[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599167":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":38,"responsibleParty":49,"collaborators":10,"id":51,"slug":10,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Gruppo Italiano Malattie EMatologiche dell'Adulto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"APL-like",null,"NPM1 AML patients identified as APL-like cohort",[13],"Other: observation of incidence of early vascular events",{"label":15,"type":10,"description":16,"interventionNames":17},"Non APL-like","NPM1 AML patients identified as no APL-like cohort",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"observation of incidence of early vascular events","observation of difference incidence of early vascular events in the two cohorts",[9,15],[24],{"name":25,"affiliation":26,"role":27},"Francesco Mannelli","SOD Ematologia, Università di Firenze, AOU Careggi","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Paola Fazi","CONTACT","0670390528","p.fazi@gimema.it",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":37},"Enrico Crea","0670390514","e.crea@gimema.it",[39],{"facility":26,"status":40,"city":41,"state":10,"zip":10,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":10},"RECRUITING","Florence","Italy",{"type":44,"coordinates":45},"Point",[46,47],11.24626,43.77925,{"lat":47,"lon":46},{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100599167",false,"NCT07080970","Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions","Observational Study on APL-like Subset Within NPM1-mutated Acute Myeloid Leukemia: a Distinct Phenotypic Signature Correlating With Early-onset Vascular Complications. ACTIVATE (APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions)","ACTIVATE","Inclusion Criteria:\n\n* Patients with de novo AML, untreated, newly diagnosed, according to WHO\u002FICC 2022 criteria from January 2015 onwards.\n* Presence of NPM1 mutation.\n* Availability of immunophenotypic characterization at diagnosis\n* Age \\>= 18 years\n* Signed written informed consent according to ICH\u002FEU\u002FGCP and national local laws (if applicable)\n\nExclusion Criteria:\n\n* No specific exclusion criteria are provided once eligibility criteria are met.","ALL","18 Years",{"count":61,"type":62},220,"ESTIMATED","OBSERVATIONAL","This is a multicenter observational study with a retrospective and a prospective cohort investigating clinically and biologically the APL-like subset as a potential predictor of coagulopathy and susceptibility to early vascular events.",[66,67],"Acute Myeloid Leukemia","NPM1 Mutation","2026-06-17",{"date":70,"type":71},"2026-06-22","ACTUAL",{"date":73,"type":62},"2026-07",{"date":75,"type":62},"2028-11",{"name":5,"class":6},1]