[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100384892":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":22,"centralContacts":26,"locations":35,"responsibleParty":265,"collaborators":10,"id":267,"slug":10,"hasResults":268,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":10,"eligibilityCriteria":272,"healthyVolunteers":268,"sex":273,"minAge":274,"maxAge":10,"enrollmentInfo":275,"targetDuration":10,"studyType":278,"phases":10,"briefSummary":279,"conditions":280,"keywords":284,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":295},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Part 1",null,"Participants will have endometrioid adenocarcinoma histological diagnosis with planned surgical treatment including hysterectomy in combination with SLN biopsy.",{"label":13,"type":10,"description":14,"interventionNames":15},"Part 2","Participants will have undergone surgery and bilateral sentinel lymph node mapping (negative for malignancy)",[16],"Other: Physical exam",[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"Physical exam","Part 2 participants will be prospectively followed clinically for relapse for 30 months from the date of surgery for physical examination at post-ops visits.",[13],[23],{"name":24,"affiliation":5,"role":25},"Nadeem Abu-Rustum, MD","PRINCIPAL_INVESTIGATOR",[27,31],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","212-639-7051","abu-rusn@mskcc.org",{"name":32,"role":28,"phone":33,"phoneExt":10,"email":34},"Mario Leitao, MD","212-639-3987","leitaom@mskcc.org",[36,53,68,78,91,102,114,125,136,148,159,168,179,193,203,216,228,240,252],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Hartford Healthcare Cancer Institute @ Hartford Hospital","RECRUITING","Hartford","Connecticut","06102","United States",{"type":44,"coordinates":45},"Point",[46,47],-72.68509,41.76371,{"lat":47,"lon":46},[50],{"name":51,"role":28,"phone":52,"phoneExt":10,"email":10},"Jonathan Cosin, MD","860-826-1101",{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":42,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"University of Miami (Data Collection Only)","NOT_YET_RECRUITING","Miami","Florida","33136",{"type":44,"coordinates":60},[61,62],-80.19366,25.77427,{"lat":62,"lon":61},[65],{"name":66,"role":28,"phone":67,"phoneExt":10,"email":10},"Brian Clomovitz, MD","305-243-2233",{"facility":69,"status":38,"city":56,"state":57,"zip":70,"country":42,"cosmosGeoPoint":71,"geoPoint":73,"contacts":74},"Miami Cancer Institute Baptist Health South Florida","33143",{"type":44,"coordinates":72},[61,62],{"lat":62,"lon":61},[75],{"name":76,"role":28,"phone":77,"phoneExt":10,"email":10},"John Paul Diaz, MD","786-596-2000",{"facility":79,"status":38,"city":80,"state":57,"zip":81,"country":42,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"ADVENTHEALTH (Data collection only)","Orlando","32804",{"type":44,"coordinates":83},[84,85],-81.37924,28.53834,{"lat":85,"lon":84},[88],{"name":89,"role":28,"phone":90,"phoneExt":10,"email":10},"Robert Holloway, MD","407-303-2422",{"facility":92,"status":93,"city":94,"state":95,"zip":96,"country":42,"cosmosGeoPoint":97,"geoPoint":101,"contacts":10},"Mayo Clinic (Data Collection and Data Analysis)","ACTIVE_NOT_RECRUITING","Rochester","Minnesota","55905",{"type":44,"coordinates":98},[99,100],-92.4699,44.02163,{"lat":100,"lon":99},{"facility":103,"status":38,"city":104,"state":105,"zip":106,"country":42,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Memorial Sloan Kettering Basking Ridge (All protocol activities)","Basking Ridge","New Jersey","07920",{"type":44,"coordinates":108},[109,110],-74.54932,40.70621,{"lat":110,"lon":109},[113],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":10},{"facility":115,"status":38,"city":116,"state":105,"zip":117,"country":42,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Memorial Sloan Kettering Monmouth (All protocol activities)","Middletown","07748",{"type":44,"coordinates":119},[120,121],-74.11709,40.39428,{"lat":121,"lon":120},[124],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":10},{"facility":126,"status":38,"city":127,"state":105,"zip":128,"country":42,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Memorial Sloan Kettering Bergen (All protocol