[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100554767":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":19,"responsibleParty":260,"collaborators":263,"id":285,"slug":7,"hasResults":286,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":7,"eligibilityCriteria":290,"healthyVolunteers":286,"sex":291,"minAge":7,"maxAge":292,"enrollmentInfo":293,"targetDuration":7,"studyType":296,"phases":7,"briefSummary":297,"conditions":298,"keywords":300,"overallStatus":22,"whyStopped":7,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":315},{"fullName":5,"class":6},"Nationwide Children's Hospital","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Anne M Connolly, MD","Nationwide Childrens Hospital","PRINCIPAL_INVESTIGATOR",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Kevin Warf","CONTACT","(614) 355-2765","ReadyCMDLAMA2@nationwidechildrens.org",[20,40,56,73,90,107,124,141,158,175,192,208,225,242],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"University of California, Los Angeles","RECRUITING","Los Angeles","California","90095","United States",{"type":28,"coordinates":29},"Point",[30,31],-118.24368,34.05223,{"lat":31,"lon":30},[34,38],{"name":35,"role":16,"phone":36,"phoneExt":7,"email":37},"Indumathi Mohanchandra","(310) 825-3264","IMohanchandra@mednet.ucla.edu",{"name":39,"role":12,"phone":7,"phoneExt":7,"email":7},"Perry Shieh, MD PhD",{"facility":41,"status":22,"city":42,"state":24,"zip":43,"country":26,"cosmosGeoPoint":44,"geoPoint":48,"contacts":49},"Stanford University","Stanford","94305",{"type":28,"coordinates":45},[46,47],-122.16608,37.42411,{"lat":47,"lon":46},[50,54],{"name":51,"role":16,"phone":52,"phoneExt":7,"email":53},"Lin Karman","(650) 384-9417","lkarman@stanford.edu",{"name":55,"role":12,"phone":7,"phoneExt":7,"email":7},"Carolina Tesi-Rocha, MD",{"facility":57,"status":22,"city":58,"state":59,"zip":60,"country":26,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Ann & Robert H. Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"type":28,"coordinates":62},[63,64],-87.65005,41.85003,{"lat":64,"lon":63},[67,71],{"name":68,"role":16,"phone":69,"phoneExt":7,"email":70},"Raven Hill","(312) 227-2937","rhill@luriechildrens.org",{"name":72,"role":12,"phone":7,"phoneExt":7,"email":7},"Nancy Kuntz, MD",{"facility":74,"status":22,"city":75,"state":76,"zip":77,"country":26,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"University of Iowa Stead Family Children's Hospital","Iowa City","Iowa","52242",{"type":28,"coordinates":79},[80,81],-91.53017,41.66113,{"lat":81,"lon":80},[84,88],{"name":85,"role":16,"phone":86,"phoneExt":7,"email":87},"Laura Knosp","(319) 384-6277","laura-knosp@uiowa.edu",{"name":89,"role":12,"phone":7,"phoneExt":7,"email":7},"Katherine Mathews, MD",{"facility":91,"status":22,"city":92,"state":93,"zip":94,"country":26,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"National Institute of Neurological Disorders and Stroke, NIH","Bethesda","Maryland","20892",{"type":28,"coordinates":96},[97,98],-77.10026,38.98067,{"lat":98,"lon":97},[101,105],{"name":102,"role":16,"phone":103,"phoneExt":7,"email":104},"Dana MacDonald","(301) 402-2273","dana.macdonald@nih.gov",{"name":106,"role":12,"phone":7,"phoneExt":7,"email":7},"Reghan Foley, MD",{"facility":108,"status":22,"city":109,"state":110,"zip":111,"country":26,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Boston Children's Hospital","Boston","Massachusetts","02115",{"type":28,"coordinates":113},[114,115],-71.05977,42.35843,{"lat":115,"lon":114},[118,122],{"name":119,"role":16,"phone":120,"phoneExt":7,"email":121},"Elicia Estrella","(617) 