[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571838":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":63,"collaborators":65,"id":69,"slug":25,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":25,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":25,"enrollmentInfo":77,"targetDuration":25,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":90,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Medstar Health Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prophylactic ciNPWT","EXPERIMENTAL","Participants in this arm will receive the prophylactic closed incision negative pressure wound therapy (ciNPWT) on one breast following reduction mammaplasty. The ciNPWT will be applied for up to 7 days postoperatively to promote wound healing and prevent complications.",[13],"Device: Prophylactic ciNPWT",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Adhesive Dressing","ACTIVE_COMPARATOR","Participants in this arm will receive the standard adhesive strip dressing (Prineo Ethicon NJ) on the other breast following reduction mammaplasty. The standard dressing will be used as a control to compare postoperative outcomes against the ciNPWT.",[19],"Other: Standard Adhesive Dressing",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","The prophylactic closed incision negative pressure wound therapy (ciNPWT) will be applied to one breast for up to 7 days postoperatively to promote wound healing and prevent complications.",[9],null,{"type":6,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"The standard adhesive strip dressing will be applied to one breast immediately after surgery. It provides a protective covering for the wound during the initial healing phase and is the standard of care for incision management.",[15],[30],{"name":31,"affiliation":32,"role":33},"Kenneth L Fan, MD","MedStar Georgetown University Hospital","PRINCIPAL_INVESTIGATOR",[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Ryan P Lin, MD","CONTACT","2407787804","1","Ryan.Lin@medstar.net",{"name":31,"role":37,"phone":42,"phoneExt":39,"email":43},"(202) 444-8751","kenneth.l.fan@medstar.net",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Medstar Georgetown University Hospital","RECRUITING","Washington D.C.","District of Columbia","20007","United States",{"type":53,"coordinates":54},"Point",[55,56],-77.03637,38.89511,{"lat":56,"lon":55},[59,61,62],{"name":31,"role":37,"phone":60,"phoneExt":25,"email":43},"202-444-8751",{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},{"name":31,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[66],{"name":67,"class":68},"3M","INDUSTRY","100571838",false,"NCT06725459","NPWT Reduction Mammaplasty","Assessing the Application of Closed Incision Negative Pressure Wound Therapy to Reduction Mammaplasty","Inclusion Criteria:\n\n* Female patients\n* Age 18 years or older\n* Scheduled to undergo bilateral reduction mammaplasty with a Wise pattern (anchor) incision and a superomedial, inferior, or central mound pedicle at MedStar Georgetown University Hospital or MedStar Good Samaritan Hospital\n* Able to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\n* Younger than 18 years of age\n* Biologically male patients\n* Scheduled to undergo unilateral breast mammaplasty\n* Currently pregnant or lactating\n* Use of steroids or other immune modulators known to affect wound healing\n* Current smokers who have not paused for a minimum of 4 weeks prior to surgery\n* History of breast cancer\n* History of oncologic or reconstructive breast surgery\n* History of radiation to the breast\n* History of chemotherapy or hormone therapy\n* Tattoos in the area of skin incision\n* Skin conditions known to affect wound healing or scarring of the breast (e.g., cutis laxa)\n* Significant history of scar problems (e.g., hypertrophic scarring or keloids) post-surgical incisions with active bleeding\n* Exposure of blood vessels, organs, bone, or tendon at the base of the reference wound\n* Known allergies to product components (e.g., medical or NPWT tape)\n* Unable to comply with NPWT requirements, including those unable to present for postoperative follow-up\n* Lactating at the time of surgery\n* Require deviation from standard operative or closure techniques (e.g., staples, free nipple grafts)\n* Considered part of a vulnerable population (adults unable to consent, infants, children, teenagers, pregnant women, prisoners)\n* Experience intraoperative complications due to surgical complications not related to the NPWT instrumentation (e.g., expanding hematoma)","FEMALE","18 Years",{"count":78,"type":79},92,"ESTIMATED","INTERVENTIONAL",[82],"NA","In this prospective, randomized, split-body control trial, we aim to compare complications, patient-reported outcomes, and cost differentials following reduction mammaplasty with prophylactic closed incision negative pressure wound therapy versus standard adhesive dressing.",[85,86,87,88,89],"Healthy","Macromastia","Negative Pressure Therapy","Mammaplasty","Wound Healing",[91,92,93,94],"mammaplasty","macromastia","breast reduction","negative pressure therapy","2025-10-24",{"date":97,"type":98},"2025-10-27","ACTUAL",{"date":100,"type":98},"2024-12-17",{"date":102,"type":79},"2026-11-01",{"name":5,"class":6},1]