[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641404":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":32,"studyPopulation":32,"armGroups":43,"interventions":59,"overallOfficials":32,"centralContacts":65,"locations":32,"responsibleParty":71,"collaborators":75,"id":81,"slug":32,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":32,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":107,"whyStopped":32,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":32},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":22,"otherOutcomes":32},[9,13,16,19],{"measure":10,"description":11,"timeFrame":12},"Odor Valence Rating","Participant rating of odor pleasantness on a 0-100 mm visual analog scale (e.g., unpleasant → pleasant)","from the baseline visit until the third follow-up visit (about 1 month)",{"measure":14,"description":15,"timeFrame":12},"Late Positive Potential","Mean EEG amplitude (400-800 ms) at centro-parietal sites to olfactory-visual stimuli",{"measure":17,"description":18,"timeFrame":12},"Sniff Volume","Total nasal airflow (in mL) per odor trial, measured via nasal cannula or spirometer",{"measure":20,"description":21,"timeFrame":12},"Corrugator Supercilii EMG Activity","Mean EMG amplitude from facial muscle sensitive to negative affect and aversion",[23,26,29],{"measure":24,"description":25,"timeFrame":12},"Odor Intensity Rating","Participant rating of odor intensity on a 0-100 mm visual analog scale (e.g., not at all → extremely)",{"measure":27,"description":28,"timeFrame":12},"Odor Avoidance Rating","Participant rating of their desire to avoid the odor on a 0-100 mm visual analog scale (e.g., \"not at all\" → \"extreme\")",{"measure":30,"description":31,"timeFrame":12},"Sniff Rate","Breaths per min or per trial window in response to odor exposure",null,{"allocation":34,"interventionModel":35,"interventionModelDescription":32,"primaryPurpose":36,"observationalModel":32,"timePerspective":32,"maskingInfo":37},"RANDOMIZED","CROSSOVER","BASIC_SCIENCE",{"masking":38,"maskingDescription":32,"whoMasked":39},"TRIPLE",[40,41,42],"PARTICIPANT","INVESTIGATOR","OUTCOMES_ASSESSOR",[44,50,54],{"label":45,"type":46,"description":47,"interventionNames":48},"Active tFUS targeting the Amygdala (AMYG)","EXPERIMENTAL","Active tFUS of the bilateral Amygdala randomized at one of the three stimulation visits",[49],"Device: transcranial focused ultrasound (tFUS)",{"label":51,"type":46,"description":52,"interventionNames":53},"Active tFUS targeting the Ventral Striatal Olfactory Tubercle (VSOT)","Active tFUS of the bilateral VSOT randomized at one of the three stimulation visits",[49],{"label":55,"type":56,"description":57,"interventionNames":58},"Sham tFUS","SHAM_COMPARATOR","Sham tFUS randomized at one of three stimulation visits",[49],[60],{"type":61,"name":62,"description":63,"armGroupLabels":64,"otherNames":32},"DEVICE","transcranial focused ultrasound (tFUS)","non-invasive brain stimulation using tFUS",[45,51,55],[66],{"name":67,"role":68,"phone":69,"phoneExt":32,"email":70},"Nicole Cash, Study Coordinator","CONTACT","843-790-3449","cashni@musc.edu",{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Bernadette Cortese","Associate Professor-Faculty",[76,79],{"name":77,"class":78},"National Institute on Deafness and Other Communication Disorders (NIDCD)","NIH",{"name":80,"class":78},"National Institutes of Health (NIH)","100641404",false,"NCT07658365","Olfactory Transcranial Focused Ultrasound","Modulation of Olfactory Valence by Transcranial Focused Ultrasound (tFUS)","O-tFUS","Inclusion Criteria:\n\n* Age 18-65 years\n* Healthy adult volunteers\n* Normal olfactory function (Sniffin' Sticks total TDI ≥ 30.75)\n* Ability to provide informed consent\n* English fluency sufficient for task completion\n\nExclusion Criteria:\n\n* MRI or tFUS contraindications (e.g., metal implants, claustrophobia, pregnancy)\n* Sinonasal conditions affecting airflow or smell\n* Current use of medications that alter olfaction\n* Positive urine drug screen",true,"ALL","18 Years","65 Years",{"count":93,"type":94},28,"ESTIMATED","INTERVENTIONAL",[97],"NA","This study investigates the causal effects of low-intensity transcranial focused ultrasound (tFUS) on odor valence perception and odor-elicited avoidance behaviors in healthy adults. Participants undergo sham and active tFUS targeting the amygdala (AMYG) and ventral striatal olfactory tubercle (VSOT) in a within-subject, randomized, sham-controlled crossover design. Outcomes include subjective odor ratings and objective neurophysiological and behavioral indices of odor valence processing. This research is exploratory and mechanistic in nature and is not intended to evaluate clinical safety or therapeutic efficacy.",[100,101],"Healthy","Olfaction",[103,104,105,106],"healthy volunteer","electroencephalography (EEG)","magnetic resonance imaging (MRI)","odors","NOT_YET_RECRUITING","2026-06-15",{"date":110,"type":111},"2026-06-22","ACTUAL",{"date":113,"type":94},"2026-09-01",{"date":115,"type":94},"2028-04-30",{"name":5,"class":6}]