919-7384","Elicia.Estrella@childrens.harvard.edu",{"name":123,"role":12,"phone":7,"phoneExt":7,"email":7},"Partha Ghosh, MD",{"facility":125,"status":22,"city":126,"state":127,"zip":128,"country":26,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"University of Minnesota","Saint Paul","Minnesota","55108",{"type":28,"coordinates":130},[131,132],-93.09327,44.94441,{"lat":132,"lon":131},[135,139],{"name":136,"role":16,"phone":137,"phoneExt":7,"email":138},"Ellen Poppy","(612) 625-2850","poppy005@umn.edu",{"name":140,"role":12,"phone":7,"phoneExt":7,"email":7},"Peter Kang, MD",{"facility":142,"status":22,"city":143,"state":144,"zip":145,"country":26,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"Washington University in St. Louis","St Louis","Missouri","63130",{"type":28,"coordinates":147},[148,149],-90.19789,38.62727,{"lat":149,"lon":148},[152,156],{"name":153,"role":16,"phone":154,"phoneExt":7,"email":155},"Julie Miner","(314) 362-1566","m.julie@wustl.edu",{"name":157,"role":12,"phone":7,"phoneExt":7,"email":7},"Craig Zaidman, MD",{"facility":159,"status":22,"city":160,"state":161,"zip":162,"country":26,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"University of Rochester","Rochester","New York","14627",{"type":28,"coordinates":164},[165,166],-77.61556,43.15478,{"lat":166,"lon":165},[169,173],{"name":170,"role":16,"phone":171,"phoneExt":7,"email":172},"Kim Hart","(585) 275-3767","kim_hart@urmc.rochester.edu",{"name":174,"role":12,"phone":7,"phoneExt":7,"email":7},"Bo Hoon Lee, MD",{"facility":176,"status":22,"city":177,"state":178,"zip":179,"country":26,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"Cincinnati Children's Hospital Medical Center","Cincinnati","Ohio","45229",{"type":28,"coordinates":181},[182,183],-84.51439,39.12711,{"lat":183,"lon":182},[186,190],{"name":187,"role":16,"phone":188,"phoneExt":7,"email":189},"Jessica Getz","(513) 803-9036","Jessica.getz@cchmc.org",{"name":191,"role":12,"phone":7,"phoneExt":7,"email":7},"Cuixia Tian, MD",{"facility":5,"status":22,"city":193,"state":178,"zip":194,"country":26,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"Columbus","43205",{"type":28,"coordinates":196},[197,198],-82.99879,39.96118,{"lat":198,"lon":197},[201,202,203,206],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},{"name":10,"role":12,"phone":7,"phoneExt":7,"email":7},{"name":204,"role":205,"phone":7,"phoneExt":7,"email":7},"Megan Waldrop, MD","SUB_INVESTIGATOR",{"name":207,"role":205,"phone":7,"phoneExt":7,"email":7},"Lindsay Alfano, DPT",{"facility":209,"status":22,"city":210,"state":211,"zip":212,"country":26,"cosmosGeoPoint":213,"geoPoint":217,"contacts":218},"Children's Hospital of Pittsburgh","Pittsburgh","Pennsylvania","15224",{"type":28,"coordinates":214},[215,216],-79.99589,40.44062,{"lat":216,"lon":215},[219,223],{"name":220,"role":16,"phone":221,"phoneExt":7,"email":222},"Heather Dicostanzo","(412) 692-7660","follhl@upmc.edu",{"name":224,"role":12,"phone":7,"phoneExt":7,"email":7},"Hoda Abdel-Hamid, MD",{"facility":226,"status":22,"city":227,"state":228,"zip":229,"country":26,"cosmosGeoPoint":230,"geoPoint":234,"contacts":235},"University of Texas Southwestern","Dallas","Texas","75235",{"type":28,"coordinates":231},[232,233],-96.80667,32.78306,{"lat":233,"lon":232},[236,240],{"name":237,"role":16,"phone":238,"phoneExt":7,"email":239},"Shahera Ranjha","(214) 456-5959","Shahera.Ranjha@UTSouthwestern.edu",{"name":241,"role":12,"phone":7,"phoneExt":7,"email":7},"Kaitlin Batley, MD",{"facility":243,"status":244,"city":245,"state":246,"zip":247,"country":26,"cosmosGeoPoint":248,"geoPoint":252,"contacts":253},"University of Utah","NOT_YET_RECRUITING","Salt Lake