Health Trials

About this trial

This study has to objective to assess, in adults' patients needing tracheal intubation because of vital distress, the effect of a combined strategy to reduce intubation-related morbidity. This strategy will associate systematic use of rocuronium as paralyzing agent to facilitate tracheal intubation, bag face-mask ventilation before intubation and Gum Elastic Bougie (GEB) use.

Eligibility criteria

Qualifiers

Patient adult (≥ 18 years) presenting with vital distress requiring emergency tracheal intubation as assessed by the emergency physician in the out-of-hospital setting.

Patient with all conditions (trauma, dyspnea, coma, overdoses, and shock) except those in cardiac arrest will be included.

Disqualifiers

Patient presenting of a contraindication to succinylcholine, and/or rocuronium, and/or sugammadex (rocunorium antagonist).

Patient who have contraindication to bag face mask ventilation before intubation (ongoing emesis, hematemesis, or hemoptysis).

Patient that are not members of a medical aid scheme (beneficiary or main member).

Patient under specific protection measures: pregnant, parturient or nursing women; legal protection or deprived of liberty: patient under judicial protection, patient under guardianship/curatorship.

Trial design

Treatments tested in this trial

  • Data patient
  • Physical examination
  • Rapid sequence intubation (RSI) : Rocuronium /Bag-mask ventilation /GEB
  • Rapid sequence intubation (RSI) : Recommendations for emergency intubation

Treatment groups

1,500 Participants
are divided into 2 treatment groups

Locations

22
CHU d'Angers49933, Angers France
CH Carnelle Portes de l'Oise95260, Beaumont-sur-Oise France
AP-HP - Hôpital Avicenne93000, Bobigny France
CHU de Bordeaux - Hôpital Pellegrin33000, Bordeaux France

Sponsors and collaborators

University Hospital, Bordeaux

Lead sponsor

Source ClinicalTrials.gov