[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626520":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":21,"locations":26,"responsibleParty":149,"collaborators":10,"id":151,"slug":10,"hasResults":152,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":152,"sex":157,"minAge":158,"maxAge":10,"enrollmentInfo":159,"targetDuration":10,"studyType":162,"phases":10,"briefSummary":163,"conditions":164,"keywords":167,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":181},{"fullName":5,"class":6},"Azienda ULSS 8 Berica","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with intermediate-high or high-risk pulmonary embolism",null,"Patients with intermediate-high or high-risk pulmonary embolism stratified according to the ESC 2019 guidelines",[13,17],{"name":14,"affiliation":15,"role":16},"Marco Zuin, MD MS","Department of Translational Medicine, University of Ferrara, Italy","STUDY_DIRECTOR",{"name":18,"affiliation":19,"role":20},"Claudio Bilato, MD PhD","Department of Cardiology, Azienda AULSS 8 Berica, Arzignano (Vicenza), Italy","PRINCIPAL_INVESTIGATOR",[22],{"name":18,"role":23,"phone":24,"phoneExt":10,"email":25},"CONTACT","+390444479106","claudio.bilato@aulss8.veneto.it",[27,51,65,84,101,118,133],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"UO Unità di Cure Intensive Cardiologiche e Cardiologia 1, Ospedale Niguarda, Milano","RECRUITING","Milan","Milano","20162","Italy",{"type":35,"coordinates":36},"Point",[37,38],12.59836,42.78235,{"lat":38,"lon":37},[41,45,46,49],{"name":42,"role":23,"phone":43,"phoneExt":10,"email":44},"Claudia Colombo, MD","+390264442565","claudia.colombo@ospealeniguarda.it",{"name":42,"role":20,"phone":10,"phoneExt":10,"email":10},{"name":47,"role":48,"phone":10,"phoneExt":10,"email":10},"Alice Sacco, MD","SUB_INVESTIGATOR",{"name":50,"role":48,"phone":10,"phoneExt":10,"email":10},"Fabrizio Oliva, MD",{"facility":52,"status":29,"city":53,"state":54,"zip":55,"country":33,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"UOC di Cardiologia, Ospedali Riuniti Padova Sud, Monselice, Italia","Monselice","Padova","35043",{"type":35,"coordinates":57},[58,59],11.74984,45.239,{"lat":59,"lon":58},[62],{"name":14,"role":23,"phone":63,"phoneExt":10,"email":64},"+390429715631","marco.zuin@aulss6.veneto.it",{"facility":66,"status":29,"city":67,"state":67,"zip":68,"country":33,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"IRCCS Policlinico San Matteo","Pavia","27100",{"type":35,"coordinates":70},[71,72],9.15917,45.19205,{"lat":72,"lon":71},[75,79,80,82],{"name":76,"role":23,"phone":77,"phoneExt":10,"email":78},"Leonardo De Luca, MD PhD","+390382503158","l.deluca@smatteo.pv.it",{"name":76,"role":20,"phone":10,"phoneExt":10,"email":10},{"name":81,"role":48,"phone":10,"phoneExt":10,"email":10},"Stefano Ghio, MD PhD",{"name":83,"role":48,"phone":10,"phoneExt":10,"email":10},"Guido Tavazzi, MD PhD",{"facility":85,"status":29,"city":86,"state":86,"zip":87,"country":33,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"UO di Sezione di Medicina Interna e Cardiovascolare, Ospedale Santa Maria della Misericordia, Perugia, Italia","Perugia","06129",{"type":35,"coordinates":89},[90,91],12.38878,43.1122,{"lat":91,"lon":90},[94,98,100],{"name":95,"role":23,"phone":96,"phoneExt":10,"email":97},"Cecilia Becattini, MD PhD","+390755786424","cecilia.becattini@unipg.it",{"name":99,"role":48,"phone":10,"phoneExt":10,"email":10},"Maria Cristina Vedovati, MD PhD",{"name":95,"role":20,"phone":10,"phoneExt":10,"email":10},{"facility":102,"status":29,"city":103,"state":103,"zip":104,"country":33,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"UO di Cardiologia 