activities)","Montvale","07645",{"type":44,"coordinates":130},[131,132],-74.02292,41.04676,{"lat":132,"lon":131},[135],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":10},{"facility":137,"status":38,"city":138,"state":139,"zip":140,"country":42,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"Memorial Sloan Kettering Commack (All Protocol Activities)","Commack","New York","11725",{"type":44,"coordinates":142},[143,144],-73.29289,40.84288,{"lat":144,"lon":143},[147],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":10},{"facility":149,"status":38,"city":150,"state":139,"zip":151,"country":42,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Memorial Sloan Kettering Westchester (All protocol activities)","Harrison","10604",{"type":44,"coordinates":153},[154,155],-73.71263,40.96899,{"lat":155,"lon":154},[158],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":10},{"facility":5,"status":38,"city":139,"state":139,"zip":160,"country":42,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"10065",{"type":44,"coordinates":162},[163,164],-74.00597,40.71427,{"lat":164,"lon":163},[167],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":10},{"facility":169,"status":38,"city":170,"state":139,"zip":171,"country":42,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"Memorial Sloan Kettering Nassau (All protocol activities)","Rockville Centre","11553",{"type":44,"coordinates":173},[174,175],-73.64124,40.65871,{"lat":175,"lon":174},[178],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":10},{"facility":180,"status":38,"city":181,"state":182,"zip":183,"country":42,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Lehigh Valley Health Network","Allentown","Pennsylvania","18103",{"type":44,"coordinates":185},[186,187],-75.49018,40.60843,{"lat":187,"lon":186},[190],{"name":191,"role":28,"phone":192,"phoneExt":10,"email":10},"Martin Martino, MD","610-402-3650",{"facility":194,"status":195,"city":196,"state":10,"zip":10,"country":197,"cosmosGeoPoint":198,"geoPoint":202,"contacts":10},"Charles University and General University Hospital (Data Collection Only)","TERMINATED","Prague","Czechia",{"type":44,"coordinates":199},[200,201],14.42076,50.08804,{"lat":201,"lon":200},{"facility":204,"status":38,"city":205,"state":10,"zip":10,"country":206,"cosmosGeoPoint":207,"geoPoint":211,"contacts":212},"OSPEDALE MICHELE E PIETRO (Data Collection Only)","Ferrera","Italy",{"type":44,"coordinates":208},[209,210],8.1879,45.86699,{"lat":210,"lon":209},[213],{"name":214,"role":28,"phone":215,"phoneExt":10,"email":10},"Alessandro Buda, MD","0173 290851",{"facility":217,"status":55,"city":218,"state":10,"zip":10,"country":206,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"UNIVERSITY OF MILANO-BICOCCA, ITALY (Data Collection)","Milan",{"type":44,"coordinates":220},[221,222],9.18951,45.46427,{"lat":222,"lon":221},[225],{"name":226,"role":28,"phone":227,"phoneExt":10,"email":10},"Tommaso Grassi, MD","+39 02 6448 6099",{"facility":229,"status":55,"city":230,"state":10,"zip":10,"country":206,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"FONDAZIONE POLICLINICOUNIVERSITARIO A. GEMELLI, ITALY (Data Collection Only)","Roma",{"type":44,"coordinates":232},[233,234],11.10642,44.99364,{"lat":234,"lon":233},[237],{"name":238,"role":28,"phone":239,"phoneExt":10,"email":10},"Giovanni Scambia, MD","39 06 30151",{"facility":241,"status":38,"city":242,"state":10,"zip":10,"country":206,"cosmosGeoPoint":243,"geoPoint":247,"contacts":248},"L'Azienda Sanitaria Universitaria Friuli Centrale","Udine",{"type":44,"coordinates":244},[245,246],13.23715,46.0693,{"lat":246,"lon":245},[249],{"name":250,"role":28,"phone":10,"phoneExt":10,"email":251},"Giuseppe Vizzielli, MD","giuseppe.vizzielli@asufc.sanita.fvg.it",{"facility":253,"status":55,"city":254,"state":10,"zip":10,"country":255,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"OSLO UNIVERSITY HOSPITAL,RIKSHOPITALET (Data Collection Only)","Oslo","Norway",{"type":44,"coordinates":257},[258,259],10.74609,59.91273,{"lat":259,"lon":258},[262],{"name":263,"role":28,"phone":264,"phoneExt":10,"email":10},"Ane Gerda, MD, PhD","+47 22 93 44 46",{"type":266,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100384892",false,"NCT04291612","Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease","SEntinel