Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart Study

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Rouen

About this trial

The investigators hypothesize that the airway pressures generated by High Flow Oxygen Therapy could have a beneficial impact in patients with heart failure, particularly by lowering capillary pulmonary arterial pressures. However, results compared to Non-Invasive Ventilation are difficult to predict due to the lack of data in the literature.

Eligibility criteria

Qualifiers

Major patient

Patient who has undergone cardiac surgery with extracorporeal circulation for more than 24 hours and has been extubated for at least 6 hours.

Pre-operative heart failure with left ventricular ejection fraction < 40%.

Invasive monitoring by pulmonary arterial catheter (Swan-Ganz) with transpulmonary thermodilution and by radial arterial catheter intended for use in the intra- and post-operative monitoring of the patient.

Disqualifiers

Contraindication to the use of NIV or HFO

Patient with orotracheal intubation or tracheotomy

Renal failure with hemodialysis or hemofiltration

Uncontrolled state of shock (PAS<90 mmHg and/or cardiac index<1.8 L/min/m² and/or norepinephrine>0.2 μg/kg/min and/or dobutamine>10 μg/kg/min)

Trial design

Treatments tested in this trial

  • HFO/O2C/NIV
  • NIV/O2C/HFO

Treatment groups

30 Participants
are divided into 2 treatment groups

Locations

1
Chu Rouen76031, Rouen France

Sponsors and collaborators

University Hospital, Rouen

Lead sponsor