1, Azienda Ospedaliero Universitaria Pisana, Pisa, Italia","Pisa","56126",{"type":35,"coordinates":106},[107,108],10.4036,43.70853,{"lat":108,"lon":107},[111,115,116],{"name":112,"role":23,"phone":113,"phoneExt":10,"email":114},"Rosalinda Madonna, MD PhD","+39050996975","rosalinda.madonna@unipi.it",{"name":112,"role":20,"phone":10,"phoneExt":10,"email":10},{"name":117,"role":48,"phone":10,"phoneExt":10,"email":10},"Raffaele De Caterina, MD PhD",{"facility":119,"status":29,"city":120,"state":120,"zip":121,"country":33,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"UO di Cardiologia, Azienda Ospedaliera Ordine Mauriziano di Torino","Torino","10128",{"type":35,"coordinates":123},[124,125],11.99138,44.88856,{"lat":125,"lon":124},[128,132],{"name":129,"role":23,"phone":130,"phoneExt":10,"email":131},"Giuseppe Musumeci, MD","+390115082515","giuseppe.musumeci@gmail.com",{"name":129,"role":20,"phone":10,"phoneExt":10,"email":10},{"facility":134,"status":29,"city":135,"state":136,"zip":137,"country":33,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"UOC di Cardiologia, Ospedali dell'Ovest Vicentino, Arzignano, IItalia","Arzignano","Vicenza","36071",{"type":35,"coordinates":139},[140,141],11.33446,45.52027,{"lat":141,"lon":140},[144,146,147],{"name":18,"role":23,"phone":145,"phoneExt":10,"email":25},"+390444931163",{"name":18,"role":20,"phone":10,"phoneExt":10,"email":10},{"name":148,"role":48,"phone":10,"phoneExt":10,"email":10},"Chiara Dalla Valle, MD",{"type":150,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100626520",false,"NCT07436702","Optimal Time for Reperfusion in Acute Pulmonary Embolism","OPTIRAPE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with a diagnosis of intermediate-high or high pulmonary embolism confirmed by computed tomography pulmonary angiography (CTPA), pulmonary angiography, or echocardiography (evidence of a floating thrombus in the right atrium or right ventricle, or proximal visualization of thrombus in the pulmonary artery).\n* Classified as high-risk or intermediate-high-risk according to the 2019 European Society of Cardiology guidelines.\n* Provision of informed consent for the processing of personal data.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Patients in whom a diagnosis of acute high-risk or intermediate-high-risk pulmonary embolism has been excluded.\n* Inability to provide informed consent.","ALL","18 Years",{"count":160,"type":161},500,"ESTIMATED","OBSERVATIONAL","Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality worldwide. Current guidelines recommend early reperfusion for high-risk and intermediate-high-risk PE, yet systemic thrombolysis and percutaneous therapies are frequently underutilized, and no specific timing for reperfusion is defined, unlike in acute myocardial infarction or ischemic stroke. As most PE-related in-hospital deaths occur within the first hours and thrombus composition changes over time, defining an optimal reperfusion time window may improve survival and prevent hemodynamic deterioration. We therefore propose a national, multicenter, prospective observational study to evaluate the prognostic impact of reperfusion timing, using systemic thrombolysis or catheter-directed therapies, on in-hospital mortality and haemorrhagic or cardiovascular complications.",[165,166],"Pulmonary Embolism (Diagnosis)","Pulmonary Embolism Acute",[168,169,170,171],"Fibrinolysis","Anticoagulation","Catheter-directed treatments","Time of Reperfusion","2026-03-01",{"date":174,"type":175},"2026-03-03","ACTUAL",{"date":177,"type":175},"2025-11-25",{"date":179,"type":161},"2026-10-30",{"name":5,"class":6},7]