Optimal Pacing Rate for Cardiac Resynchronization Therapy
ConditionAtrial Fibrillation, Persistent
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-90
SponsorMedstar Health Research Institute
About this trial
This is a prospective, randomized crossover study. The objective of the study is to determine if a pacing rate of 80 beats per minute (bpm) improves exercise tolerance during the 6-minute walk test. The investigators will randomly assign half of the participants to a starting rate of 60 bpm and then switch them to a rate of 80 bpm for 3 months, and vice versa.
Eligibility criteria
Qualifiers
Age 18 years or older
History of persistent or permanent atrial fibrillation
Implantation of CRT or conduction system pacing in prior 3 months to 5 years of study start
History of intrinsic AVN block or have undergone AVN ablation in prior 3 months to 5 years of study start
Disqualifiers
LVEF <50%
Wide QRS (greater than 150ms)
Isolated RV pacing
Severe valvular disease
Trial design
Treatments tested in this trial
- Pacing rate of 80 bpm
- Pacing rate of 60 bpm
Treatment groups
60 Participants
are divided into 2 treatment groupsLocations
5MedStar Georgetown University Hospital20007, Washington D.C.District of Columbia, United States
MedStar Washington Hospital Center20010, Washington D.C.District of Columbia, United States
MedStar Union Memorial Hospital21218, BaltimoreMaryland, United States
MedStar Southern Maryland Hospital20735, ClintonMaryland, United States
Sponsors and collaborators
Medstar Health Research Institute
Lead sponsor
Medtronic
Collaborator
Source ClinicalTrials.gov