[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623379":3},{"organization":4,"outcomesModule":7,"designInfo":37,"detailedDescription":43,"studyPopulation":36,"armGroups":44,"interventions":52,"overallOfficials":36,"centralContacts":61,"locations":68,"responsibleParty":83,"collaborators":36,"id":87,"slug":36,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":36,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":36,"studyType":100,"phases":101,"briefSummary":102,"conditions":103,"keywords":36,"overallStatus":105,"whyStopped":36,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Aalborg University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":36},[9],{"measure":10,"description":11,"timeFrame":12},"Measuring pain by computerized Visual Analog Scale Scoring","We will ask the subjects to rate the sensation of pain on a 100","Immediately after the intervention",[14,18,21,24,27,30,33],{"measure":15,"description":16,"timeFrame":17},"Pain Catastrophizing Scale (PCS).","The PCS assesses negative and exaggerated coping concerning anticipated or experienced painful stimuli. Thirteen items have to be answered on a 5-point Likert-type scale ranging from 0 (Not at all) to 4 (all the time).","Baseline",{"measure":19,"description":20,"timeFrame":17},"Learned Helplessness Scale (LHS)","The questionnaire consists of 20 items, and the participant's response to each item is rated on a 4-point Likert scale branging from strongly agree (1) to strongly disagree (4).",{"measure":22,"description":23,"timeFrame":17},"Depression, Anxiety, Stress Scale (DASS-21)","The questionnaire measures the magnitude of depression, anxiety, and stress. Each of these three subscales consists of 7 questions answered using a 0-3 Likert scale, with 0 meaning \"it did not apply to me\", and 3 meaning \"it applied to me very much\"",{"measure":25,"description":26,"timeFrame":17},"Reinforcement Sensitivity Theory - Personality Questionnaire (RST-PQ).","The RST-PQ contains in total 65 items must be answered on a Response scale: 4-point Likert (Strongly disagree → Strongly agree).",{"measure":28,"description":29,"timeFrame":17},"Positive And Negative Affect Schedule (PANAS)","Twenty words are associated with the subject's current feelings and have to be rated on a 5-points Likert-type scale from: Very slightly or not at all to extremely.",{"measure":31,"description":32,"timeFrame":17},"Difficulties in Emotion Regulation Scale Short Form (DERS-SF)","The questionnaire is an 18-item measure used to identify emotional regulation issues in adults. Participants rate each item on a 5-point Likert scale (from 1 to 5).",{"measure":34,"description":35,"timeFrame":17},"Emotion Regulation Questionnaire (ERQ)","This questionnaire is designed to assess individual differences in the habitual use of two emotion regulation strategies: cognitive reappraisal and expressive suppression. Respondents answer each item on a 7-point Likert-type scale ranging from 1 (strongly disagree) to 7 (strongly agree), where 4 means (neutral).",null,{"allocation":38,"interventionModel":39,"interventionModelDescription":36,"primaryPurpose":40,"observationalModel":36,"timePerspective":36,"maskingInfo":41},"NA","SINGLE_GROUP","BASIC_SCIENCE",{"masking":42,"maskingDescription":36,"whoMasked":36},"NONE","After filling some questionnaires, two areas (4x4 cm, 4 cm apart) will be selected on each forearm of the subjects. The areas will be randomly treated with one of the following trials: hot experimental trial, hot control trial, cold experimental trial, and cold control trial.",[45],{"label":46,"type":47,"description":48,"interventionNames":49},"off-set analgesia","EXPERIMENTAL","The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device. Two protocols will be applied: heat off-set analgesia and cold off-set analgesia.",[50,51],"Other: Heat off-set analgesia","Other: Cold off-set analgesia",[53,57],{"type":6,"name":54,"description":55,"armGroupLabels":56,"otherNames":36},"Heat off-set analgesia","The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device",[46],{"type":6,"name":58,"description":59,"armGroupLabels":60,"otherNames":36},"Cold off-set analgesia","The tests of off-set analgesia will be performed using a TSA2 (Medoc Ltd, Israel) thermal sensory testing device.",[46],[62],{"name":63,"role":64,"phone":65,"phoneExt":66,"email":67},"Silvia Lo Vecchio, PhD","CONTACT","21397785","0045","slv@hst.aau.dk",[69],{"facility":70,"status":36,"city":71,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark","Aalborg","9620","Denmark","DK",{"type":76,"coordinates":77},"Point",[78,79],9.9187,57.048,{"lat":79,"lon":78},[82],{"name":63,"role":64,"phone":65,"phoneExt":66,"email":67},{"type":84,"investigatorFullName":85,"investigatorTitle":86,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"PRINCIPAL_INVESTIGATOR","Silvia Lo Vecchio","Associate Professor","100623379",false,"NCT07395869","Off-set Analgesia Induced by Cold Temperature","Pain and Itch Neuromodulation: Effects of Offset Analgesia, Placebo, and Nocebo and Topographical Distribution of Itch and Pain Receptors","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other drugs\n* Previous or current history of neurological, immunological, musculoskeletal, cardiac disorder or psychiatric diagnoses that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia, etc.)\n* Moles, wounds, scars, or tattoos in the area to be treated or tested\n* Current use of medications that may affect the trial such as antihistamines and pain killers\n* Skin diseases\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain and itch\n* Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies)\n* Contraindications to capsaicin, including intolerance to chili or burns or wounds at the application site (sub-project 4 only)\n* The subject is assessed as unable to engage in the necessary cooperation required by the study",true,"ALL","18 Years","60 Years",{"count":98,"type":99},30,"ESTIMATED","INTERVENTIONAL",[38],"In this study, it will be investigated if the phenomenon of offset analgesia, usually associated with painful heat stimulation, could also be induced using cold painful temperatures.",[104],"Pain","NOT_YET_RECRUITING","2026-02-09",{"date":108,"type":109},"2026-02-11","ACTUAL",{"date":111,"type":99},"2026-02-15",{"date":113,"type":99},"2028-12-31",{"name":5,"class":6},1]