Lymph Node Endometrial Cancer Trial: A Prospective Multicenter International Single-Arm Observational Trial (SELECT)","Screening Inclusion Criteria:\n\n* ECOG performance status 0-1 or KPS ≥ 70%\n* Age ≥ 18 years\n* Endometrioid adenocarcinoma histologic diagnosis on endometrial biopsy or dilatation and curettage\n* No evidence of extrauterine disease, or suspicious pelvic lymph nodes, or distant metastases, or cervical invasion on pre-operative conventional imaging studies (Pelvic +\u002F- Abdomen CT or MRI or sonogram, or body PET scan) and physical examination (uterine confined by exam and imaging )\n* Suitable candidate for surgery\n* Planned surgical treatment including hysterectomy in combination with SLN biopsy and a bilateral salpingo-oophorectomy\n* No history of second primary cancer (invasive or in situ) within the past 5 years, not including non-melanoma skin cancer\n* Approved and signed informed consent\n* No history of neoadjuvant chemotherapy or radiotherapy for endometrial cancer\n* No history of prior pelvic or abdominal radiotherapy\n\nScreening Exclusion Criteria:\n\n* Extrauterine disease, or gross lymph node involvement, or cervical invasion suspected on pre-operative imaging studies and physical examination (disease not uterine confined clinical stage \\> I)\n* Contraindication for SLN mapping\n* The planned treatment is not surgery, or the surgical treatment does not include hysterectomy in combination with SLN biopsy and a bilateral salpingo-oophorectomy\n\nEligibility Inclusion Criteria\n\nPatients will be classified in the study cohort (part 2; n=182) according to surgical treatment received, final post hysterectomy and staging pathologic report, and planned adjuvant treatment. The inclusion criteria are specified below.\n\nStudy Cohort (n=182)\n\nA patient will be enrolled in the study cohort if all the following criteria are met:\n\n* At surgery, the patient must undergo:\n\n  * Hysterectomy\n  * Bilateral salpingo-oophorectomy, unless already performed (including allowing unilateral salpingo-oophorectomy if unilateral salpingo-oophorectomy already performed)\n  * Bilateral pelvic SLN mapping (bilateral sentinel nodes are negative for malignancy)\n* On the final pathologic report, the patient must have a diagnosis of:\n\n  * Stage I intermediate-risk endometrial endometrioid cancer (Grade 1 or Grade 2 with ≥ 50% myometrial invasion or Grade 3 with \\\u003C50% myometrial invasion, including non-invasive disease)\n  * Negative pelvic peritoneal cytology\n* Adjuvant treatment as recommended by the multidisciplinary team must be as follows:\n\n  * No adjuvant treatment, or\n  * Intravaginal radiation only\n\nEligibility Exclusion Criteria\n\n* There is intra-operative detection of extra-uterine disease or grossly involved lymph nodes\n* Presence of any positive pelvic nodes including micrometastasis and isolated tumor cells (ITC)\n* Hysterectomy is not performed\n* Bilateral salpingo-oophorectomy is not performed, unless already performed (unilateral salpingo-oophorectomy is allowed if unilateral salpingo-oophorectomy already performed)\n* Failed unilateral or bilateral SLN mapping\n* Patient undergoes a complete unilateral or bilateral pelvic lymphadenectomy\n* Patient undergoes a radical type C hysterectomy\n* Stage IA endometrioid cancer Grade1 or 2 and myometrial invasion \\\u003C50%\n* Stage IB Grade 3 endometrioid cancer\n* Non-endometrioid histology: Serous, clear cell, carcinosarcoma, undifferentiated, or de-differentiated histology noted on final hysterectomy pathology\n* Empty unilateral or bilateral sentinel lymph nodal packet(s)\n* Positive peritoneal cytology","FEMALE","18 Years",{"count":276,"type":277},1715,"ESTIMATED","OBSERVATIONAL","This study is being done to find out how often endometrial cancer recurs after the standard treatment as well as how often the standard treatment results in a lymphedema.",[281,282,283],"Endometrial Cancer","Endometrioid Adenocarcinoma","Endometrial Cancer Stage I",[281,282,285,5],"20-067","2026-03-27",{"date":288,"type":289},"2026-04-01","ACTUAL",{"date":291,"type":289},"2020-02-26",{"date":293,"type":277},"2027-02-26",{"name":5,"class":6},19]