[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627941":3},{"organization":4,"outcomesModule":7,"designInfo":15,"detailedDescription":11,"studyPopulation":18,"armGroups":19,"interventions":27,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":56,"collaborators":11,"id":58,"slug":11,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":11,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":11,"briefSummary":71,"conditions":72,"keywords":11,"overallStatus":73,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Zhujiang Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9,13],{"measure":10,"description":11,"timeFrame":12},"Gut microbiota composition",null,"baseline",{"measure":14,"description":11,"timeFrame":12},"Lactate level",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":16,"timePerspective":17,"maskingInfo":11},"COHORT","PROSPECTIVE","Meet eligibility criteria",[20,24],{"label":21,"type":11,"description":11,"interventionNames":22},"Cirrhosis",[23],"Other: observational study, no intervention",{"label":25,"type":11,"description":11,"interventionNames":26},"Healthy control",[23],[28],{"type":6,"name":29,"description":29,"armGroupLabels":30,"otherNames":11},"observational study, no intervention",[21,25],[32],{"name":33,"affiliation":34,"role":35},"Xiaolong He","Southern Medical University, China","STUDY_DIRECTOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":11,"email":41},"Yi Xu","CONTACT","+86 13364060425","xuyi2410@hotmail.com",[43],{"facility":44,"status":11,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":11},"Zhujiang Hospital of Southern Medical University","Guangzhou","Guangdong","510000","China","CN",{"type":51,"coordinates":52},"Point",[53,54],113.25,23.11667,{"lat":54,"lon":53},{"type":57,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100627941",false,"NCT07455175","Observational Clinical Study on the Association Between Lactate-mediated Gut Microbiota Alterations and Disease Progression in Liver Cirrhosis.","Inclusion Criteria:\n\n\\- 1. Healthy individuals without a history of liver disease or related underlying disorders; or patients diagnosed with liver cirrhosis and its complications based on imaging and\u002For liver biopsy, with a history of chronic liver disease for more than 6 months. Etiologies include chronic hepatitis B virus infection, nonalcoholic fatty liver disease, and alcoholic liver disease, among others.\n\n2\\. Willing to participate in this study and able to provide written informed consent.\n\nExclusion Criteria:\n\n* 1\\. A history of severe organic diseases involving the liver, gastrointestinal tract, kidneys, or other organ systems; malignant tumors; or autoimmune diseases.\n\n  2\\. Patients with acute infection or inflammatory diseases within the past 1 month.\n\n  3\\. Pregnant or breastfeeding women.",true,"ALL","18 Years","80 Years",{"count":68,"type":69},200,"ESTIMATED","OBSERVATIONAL","To investigate the association between lactate-mediated alterations in the gut microbiota and disease progression in patients with liver cirrhosis; and to examine the correlations of lactate levels among serum, fecal, and tissue samples in patients with liver cirrhosis.",[21],"NOT_YET_RECRUITING","2026-03-03",{"date":76,"type":77},"2026-03-06","ACTUAL",{"date":79,"type":69},"2026-04-01",{"date":81,"type":69},"2028-10-01",{"name":5,"class":6},1]