneExt":25,"email":36},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Dr. Paolo Della Bella","MD","100567523",false,"NCT06669299","Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies","The Value of Late Non-Invasive Programmed Stimulation (NIPS) in the Setting of Ventricular Tachycardia (VT) Ablation to Guide the Subsequent VT Therapeutic Strategies: a Prospective Randomized Multicenter Study","Inclusion Criteria:\n\n* Patients with an implanted ICD (all brands)\n* Patients who underwent a successful (non-inducibility of any VT) Ventricular Tachycardia Ablation procedure, the \"index procedure\", supported by EnSite Precision or CARTO 3D mapping systems for the following etiologies: previous MI, myocarditis, ARVD, IDCM.\n* Induction of monomorphic VT at NIPS 3-7days after a successful index procedure\n* Age 18 years or more\n* Able to provide an informed consent to participate to the study and available to respect the assessments described in the protocol.\n\nExclusion Criteria:\n\n* Inducible VT after index procedure\n* Contraindication to anticoagulants\n* Presence of thrombi\n* Presence of Mitral and Aortic prosthetic valve\n* Recent (\\\u003C3 months) myocardial infarction or unstable angina or Coronary Artery Bypass\n* Pregnant or nursing\n* Ventricular Tachycardia caused by reversible pathology\n* \\\u003C 1 Year life expectancy according to the investigator","ALL","18 Years",{"count":73,"type":74},51,"ESTIMATED","INTERVENTIONAL",[77],"NA","The aim of this study is to define the importance of non-invasive programmed stimulation (NIPS) in risk stratification of ventricular tachycardia (VT) recurrence after catheter ablation and to determine the optimal treatment strategy. The primary objective is to establish whether a new VT ablation based on NIPS inducibility will reduce the risk of VT recurrence compared to antiarrhythmic drug therapy.",[80],"Ventricular Tachycardia (VT)",[82],"Ventricular Tachycardia, VT, Non-Invasive Programmed Stimulation, NIPS, ICD, Implantable Cardioverter Defibrillator","2026-03-24",{"date":85,"type":86},"2026-03-27","ACTUAL",{"date":88,"type":86},"2025-06-12",{"date":90,"type":74},"2027-12",{"name":5,"class":6},1]