City","Utah","84112",{"type":28,"coordinates":249},[250,251],-111.89105,40.76078,{"lat":251,"lon":250},[254,258],{"name":255,"role":16,"phone":256,"phoneExt":7,"email":257},"Jessi Beyer","(801) 587-4865","jessi.beyer@hsc.utah.edu",{"name":259,"role":12,"phone":7,"phoneExt":7,"email":7},"Russell Butterfield, MD PhD",{"type":12,"investigatorFullName":261,"investigatorTitle":262,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Anne M. Connolly","Principle Investigator",[264,267,269,271,273,275,276,277,278,280,282,283,284],{"name":265,"class":266},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH",{"name":268,"class":6},"Ann & Robert H Lurie Children's Hospital of Chicago",{"name":270,"class":6},"Children's Hospital Medical Center, Cincinnati",{"name":272,"class":6},"University of Iowa",{"name":274,"class":6},"Washington University School of Medicine",{"name":41,"class":6},{"name":243,"class":6},{"name":159,"class":6},{"name":279,"class":6},"University of Pittsburgh",{"name":281,"class":6},"University of Texas, Southwestern Medical Center at Dallas",{"name":125,"class":6},{"name":21,"class":6},{"name":108,"class":6},"100554767",false,"NCT06503367","Observation Study in Patients Age 0-5 Years With LAMA2-related Congenital Muscular Dystrophy","Establishing Clinical Trial Readiness for Children 0-5 Years With Congenital Muscular Dystrophy Secondary to LAMA2 Mutations (READY CMD LAMA2)","Inclusion Criteria:\n\n* Signed informed consent by the subject, parent(s) or legally authorized representative (LAR) and\u002For assent by the subject (when applicable).\n* Subject must be aged birth to less than 5.0 years of age at time of consent.\n* A confirmed diagnosis of LAMA2-RD confirmed via:\n\n  a: Two pathogenic variants in the LAMA2 gene (via a CLIA-approved laboratory) or: b. muscle biopsy with absence of merosin (laminin-211) and at least one pathogenic variant in the LAMA2 gene\n* Absence of another confirmed genetic disease.\n* Willingness to maintain current exercise and\u002For physical therapy regimen for the duration of the clinical study.\n* Willingness to comply with the study protocol, including but not limited to, all study procedures and visits.\n\nExclusion Criteria:\n\n* Acute medical illness or hospitalization within 30 days prior to informed consent.\n* Participation in a previous trial of any investigational agent for LAMA2-RD within 1 month prior to informed consent, or use of any other investigational therapy (including off-label use of Losartan) within 30 days prior to informed consent, or participation in other clinical studies, within 30 days (or 3 half-lives, whichever is longer) prior to informed consent, which in the opinion of the PI, may potentially confound results from this study.\n* Other significant medical condition, which in the opinion of the site Principal Investigator may confound interpretation of the clinical course of LAMA2- RD.","ALL","5 Years",{"count":294,"type":295},44,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to understand how young children with LAMA2-related dystrophy move and change over time. We will also learn about how this condition impacts other body systems.\n\nParticipants will undergo:\n\n* Neuromuscular assessments\n* Blood collections\n* Swallowing and breathing assessments\n* Questionnaires",[299],"LAMA2-MD \\(Merosin Deficient Congenital Muscular Dystrophy, MDC1A\\)",[301,302,303,304,305],"Early Phase 1","Observational","Natural History","Neuromuscular","Functional Assessments","2026-04-06",{"date":308,"type":309},"2026-04-08","ACTUAL",{"date":311,"type":309},"2025-05-12",{"date":313,"type":295},"2028-09",{"name":5,"class":6},14]